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Inflammasomes in Liver Fibrosis
Open accessAbstract
Cell death and inflammation are two central elements in the development of liver fibrosis. Inflammasomes are intracellular multiprotein complexes expressed in both hepatocytes and nonparenchymal cells in the liver that are key regulators of inflammation and cell fate. They respond to cellular danger signals by activating caspase 1, releasing the proinflammatory cytokines IL-1β and IL-18, as well as initiating a novel pathway of programmed cell death termed “pyroptosis.” These processes can initiate and perpetuate an abnormal wound-healing response with the principle cellular target being the activation of hepatic stellate cells. From the various inflammasomes, the NLRP3 inflammasome has been increasingly implicated in the pathogenesis of chronic inflammatory liver diseases, including nonalcoholic steatohepatitis, a disease process that is soaring and has evolved as a primary cause of liver fibrosis and need for liver transplantation. In this review, the authors highlight the growing evidence for both indirect and direct effects of inflammasomes in triggering liver fibrosis as well as potential novel targets for antifibrotic therapies.
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“the IL-1β receptor antagonist anakinra is currently being evaluated to limit inflammation in patients with alcoholic hepatitis (126, 127)”
From Immunoregulation of Liver Fibrosis: New Opportunities for Antifibrotic Therapy (2024) · cites this paper as [126]
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“They also secrete inflammatory and fibrogenic cytokines either directly, such as interleukin (IL)-1β and IL-18,35,36 or via extracellular vesicles containing C-X-C motif chemokine ligand (CXCL)10, a ligand for C-X-C motif chemokine receptor (CXCR)3, and mitochondrial DNA, a key TLR9 ligand.37”
From Understanding the cellular interactome of non-alcoholic fatty liver disease (2022) · cites this paper as [35]
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Cites
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
Shi, J., Zhao, Y., Wang, K., Shi, X., Wang, Y., Huang, H., Zhuang, Y., Cai, T., Wang, F., & Shao, F. (2015) · Nature · doi:10.1038/nature15514 · Cited by 6,659
A role for mitochondria in nlrp3 inflammasome activation
Zhou, R., Yazdi, A. S., Menu, P., & Tschopp, J. (2011) · Nature · doi:10.1038/nature09663 · Cited by 5,602
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
Kayagaki, N., Stowe, I. B., Lee, B. L., O’Rourke, K., Anderson, K., Warming, S., Cuellar, T., Haley, B., Roose-Girma, M., Phung, Q. T., et al. (2015) · Nature · doi:10.1038/nature15541 · Cited by 3,686
Immunological and inflammatory functions of the interleukin-1 family
Dinarello, C. A. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132612 · Cited by 3,466
Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
Liu, X., Zhang, Z., Ruan, J., Pan, Y., Magupalli, V. G., Wu, H., & Lieberman, J. (2016) · Nature · doi:10.1038/nature18629 · Cited by 3,202
Cryopyrin activates the inflammasome in response to toxins and ATP
Mariathasan, S., Weiss, D. S., Newton, K., McBride, J., O'Rourke, K., Roose-Girma, M., Lee, W. P., Weinrauch, Y., Monack, D. M., & Dixit, V. M. (2006) · Nature · doi:10.1038/nature04515 · Cited by 3,080
