Effects of pioglitazone on metabolic parameters, body fat distribution, and serum adiponectin levels in Japanese male patients with type 2 diabetes
Abstract
The aim of this study was to evaluate the effects of pioglitazone on clinical and metabolic parameters, body fat distribution, and serum adiponectin, a recently discovered antiatherosclerotic hormone, in Japanese patients with type 2 diabetes. Ten male patients aged 40 to 66 (57.7 +/- 7.4) years, who were being treated with dietary therapy alone (n = 7) or with a stable dose of sulfonylurea (n = 3), were studied at baseline and after 3 months of pioglitazone treatment (30 mg/d). Body mass index (BMI), blood pressure, fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c), serum insulin, adiponectin, and lipid profile were measured. Also, visceral adipose tissue area (VAT) and subcutaneous adipose tissue area (SAT) at the umbilical level were determined by computed tomographic (CT) scanning. Mean blood pressure (109 +/- 14 to 101 +/- 10 mm Hg), FPG (8.6 +/- 1.4 to 7.0 +/- 1.0 mmol/L), serum insulin (54 +/- 11 to 30 +/- 8 pmol/L, P <.01 for all), and HbA1c (6.7 +/- 0.8 to 6.1% +/- 0.6%, P =.013) decreased significantly during 3 months of pioglitazone treatment. BMI (26.4 +/- 3.2 to 27.0 +/- 3.5 kg/m2), low-density lipoprotein (LDL) cholesterol (124 +/- 24 to 138 +/- 24 mg/dL) and SAT (155 +/- 69 to 179 +/- 81cm2, P <.05 for all) increased, while triglycerides and high-density lipoprotein (HDL) cholesterol did not change significantly after 3 months of pioglitazone treatment. Serum adiponectin level increased in all patients (4.8 +/- 1.7 to 14.4 +/- 2.1 microg/mL, P =.005). VAT tended to increase (165 +/- 38 to 180 +/- 46 cm2) and VAT/SAT ratio tended to decrease (1.2 +/- 0.3 to 1.1 +/- 0.3), but these differences did not reach statistical significance. These results suggest that pioglitazone exerts good glycemic and blood pressure control despite increased BMI and SAT in Japanese male patients with type 2 diabetes. It is also suggested that pioglitazone may have an antiatherosclerotic effect by increasing serum adiponectin level.
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Thiazolidinediones, which induce adipocyte differentiation, improve insulin sensitivity and increase fat deposition in the subcutaneous rather than the intra-abdominal fat compartment.
“the thiazolidinediones, which induce adipocyte differentiation [63], not only improve insulin sensitivity but also increase fat deposition in the subcutaneous rather than the intra-abdominal fat compartment [64, 65].”
From The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes (2003) · cites this paper as [64]
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- Authors
- Hirose, H., Kawai, T., Yamamoto, Y., Taniyama, M., Tomita, M., Matsubara, K., Okazaki, Y., Ishii, T., Oguma, Y., Takei, I., & Saruta, T.
- Affiliations
- SHOWA Medical University (JP)
- Venue
- Metabolism
- Publisher
- Elsevier BV
- Published
- 2002-03
- Volume
- 51
- Issue
- 3
- Pages
- 314-317
- ISSN
- 0026-0495 (ISSN-L)
- OpenAlex
- W2020949125
- Cited by
- 235
- References
- 30
- Citations by year
- 2025: 2 · 2022: 2 · 2021: 8 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 5 · 2016: 5 · 2015: 4 · 2014: 9 · 2013: 7 · 2012: 6
- FWCI
- 18.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- pioglitazone, type 2 diabetes, adiponectin, body fat distribution, visceral adipose tissue, subcutaneous adipose tissue, insulin, HbA1c, lipid profile, sulfonylureas, Japanese men, thiazolidinediones, atherosclerosis risk factors, blood pressure, body mass index
- MeSH terms
- Pioglitazone, Adipose Tissue, Adult, Diabetes Mellitus, Type 2, Humans, Hypoglycemic Agents, Japan, Male, Middle Aged, Proteins, Thiazoles, Time Factors, Intercellular Signaling Peptides and Proteins, Asian People, Thiazolidinediones, Adiponectin
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