Cited by 179Inflammasome and immune disordersLiver Disease Diagnosis and TreatmentLiver physiology and pathology

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Inflammasomes in Liver Fibrosis

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Alegre, Fernando, Pelegrin, Pablo, Feldstein, Ariel·2017·Seminars in Liver Disease

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Abstract

Cell death and inflammation are two central elements in the development of liver fibrosis. Inflammasomes are intracellular multiprotein complexes expressed in both hepatocytes and nonparenchymal cells in the liver that are key regulators of inflammation and cell fate. They respond to cellular danger signals by activating caspase 1, releasing the proinflammatory cytokines IL-1β and IL-18, as well as initiating a novel pathway of programmed cell death termed “pyroptosis.” These processes can initiate and perpetuate an abnormal wound-healing response with the principle cellular target being the activation of hepatic stellate cells. From the various inflammasomes, the NLRP3 inflammasome has been increasingly implicated in the pathogenesis of chronic inflammatory liver diseases, including nonalcoholic steatohepatitis, a disease process that is soaring and has evolved as a primary cause of liver fibrosis and need for liver transplantation. In this review, the authors highlight the growing evidence for both indirect and direct effects of inflammasomes in triggering liver fibrosis as well as potential novel targets for antifibrotic therapies.

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Authors: Alegre, F., Pelegrin, P., & Feldstein, A.
Affiliations: Universitat de València (ES)
Director, Biomedical Research Institute of Murcia (IMIB-Arrixaca), CIBERehd, Clinical University Hospital Virgen de la Arrixaca, Murcia, Spain
University of California San Diego (US)
Corresponding author: Feldstein, Ariel
ORCID: Alegre, Fernando
Feldstein, Ariel
Venue: Seminars in Liver Disease
Publisher: Georg Thieme Verlag KG
Published: 2017-05
Volume: 37
Issue: 02
Pages: 119-127
ISSN: 0272-8087 (ISSN-L)
1098-8971
DOI: 10.1055/s-0037-1601350
OpenAlex: W2619892599
Cited by: 176
References: 98
Citations by year: 2026: 4 · 2025: 12 · 2024: 19 · 2023: 21 · 2022: 31 · 2021: 26 · 2020: 35 · 2019: 18 · 2018: 6 · 2017: 4
FWCI: 1.61
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Seminars in Liver Disease (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute on Alcohol Abuse and Alcoholism (U01AA022489)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK082451)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Keywords: inflammasome, liver fibrosis, NLRP3 inflammasome, caspase-1, IL-1β, IL-18, pyroptosis, hepatic stellate cells, nonalcoholic steatohepatitis, chronic liver inflammation, antifibrotic therapy, wound healing
MeSH terms: Alarmins, Pyroptosis, NLR Family, Pyrin Domain-Containing 3 Protein, Animals, Anti-Inflammatory Agents, Humans, Liver Cirrhosis, Signal Transduction, Inflammation Mediators, Receptors, Pattern Recognition

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