Hornung, V., Bauernfeind, F., Halle, A., Samstad, E. O., Kono, H., Rock, K. L., Fitzgerald, K. A., & Latz, E. (2008) · Nature Immunology · doi:10.1038/ni.1631 · Cited by 3,065
Activation and regulation of the inflammasomes
Latz, E., Xiao, T. S., & Stutz, A. (2013) · Nature Reviews Immunology · doi:10.1038/nri3452 · Cited by 2,884
A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
Coll, R. C., Robertson, A. A. B., Chae, J. J., Higgins, S. C., Muñoz-Planillo, R., Inserra, M. C., Vetter, I., Dungan, L. S., Monks, B. G., Stutz, A., et al. (2015) · Nature Medicine · doi:10.1038/nm.3806 · Cited by 2,849
Pore-forming activity and structural autoinhibition of the gasdermin family
Ding, J., Wang, K., Liu, W., She, Y., Sun, Q., Shi, J., Sun, H., Wang, D.-C., & Shao, F. (2016) · Nature · doi:10.1038/nature18590 · Cited by 2,771
Non-canonical inflammasome activation targets caspase-11
Kayagaki, N., Warming, S., Lamkanfi, M., Walle, L. V., Louie, S., Dong, J., Newton, K., Qu, Y., Liu, J., Heldens, S., et al. (2011) · Nature · doi:10.1038/nature10558 · Cited by 2,530
Inflammatory caspases are innate immune receptors for intracellular LPS
Shi, J., Zhao, Y., Wang, Y., Gao, W., Ding, J., Li, P., Hu, L., & Shao, F. (2014) · Nature · doi:10.1038/nature13683 · Cited by 2,285
Muñoz-Planillo, R., Kuffa, P., Martínez-Colón, G. J., Smith, B. L., Rajendiran, T. M., & Núñez, G. (2013) · Immunity · doi:10.1016/j.immuni.2013.05.016 · Cited by 2,167
Understanding the mechanism of IL-1β secretion
Lopez-Castejon, G., & Brough, D. (2011) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2011.10.001 · Cited by 1,519
Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration
Pétrilli, V, Papin, S., Dostert, C., Mayor, A., Martinon, F., & Tschopp, J. (2007) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4402195 · Cited by 1,445
Mederacke, I., Hsu, C. C., Troeger, J. S., Huebener, P., Mu, X., Dapito, D. H., Pradere, J.-P., & Schwabe, R. F. (2013) · Nature Communications · doi:10.1038/ncomms3823 · Cited by 1,443
Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes
Lu, A., Magupalli, V. G., Ruan, J., Yin, Q., Atianand, M. K., Vos, M. R., Schröder, G. F., Fitzgerald, K. A., Wu, H., & Egelman, E. H. (2014) · Cell · doi:10.1016/j.cell.2014.02.008 · Cited by 1,353
Caspase‐1‐induced pyroptotic cell death
Miao, E. A., Rajan, J. V., & Aderem, A. A. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01044.x · Cited by 1,162
GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death
Sborgi, L., Rühl, S., Mulvihill, E., Pipercevic, J., Heilig, R., Stahlberg, H., Farady, C. J., Müller, D. J., Broz, P., & Hiller, S. (2016) · The EMBO Journal · doi:10.15252/embj.201694696 · Cited by 1,152
Charlton, M., Burns, J. M., Pedersen, R. A., Watt, K. D. S., Heimbach, J. K., & Dierkhising, R. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.06.061 · Cited by 1,115
NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice
Mridha, A. R., Wree, A., Robertson, A. A. B., Yeh, M. M., Johnson, C. D., Van Rooyen, D. M., Haczeyni, F., Teoh, N. C.-H., Savard, C., Ioannou, G. N., et al. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2017.01.022 · Cited by 1,110
Self-citationNucleotide sequence of human monocyte interleukin 1 precursor cDNA.
