Increased Risk of Aspiration Pneumonia Associated With Endoscopic Procedures Among Patients With Glucagon-like Peptide 1 Receptor Agonist Use
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Population-based studies have reported mixed findings on the potential association between GLP-1RA use and aspiration pneumonia.
“Population-based studies have reported mixed findings on the potential association between GLP-1RA use and aspiration pneumonia (39–44).”
From The science of safety: adverse effects of GLP-1 receptor agonists as glucose-lowering and obesity medications (2026) · cites this paper as [39]
The paper’s methods describe a population-based retrospective cohort study, and its results report a higher risk of aspiration pneumonia among GLP-1RA users undergoing endoscopy. It supplies one finding for the cited group of studies, but does not establish that findings across population-based studies are mixed. (LLM, conf=0.85)
Experimental — accuracy not yet measuredGLP-1 RA use is significantly correlated with elevated aspiration pneumonia risk in patients undergoing gastrointestinal endoscopy, particularly among those receiving propofol sedation.
“A retrospective cohort study using the TriNetX dataset revealed a significant correlation between GLP-1 RAs use and elevated aspiration pneumonia risk in patients undergoing gastrointestinal endoscopy, particularly among those receiving propofol sedation [20].”
From Exploring the Side Effects of GLP-1 Receptor Agonist: To Ensure Its Optimal Positioning (2025) · cites this paper as [20]
In a propensity score-matched cohort study including patients using a broad range of GLP-1 RAs, GLP-1 RA therapy may be associated with an increased risk of aspiration pneumonia during endoscopic procedures.
“Conversely, Yeo et al. [48], in a propensity score–matched cohort study including patients using a broad range of GLP-1 RAs, reported that GLP-1 RA therapy may be associated with an increased risk of aspiration pneumonia during endoscopic procedures.”
From Delayed gastric emptying induced by glucagon-like peptide-1 receptor agonists and its implications for perioperative risk during anesthesia (2026) · cites this paper as [48]
In people using GLP-1 RAs long-term, there is less certainty about the risk of pulmonary aspiration, particularly because the effect of tachyphylaxis on gastric emptying is unclear.
“In people using GLP-1 RAs long-term,48 there is less certainty in regard to the risk of pulmonary aspiration,49 particularly because the effect of tachyphylaxis on gastric emptying is unclear.”
From Evaluation of safety of preoperative GLP-1 receptor agonists in patients undergoing elective surgery: a systematic review, meta-analysis and meta-regression (2025) · cites this paper as [48]
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Салухов, В. В., Щеголев, А. В., Kryukov, E. V., Surzhikov, P. V., Apostolidi, E. V., & Prochik, Y. E. (2026) · Meditsinskiy sovet = Medical Council · doi:10.21518/ms2026-161 · Cited by 1 · see citing works
GLP-1 receptor agonist use and aspiration pneumonia risk following endovascular thrombectomy
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Current Evidence and Practical Considerations for GLP-1 Receptor Agonists in Gynecologic Oncology
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- Authors
- Yeo, Y. H., Gaddam, S., Ng, W. H., Huang, P.-C., Mohamed, G., Samaan, J., Yi-Jin Hsieh, T., Lee, G. Y., Watson, R., Mathur, R., Ma, K. S.-K., & Rezaie, A.
- Affiliations
- Cedars-Sinai Medical Center (US)
- University of Bristol (GB)
- Harvard University (US)
- Corresponding author
- Rezaie, Ali
- ORCID
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2024-07
- Volume
- 167
- Issue
- 2
- Pages
- 402-404.e3
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W4393237412
- Cited by
- 128
- References
- 5
- Citations by year
- 2026: 38 · 2025: 57 · 2024: 33
- FWCI
- 37.62
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Brigham and Women's Hospital
- Cedars-Sinai Medical Center
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Health Professions › Speech and Hearing › Dysphagia Assessment and Management
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Airway Management and Intubation Techniques
- Keywords
- aspiration pneumonia, GLP-1 receptor agonists, endoscopy, drug safety, adverse drug reactions, gastrointestinal endoscopy
- MeSH terms
- Glucagon-Like Peptide-1 Receptor, Glucagon-Like Peptide-1 Receptor Agonists, Aged, Female, Humans, Hypoglycemic Agents, Male, Middle Aged, Pneumonia, Aspiration, Retrospective Studies, Risk Factors, Risk Assessment
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