The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Activation and activities of the p53 tumour suppressor protein
Open accessAbstract
The p53 tumour suppressor protein inhibits malignant progression by mediating cell cycle arrest, apoptosis or repair following cellular stress. One of the major regulators of p53 function is the MDM2 protein, and multiple forms of cellular stress activate p53 by inhibiting the MDM2-mediated degradation of p53. Mutations in p53, or disruption of the pathways that allow activation of p53, seem to be a general feature of all cancers. Here we review recent advances in our understanding of the pathways that regulate p53 and the pathways that are induced by p53, as well as their implications for cancer therapy.
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Cites
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“Malignancies that retain the wild-type p53 gene have often acquired other mechanisms to compromise p53 function, and most cancer cells show a defect either in p53 or in the pathway that leads to activation of p53 in response to oncogenic stimuli (Vogelstein et al, 2000).”
BackgroundDeath Receptors: Signaling and Modulation
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Mdm2 promotes the rapid degradation of p53
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Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
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Regulation of p53 stability by Mdm2
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“However, a more comprehensive inhibition of p53 function is achieved by the ability of MDM2 to promote proteasome-mediated degradation of p53 (Haupt et al, 1997; Kubbutat et al, 1997).”
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“Since the MDM2 gene is a transcriptional target of p53 (Barak et al, 1993), an autoregulatory feedback loop exists in which p53 activates expression of its own negative regulator (Wu et al, 1993).”
BackgroundNoxa, a BH3-Only Member of the Bcl-2 Family and Candidate Mediator of p53-Induced Apoptosis
Oda, E., Ohki, R., Murasawa, H., Nemoto, J., Shibue, T., Yamashita, T., Tokino, T., Taniguchi, T., & Tanaka, †. N. (2000) · Science · doi:10.1126/science.288.5468.1053 · Cited by 2,112
DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2
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Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
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Cited by
Live or let die: the cell's response to p53
Vousden, K. H., & Lu, X. (2002) · Nature Reviews Cancer · doi:10.1038/nrc864 · Cited by 3,192
Self-citationHaupt, S., Berger, M., Goldberg, Z., & Haupt, Y. (2003) · Journal of Cell Science · doi:10.1242/jcs.00739 · Cited by 1,136
Drug discovery in the ubiquitin–proteasome system
Nalepa, G., Rolfe, M., & Harper, J. W. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2056 · Cited by 608
Xie, H., Vucetic, S., Iakoucheva, L. M., Oldfield, C. J., Dunker, A. K., Uversky, V. N., & Obradovic, Z. (2007) · Journal of Proteome Research · doi:10.1021/pr060392u · Cited by 560
Slug Antagonizes p53-Mediated Apoptosis of Hematopoietic Progenitors by Repressing puma
Wu, W.-S., Heinrichs, S., Xu, D., Garrison, S. P., Zambetti, G. P., Adams, J. M., & Look, A. T. (2005) · Cell · doi:10.1016/j.cell.2005.09.029 · Cited by 398
Metadata
- Authors
- Bálint, É., & Vousden, K. H.
- Venue
- British Journal of Cancer
- Published
- 2001-12
- Volume
- 85
- Issue
- 12
- Pages
- 1813-1823
- ISSN
- 0007-0920 (ISSN-L)
- 1532-1827
- OpenAlex
- W1990431346
- Cited by
- 313
- References
- 44
- FWCI
- 9.91
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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