Auron, P. E., Webb, A. C., Rosenwasser, L. J., Mucci, S. F., Rich, A., Wolff, S. M., & Dinarello, C. A. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.24.7907 · Cited by 1,042
Fernandes-Alnemri, T., Wu, J., Yu, J.-W., Datta, P., Miller, B., Jankowski, W., Rosenberg, S., Zhang, J., & Alnemri, E. S. (2007) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4402194 · Cited by 1,026
The NLR Gene Family: A Standard Nomenclature
Ting, J. P. ‐., Lovering, R. C., Alnemri, E. S., Bertin, J., Boss, J. M., Davis, B. K., Flavell, R. A., Girardin, S. E., Godzik, A., Harton, J. A., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.02.005 · Cited by 998
Critical role for calcium mobilization in activation of the NLRP3 inflammasome
Murakami, T., Öckinger, J., Yu, J., Byles, V., McColl, A., Hofer, A. M., & Horng, T. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1117765109 · Cited by 961
Wree, A., Eguchi, A., McGeough, M. D., Pena, C. A., Johnson, C. D., Canbay, A., Hoffman, H. M., & Feldstein, A. E. (2014) · Hepatology · doi:10.1002/hep.26592 · Cited by 945
Self-citationRapid Secretion of Interleukin-1β by Microvesicle Shedding
Mackenzie, A. B., Wilson, H. L., Kiss‐Toth, E., Dower, S., North, R. A., & Surprenant, A. (2001) · Immunity · doi:10.1016/s1074-7613(01)00229-1 · Cited by 862
Active Caspase-1 Is a Regulator of Unconventional Protein Secretion
Keller, M., Rüegg, A., Werner, S., & Beer, H. (2008) · Cell · doi:10.1016/j.cell.2007.12.040 · Cited by 851
Baroja-Mazo, A., Martín-Sánchez, F., Gomez, A. I., Martínez, C. M., Amores-Iniesta, J., Compan, V., Barberà-Cremades, M., Yagüe, J., Ruiz-Ortiz, E., Antón, J., et al. (2014) · Nature Immunology · doi:10.1038/ni.2919 · Cited by 790
The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation
Franklin, B. S., Bossaller, L., De Nardo, D., Ratter, J. M., Stutz, A., Engels, G., Brenker, C., Nordhoff, M., Mirandola, S. R., Al-Amoudi, A., et al. (2014) · Nature Immunology · doi:10.1038/ni.2913 · Cited by 773
Kolb, M. R. J., Margetts, P. J., Anthony, D. C., Pitossi, F. J., & Gauldie, J. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12568 · Cited by 754
Toll-Like Receptor 9 Promotes Steatohepatitis by Induction of Interleukin-1β in Mice
Miura, K., Kodama, Y., Inokuchi, S., Schnabl, B., Aoyama, T., Ohnishi, H., Olefsky, J. M., Brenner, D. A., & Seki, E. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.03.052 · Cited by 741
IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice
Petrasek, J., Bala, S., Csak, T., Lippai, D., Kodys, K., Menashy, V., Barrieau, M., Min, S.-Y., Kurt-Jones, E. A., & Szabo, G. (2012) · Journal of Clinical Investigation · doi:10.1172/jci60777 · Cited by 735
Evolving therapies for liver fibrosis
Schuppan, D., & Kim, Y. O. (2013) · Journal of Clinical Investigation · doi:10.1172/jci66028 · Cited by 610
K + Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria
Groß, C. J., Mishra, R., Schneider, K. S., Médard, G., Wettmarshausen, J., Dittlein, D., Shi, H., Gorka, O., Koenig, P.-A., Fromm, S., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.08.010 · Cited by 550
ASC, a Novel 22-kDa Protein, Aggregates during Apoptosis of Human Promyelocytic Leukemia HL-60 Cells
Masumoto, J., Taniguchi, S., Ayukawa, K., Sarvotham, H., Kishino, T., Niikawa, N., Hidaka, E., Katsuyama, T., Higuchi, T., & Sagara, J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.48.33835 · Cited by 542
Gasse, P., Mary, C., Guénon, I., Noulin, N., Charron, S., Schnyder‐Candrian, S., Schnyder, B., Akira, S., Quesniaux, V. F. J., Lagente, V., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci32285 · Cited by 503
Inflammasomes in liver diseases
