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Cited by 196Pregnancy and preeclampsia studiesBirth, Development, and HealthReproductive System and Pregnancy

Placental Oxygen Consumption. Part I: In Vivo Studies—A Review

Carter, A.M.·2000·Placenta
DOI 10.1053/plac.1999.0513
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Abstract

At term of pregnancy, oxygen consumption by the human or ovine placenta accounts for 40 per cent of total oxygen uptake by the gravid uterus. In the sheep, most oxygen is used for oxidative phosphorylation of glucose; the remainder is probably utilized for non-mitochondrial processes. The ATP yield is expended mainly in protein synthesis and cation transport. The fractional protein synthesis rate of ovine placenta is 60 per cent per day. Applying these data to man, protein synthesis is estimated to account for about 30 per cent of placental oxygen uptake. Probably this reflects the high rates of synthesis of peptide and steroid hormones. The Na+ gradient is the basis for secondary active transport of amino acids and other substances, and the Na(+)-K(+)-pump probably accounts for 20-30 per cent of oxygen uptake, with a smaller contribution from Ca(2+)-ATPase. Placental oxygen uptake remains constant during acute reductions in uterine oxygen supply and is maintained at the expense of the fetus. In the longer term, in experimental models of fetal growth restriction, placental oxygen consumption is reduced to a greater extent than fetal oxygen consumption. Placental oxygen consumption is greatly reduced under in vitro experimental conditions, due largely to an inadequate oxygen supply. This results in reduced protein synthesis and possibly inhibition of Na(+)-K(+)-ATPase. However, if the placenta is subjected to hyperoxia, by raising the PO2 of the medium, there is an increase in anaerobic glycolysis and structural damage may ensue. Premature exposure of trophoblast to high oxygen tensions in vivo may result in reduced villous branching, but this is likely to be a cause, rather than a consequence, of reduced fetal growth and oxygen consumption.

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Crossref · 10.1053/plac.1999.0513

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  • The placenta accounts for about 40% of the oxygen consumption of the fetal-placental unit, of which about 33% is utilized in active transport and about 33% in protein synthesis.

    “Thus, it has been estimated that the placenta accounts for ~40% of the oxygen consumption of the fetal-placental unit, and of that ~33% is utilized in active transport and ~33% in protein synthesis (97).”

    From Placental Origins of Chronic Disease (2016) · cites this paper as [97]

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Authors
Carter, A. M.
Affiliations
University of Southern Denmark (DK)
Corresponding author
Carter, A.M.
ORCID
Carter, A.M.
Venue
Placenta
Publisher
Elsevier BV
Published
2000-03
Volume
21
Pages
S31-S37
ISSN
0143-4004 (ISSN-L)
DOI
10.1053/plac.1999.0513
OpenAlex
W2024996129
Cited by
196
References
48
Citations by year
2026: 10 · 2025: 14 · 2024: 8 · 2023: 9 · 2022: 14 · 2021: 16 · 2020: 11 · 2019: 13 · 2018: 7 · 2017: 9 · 2016: 5 · 2015: 10 · 2014: 4 · 2013: 2 · 2012: 10
FWCI
3.83
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Placenta (publishedVersion)
  • PubMed (publishedVersion)
  • University of Southern Denmark Research Portal (University of Southern Denmark) (submittedVersion)
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
Keywords
oxidative phosphorylation, protein synthesis, Na+/K+-ATPase, Na+ gradient, cation transport, fetal growth restriction, hyperoxia, anaerobic glycolysis, trophoblast, ovine placenta, human placenta, fetal oxygenation
MeSH terms
Sodium-Potassium-Exchanging ATPase, Adenosine Triphosphate, Animals, Female, Fetus, Humans, Infant, Maternal-Fetal Exchange, Oxygen Consumption, Placenta, Pregnancy, Pregnancy Proteins, Sheep, Ion Transport, Hyperoxia

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