GLP-1 receptor agonist use does not increase risk of respiratory complications post-endoscopy
Open accessAbstract
Data on respiratory complications associated with GLP-1 receptor agonist (GLP-1 RA) use before endoscopic procedures are limited. We conducted a retrospective cohort study using TriNetX in adults with diabetes or obesity on GLP-1 RAs within 3 months of endoscopy, comparing them with non-GLP-1 RA users. Propensity score matching and Cox proportional hazards models were used to assess outcomes. Among 46,948 patients, no significant differences in post-endoscopy aspiration pneumonitis (hazard ratio [HR] 0.92, 95% confidence interval [CI] 0.54–1.56) or pneumonia (HR 1.01, 95% CI 0.83–1.24) were found between groups. GLP-1 RA use before endoscopy does not increase respiratory complications, supporting continued preoperative medication use.
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Population-based studies have reported mixed findings on the potential association between GLP-1RA use and aspiration pneumonia.
“Population-based studies have reported mixed findings on the potential association between GLP-1RA use and aspiration pneumonia (39–44).”
From The science of safety: adverse effects of GLP-1 receptor agonists as glucose-lowering and obesity medications (2026) · cites this paper as [44]
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Glucagon-Like Peptide-1 Receptor Agonist Use and Residual Gastric Content Before Anesthesia
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“Population-based studies have reported mixed findings on the potential association between GLP-1RA use and aspiration pneumonia (39– 44).”
- Authors
- Velji-Ibrahim, J., Nathani, P., Patel, H. K., & Sharma, P.
- Affiliations
- Prisma Health (US)
- University of Kansas Medical Center (US)
- Corresponding author
- Velji-Ibrahim, Jena
- Venue
- Endoscopy International Open
- Publisher
- Georg Thieme Verlag KG
- Published
- 2024-11-25
- Volume
- 13
- Issue
- CP
- Pages
- a24872937-a24872937
- ISSN
- 2196-9736 (ISSN-L)
- 2364-3722
- PMC
- PMC11827728
- OpenAlex
- W4404732549
- Cited by
- 6
- References
- 4
- Citations by year
- 2026: 3 · 2025: 3
- FWCI
- 1.98
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Endoscopy International Open (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Airway Management and Intubation Techniques
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac, Anesthesia and Surgical Outcomes
- Keywords
- GLP-1 receptor agonists, respiratory complications, preoperative medication use, diabetes mellitus, obesity, endoscopy
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