Szabó, G., & Csák, T. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.03.035 · Cited by 498
Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9
Garcia-Martinez, I., Santoro, N., Chen, Y., Hoque, R., Ouyang, X., Caprio, S., Shlomchik, M. J., Coffman, R. L., Candia, A., & Mehal, W. Z. (2016) · Journal of Clinical Investigation · doi:10.1172/jci83885 · Cited by 498
NLRP3 inflammasome activation is required for fibrosis development in NAFLD
Wree, A., McGeough, M. D., Peña, C. A., Schlattjan, M., Li, H., Inzaugarat, M. E., Messer, K., Canbay, A., Hoffman, H. M., & Feldstein, A. E. (2014) · Journal of Molecular Medicine · doi:10.1007/s00109-014-1170-1 · Cited by 486
Self-citationGroß, O., Yazdi, A. S., Thomas, C. J., Masin, M., Heinz, L. X., Guarda, G., Quadroni, M., Drexler, S. K., & Tschopp, J. (2012) · Immunity · doi:10.1016/j.immuni.2012.01.018 · Cited by 479
Negash, A. A., Ramos, H. J., Crochet, N., Lau, D., Doehle, B., Papić, N., Delker, D. A., Jo, J., Bertoletti, A., Hagedorn, C. H., et al. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003330 · Cited by 424
Cell Volume Regulation Modulates NLRP3 Inflammasome Activation
Compan, V., Baroja‐Mazo, A., López‐Castejón, G., Gomez, A. I., Martínez, C. M., Angosto-Bazarra, D., Montero, M. T., Herranz, A. S., Bazán, E., Reimers, D., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.06.013 · Cited by 407
The global burden of liver disease: a challenge for methods and for public health
Byass, P. (2014) · BMC Medicine · doi:10.1186/s12916-014-0159-5 · Cited by 331
Barreyro, F. J., Holod, S., Finocchietto, P. V., Camino, A. M., Aquino, J. B., Avagnina, A., Carreras, M. C., Poderoso, J. J., & Gores, G. J. (2014) · Liver International · doi:10.1111/liv.12570 · Cited by 302
Kamari, Y., Shaish, A., Vax, E., Shemesh, S. S., Kandel-Kfir, M., Arbel, Y., Olteanu, S., Barshack, I., Dotan, S., Voronov, E., et al. (2011) · Journal of Hepatology · doi:10.1016/j.jhep.2011.01.048 · Cited by 294
Inflammasome-dependent IL-1β release depends upon membrane permeabilisation
Martín‐Sánchez, F., Diamond, C. E., Zeitler, M., Gomez, A. I., Baroja‐Mazo, A., Bagnall, J., Spiller, D. G., White, M. H., Daniels, M. J. D., Mortellaro, A., et al. (2016) · Cell Death and Differentiation · doi:10.1038/cdd.2015.176 · Cited by 293
Miura, K., Yang, L., van Rooijen, N., Brenner, D. A., Ohnishi, H., & Seki, E. (2012) · Hepatology · doi:10.1002/hep.26081 · Cited by 290
Zhan, S.-S., Jiang, J. X., Wu, J., Halsted, C., Friedman, S. L., Zern, M. A., & Torok, N. J. (2006) · Hepatology · doi:10.1002/hep.21093 · Cited by 284
Interleukin-1 participates in the progression from liver injury to fibrosis
Gieling, R. G., Wallace, K., & Han, Y.-P. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90564.2008 · Cited by 279
K+ Efflux Agonists Induce NLRP3 Inflammasome Activation Independently of Ca2+ Signaling
Katsnelson, M. J., Rucker, L. G., Russo, H. M., & Dubyak, G. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402658 · Cited by 278
Macrophage autophagy protects against liver fibrosis in mice
Lodder, J., Denaës, T., Chobert, M.-N., Wan, J., El-Benna, J., Pawlotsky, J.-M., Lotersztajn, S., & Teixeira-Clerc, F. (2015) · Autophagy · doi:10.1080/15548627.2015.1058473 · Cited by 266
Pan-caspase inhibitor VX-166 reduces fibrosis in an animal model of nonalcoholic steatohepatitis #
Witek, R. P., Stone, C. W., Karaca, G., Syn, W., Pereira, T. A., Agboola, K. M., Omenetti, A., Jung, Y., Teaberry, V. S., Choi, S. S., et al. (2009) · Hepatology · doi:10.1002/hep.23167 · Cited by 252
Diverse Activators of the NLRP3 Inflammasome Promote IL-1β Secretion by Triggering Necrosis
