Preoperative GLP-1 Receptor Agonist Use and Risk of Postoperative Respiratory Complications
Open accessAbstract
This cohort study evaluates the risk of postoperative respiratory complications among patients with diabetes undergoing surgery who had vs those who had not a prescription fill for glucagon-like peptide 1 receptor agonists.
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Population-based studies have reported mixed findings on the potential association between GLP-1RA use and aspiration pneumonia.
“Population-based studies have reported mixed findings on the potential association between GLP-1RA use and aspiration pneumonia (39–44).”
From The science of safety: adverse effects of GLP-1 receptor agonists as glucose-lowering and obesity medications (2026) · cites this paper as [43]
Recent studies reported no significant differences in respiratory complications between users and non-users of GLP-1 RAs.
“recent studies have reported no significant differences in respiratory complications between users and non-users of GLP-1 RAs”
From Delayed gastric emptying induced by glucagon-like peptide-1 receptor agonists and its implications for perioperative risk during anesthesia (2026) · cites this paper as [56]
Cites
Understanding Costs of Care in the Operating Room
Childers, C. P., & Maggard-Gibbons, M. A. (2018) · JAMA Surgery · doi:10.1001/jamasurg.2017.6233 · Cited by 929 · see citing works
Ramachandran, S. K., Nafiu, O. O., Ghaferi, A. A., Tremper, K. K., Shanks, A. M., & Kheterpal, S. (2011) · Anesthesiology · doi:10.1097/aln.0b013e31821cf6de · Cited by 206 · see citing works
van Zuylen, M. L., Siegelaar, S. E., Plummer, M. P., Deane, A. M., Hermanides, J., & Hulst, A. H. (2024) · British Journal of Anaesthesia · doi:10.1016/j.bja.2024.01.001 · Cited by 132 · see citing works
Tewfik, G., Rodriguez-Aponte, C., Zhang, K., Ezzat, B., Suri, P., & Chaudhry, F. (2022) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000006156 · Cited by 12 · see citing works
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Mapping the effectiveness and risks of GLP-1 receptor agonists
Xie, Y., Choi, T., & Al-Aly, Z. (2025) · Nature Medicine · doi:10.1038/s41591-024-03412-w · Cited by 300 · see citing works
Clinical Consequences of Delayed Gastric Emptying With GLP-1 Receptor Agonists and Tirzepatide
Jalleh, R. J., Plummer, M. P., Marathe, C. S., Umapathysivam, M. M., Quast, D. R., Rayner, C. K., Jones, K. L., Wu, T., Horowitz, M., & Nauck, M. A. (2024) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgae719 · Cited by 157 · see citing works
Gastrointestinal effects of GLP-1 receptor agonists: mechanisms, management, and future directions
Jalleh, R. J., Rayner, C. K., Hausken, T., Jones, K. L., Camilleri, M., & Horowitz, M. (2024) · The Lancet Gastroenterology & Hepatology · doi:10.1016/s2468-1253(24)00188-2 · Cited by 144 · see citing works
Oprea, A. D., Ostapenko, L. J., Sweitzer, B., Selzer, A., Irizarry-Alvarado, J. M., Hurtado Andrade, M. D., Mendez, C. E., Kelley, K. D., Stewart, E., Fernandez Robles, C. R., et al. (2025) · British Journal of Anaesthesia · doi:10.1016/j.bja.2025.04.001 · Cited by 104 · see citing works
Preoperative SGLT2 inhibitor use and postoperative diabetic ketoacidosis
Dixit, A. A., Bateman, B. T., Hawn, M. T., Odden, M. C., & Sun, E. C. (2025) · JAMA Surgery · doi:10.1001/jamasurg.2024.7082 · Cited by 47 · see citing works
Self-citationKamarajah, S. K., Gudiozzi, N., Findlay, J. M., Lee, M. J., Pinkney, T., & Markar, S. R. (2025) · eClinicalMedicine · doi:10.1016/j.eclinm.2025.103408 · Cited by 29 · see citing works
Jalleh, R. J., Talley, N. J., Horowitz, M., & Nauck, M. A. (2026) · Journal of Clinical Investigation · doi:10.1172/jci194740 · Cited by 40 · see citing works
Welk, B., McClure, J. A., Carter, B., Clarke, C., Dubois, L., & Clemens, K. K. (2024) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.15711 · Cited by 16 · see citing works
Kang, D., & Choi, D. (2026) · The Korean Journal of Internal Medicine · doi:10.3904/kjim.2025.277 · Cited by 1 · see citing works
“However, recent studies have reported no significant differences in respiratory complications between users and non-users of GLP-1 RAs, indicating the need for continued discussion and evidence refinement [56,57].”
- Authors
- Dixit, A. A., Bateman, B. T., Hawn, M. T., Odden, M. C., & Sun, E. C.
- Affiliations
- Stanford Medicine (US)
- Corresponding author
- Dixit, Anjali A.
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2024-05-21
- Volume
- 331
- Issue
- 19
- Pages
- 1672
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W4394997591
- Cited by
- 94
- References
- 4
- Citations by year
- 2026: 32 · 2025: 40 · 2024: 22
- FWCI
- 30.96
- Type
- journal article
- Language
- en
- Open access
- green
- pmc.ncbi.nlm.nih.gov
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (publishedVersion)
- Funders
- National Institutes of Health (UL1TR003142)
- National Institute on Drug Abuse (R61DA059168)
- National Institute of General Medical Sciences (T32GM089626)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac, Anesthesia and Surgical Outcomes
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Airway Management and Intubation Techniques
- Keywords
- GLP-1 receptor agonists, postoperative pulmonary complications, diabetes mellitus, surgical patients, prescription fills, perioperative medication use
- MeSH terms
- Glucagon-Like Peptide-1 Receptor, Glucagon-Like Peptide-1 Receptor Agonists, Diabetes Mellitus, Type 2, Female, Humans, Hypoglycemic Agents, Male, Middle Aged, Postoperative Complications, Respiratory Tract Diseases, Risk, Withholding Treatment
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