Cullen, S. P., Kearney, C. J., Clancy, D. M., & Martin, S. J. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.05.003 · Cited by 234
Inflammasome-mediated regulation of hepatic stellate cells
Watanabe, A., Sohail, M. A., Gomes, D. A., Hashmi, A., Nagata, J., Sutterwala, F. S., Mahmood, S., Jhandier, M. N., Shi, Y., Flavell, R. A., et al. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90223.2008 · Cited by 233
Response to local inflammation of IL-1 beta-converting enzyme- deficient mice
Fantuzzi, G., Ku, G., Harding, M. W., Livingston, D. J., Sipe, J. D., Kuida, K., Flavell, R. A., & Dinarello, C. A. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.4.1818 · Cited by 232
Takehara, T., Tatsumi, T., Suzuki, T., Rucker, E. B., Hennighausen, L. G., Jinushi, M., Miyagi, T., Kanazawa, Y., & Hayashi, N. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.07.019 · Cited by 223
Povero, D., Panera, N., Eguchi, A., Johnson, C. D., Papouchado, B. G., de Araujo Horcel, L., Pinatel, E. M., Alisi, A., Nobili, V., & Feldstein, A. E. (2015) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2015.07.007 · Cited by 221
Self-citationPerregaux, D. G., McNiff, P. A., Laliberte, R. E., Hawryluk, N. A., Peurano, H., Stam, E. J., Eggler, J., Griffiths, R., Dombroski, M. A., & Gabel, C. A. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29317-4 · Cited by 218
Laliberte, R. E., Perregaux, D. G., Hoth, L. R., Rosner, P. J., Jordan, C. K., Peese, K. M., Eggler, J. F., Dombroski, M. A., Geoghegan, K. F., & Gabel, C. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211596200 · Cited by 211
Caspase-1 as a Central Regulator of High Fat Diet-Induced Non-Alcoholic Steatohepatitis
Dixon, L. J., Flask, C. A., Papouchado, B. G., Feldstein, A. E., & Nagy, L. E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056100 · Cited by 195
Self-citationAn NLRP3-specific inflammasome inhibitor attenuates crystal-induced kidney fibrosis in mice
Ludwig‐Portugall, I., Bartok, E., Dhana, E., Evers, B. D. G., Primiano, M. J., Hall, J. P., Franklin, B. S., Knolle, P. A., Hornung, V., Hartmann, G., et al. (2016) · Kidney International · doi:10.1016/j.kint.2016.03.035 · Cited by 195
Primiano, M. J., Lefker, B. A., Bowman, M. R., Bree, A. G., Hubeau, C., Bonin, P. D., Mangan, M., Dower, K., Monks, B. G., Cushing, L., et al. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600035 · Cited by 179
Palacios, R. S., Roderfeld, M., Hemmann, S., Räth, T., Atanasova, S., Tschuschner, A., Gressner, O. A., Weiskirchen, R., Graf, J., & Roeb, E. (2008) · Laboratory Investigation · doi:10.1038/labinvest.2008.91 · Cited by 175
Thapaliya, S., Wree, A., Povero, D., Inzaugarat, M. E., Berk, M., Dixon, L., Papouchado, B. G., & Feldstein, A. E. (2014) · Digestive Diseases and Sciences · doi:10.1007/s10620-014-3167-6 · Cited by 162
Self-citationCaspase-1-mediated regulation of fibrogenesis in diet-induced steatohepatitis
Dixon, L. J., Berk, M. P., Thapaliya, S., Papouchado, B. G., & Feldstein, A. E. (2012) · Laboratory Investigation · doi:10.1038/labinvest.2012.45 · Cited by 159
Self-citationAnstee, Q. M., Concas, D., Kudo, H., Levene, A., Pollard, J. R., Charlton, P., Thomas, H. C., Thursz, M. R., & Goldin, R. D. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2010.03.016 · Cited by 157
Ganz, M., Bukong, T. N., Csák, T., Saha, B., Park, J., Ambade, A., Kodys, K., & Szabó, G. (2015) · Journal of Translational Medicine · doi:10.1186/s12967-015-0552-7 · Cited by 149
Yang, D., Postnikov, Y. V., Li, Y., Tewary, P., de la Rosa, G., Wei, F., Klinman, D. M., Gioannini, T. L., Weiss, J. P., Furusawa, T., et al. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20101354 · Cited by 149
Boaru, S. G., Borkham‐Kamphorst, E., Tihaa, L., Haas, U., & Weiskirchen, R. (2012) · Journal of Inflammation · doi:10.1186/1476-9255-9-49 · Cited by 142
Sagoo, P., Garcia, Z., Bréart, B., Lemaı̂tre, F., Michonneau, D., Albert, M. L., Lévy, Y., & Bousso, P. (2015) · Nature Medicine · doi:10.1038/nm.4016 · Cited by 141
de Torre‐Minguela, C., Barberà-Cremades, M., Gómez, A. I., Martín‐Sánchez, F., & Pelegrı́n, P. (2016) · Scientific Reports · doi:10.1038/srep22586 · Cited by 135
Iracheta‐Vellve, A., Petrášek, J., Satishchandran, A., Gyöngyösi, B., Saha, B., Kodys, K., Fitzgerald, K. A., Kurt‐Jones, E. A., & Szabó, G. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.06.013 · Cited by 134
The types of hepatic myofibroblasts contributing to liver fibrosis of different etiologies
Xu, J., Liu, X., Koyama, Y., Wang, P., Lan, T., Kim, I., Kim, I. H., Ma, H., & Kisseleva, T. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00167 · Cited by 130
Tzeng, T.-C. J., Schattgen, S., Monks, B. G., Wang, D., Cerny, A., Latz, E., Fitzgerald, K. A., & Golenbock, D. T. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.06.011 · Cited by 125
Cai, S., Yang, R., Li, Y., Ning, Z., Zhang, L., Zhou, G.-S., Luo, W., Li, D.-H., Chen, Y., Pan, M., et al. (2016) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6498 · Cited by 104
Wree, A., Schlattjan, M., Bechmann, L. P., Claudel, T., Sowa, J., Stojaković, T., Scharnagl, H., Köfeler, H. C., Baba, H. A., Gerken, G., et al. (2014) · Metabolism · doi:10.1016/j.metabol.2014.09.001 · Cited by 103
Self-citationSphingosine regulates the NLRP3‐inflammasome and IL‐1β release from macrophages
Luheshi, N., Giles, J. A., López‐Castejón, G., & Brough, D. (2011) · European Journal of Immunology · doi:10.1002/eji.201142079 · Cited by 91
Isoda, K., Sawada, S., Ayaori, M., Matsuki, T., Horai, R., Kagata, Y., Miyazaki, K., Kusuhara, M., Okazaki, M., Matsubara, O., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m412220200 · Cited by 89
GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death
Sborgi, L., Rühl, S., Mulvihill, E., Pipercevic, J., Heilig, R., Stahlberg, H., Farady, C. J., Müller, D. J., Brož, P., & Hiller, S. (2016) · edoc (University of Basel) · doi:10.5451/unibas-ep43749 · Cited by 82
Current status of inflammasome blockers as anti-inflammatory drugs
López‐Castejón, G., & Pelegrı́n, P. (2012) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2012.690032 · Cited by 77
P2X7 blockade attenuates mouse liver fibrosis
Huang, C., Yu, W., Cui, H., WANG, Y., Zhang, L., Han, F., & Huang, T. (2013) · Molecular Medicine Reports · doi:10.3892/mmr.2013.1807 · Cited by 68
Protective effect of recombinant human IL-1Ra on CCl 4 -induced acute liver injury in mice
Zhu, R. (2010) · World Journal of Gastroenterology · doi:10.3748/wjg.v16.i22.2771 · Cited by 64
An interleukin-1 receptor antagonist decreases fibrosis induced by dimethylnitrosamine in rat liver
Mancini, R., Benedetti, A., & Jézéquel, A. M. (1994) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/bf00197389 · Cited by 58
Contribution of hepatic stellate cells and matrix metalloproteinase 9 in acute liver failure
Yan, C., Zhou, L., & Han, Y. (2008) · Liver International · doi:10.1111/j.1478-3231.2008.01775.x · Cited by 54
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Wree, A., Mehal, W. Z., & Feldstein, A. E. (2016) · Seminars in Liver Disease · doi:10.1055/s-0035-1571272 · Cited by 52
Self-citationInflammasome activation in the liver: Focus on alcoholic and non-alcoholic steatohepatitis
Szabó, G., & Iracheta‐Vellve, A. (2015) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2015.06.012 · Cited by 46
Reiter, F. P., Wimmer, R., Wottke, L., Artmann, R., Nagel, J. M., Carranza, M. O., Mayr, D. C., Rust, C., Fickert, P., Trauner, M. A., et al. (2016) · World Journal of Hepatology · doi:10.4254/wjh.v8.i8.401 · Cited by 40
Yaping, Z., Wang, Y., Luqin, D., Tang, N., Ai, X., & Xixian, Y. (2013) · Apmis · doi:10.1111/apm.12155 · Cited by 34
TANG, N., Zhang, Y., Wang, Y., & Yao, X. (2013) · Molecular Medicine Reports · doi:10.3892/mmr.2013.1719 · Cited by 32
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Zhu, Z., Run-Zhi, Xiang, ■., Di, Xie, Chao, Li, Jingjing, J., Hu, Jianjun, et al. (2010) · Acta Scientiarum Naturalium Universitatis Sunyatseni · Cited by 6
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Adams, L. A., Wree, A., Melton, P. E., Jeffrey, G. P., Ching, H., de Boer, B., Olynyk, J. K., Ayonrinde, O. T., Mori, T. A., Beilin, L. J., et al. (2015) · eSpace (Curtin University) · Cited by 3
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Self-citation
Research works printed but not linked: 3
- Povero D, Panera N, Eguchi A, et al. Lipid-induced hepatocyte- derived extracellular vesicles regulate hepatic stellate cell via microRNAs targeting PPAR-γ. Cell Mol Gastroenterol Hepatol 2015;1(6):646-663.e4
- Pelegrin PInflammasome activation by danger signals In: Couillin I, Petrilli V, Martinon F, eds. The Inflammasomes. Basel, Switzerland: Springer Basel; 2011:101-121
- MacKenzie A, Wilson HL, Kiss-Toth E, Dower SK, North RA, Surprenant A. Rapid secretion of interleukin-1beta by micro- vesicle shedding. Immunity 2001;15(5):825-835
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Schuster, S., Cabrera, D., Arrese, M., & Feldstein, A. E. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0009-6 · Cited by 943
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Schwabe, R. F., & Luedde, T. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0065-y · Cited by 582
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Rahmati, M., Silva, E. A., Reseland, J. E., Heyward, C. A., & Haugen, H. J. (2020) · Chemical Society Reviews · doi:10.1039/d0cs00103a · Cited by 409
Metadata
- Authors
- Alegre, F., Pelegrin, P., & Feldstein, A.
- Affiliations
- Universitat de València (ES)
- Director, Biomedical Research Institute of Murcia (IMIB-Arrixaca), CIBERehd, Clinical University Hospital Virgen de la Arrixaca, Murcia, Spain
- University of California San Diego (US)
- Corresponding author
- Feldstein, Ariel
- Venue
- Seminars in Liver Disease
- Publisher
- Georg Thieme Verlag KG
- Published
- 2017-05
- Volume
- 37
- Issue
- 02
- Pages
- 119-127
- ISSN
- 0272-8087 (ISSN-L)
- 1098-8971
- OpenAlex
- W2619892599
- Cited by
- 176
- References
- 98
- Citations by year
- 2026: 4 · 2025: 12 · 2024: 19 · 2023: 21 · 2022: 31 · 2021: 26 · 2020: 35 · 2019: 18 · 2018: 6 · 2017: 4
- FWCI
- 1.61
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Seminars in Liver Disease (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute on Alcohol Abuse and Alcoholism (U01AA022489)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK082451)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Keywords
- inflammasome, liver fibrosis, NLRP3 inflammasome, caspase-1, IL-1β, IL-18, pyroptosis, hepatic stellate cells, nonalcoholic steatohepatitis, chronic liver inflammation, antifibrotic therapy, wound healing
- MeSH terms
- Alarmins, Pyroptosis, NLR Family, Pyrin Domain-Containing 3 Protein, Animals, Anti-Inflammatory Agents, Humans, Liver Cirrhosis, Signal Transduction, Inflammation Mediators, Receptors, Pattern Recognition
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