The DOI matches its Crossref record; 93 of the 93 references it cites were found in a registry or an index.
Colorectal Cancer in Inflammatory Bowel Disease
Open accessAbstract
Patients with inflammatory bowel disease (IBD) are at significantly increased risk of colorectal cancer (CRC), principally resulting from the pro-neoplastic effects of chronic intestinal inflammation. Epidemiologic studies continue to highlight the increased risk of CRC in IBD. However, the incidence has declined over the past 30 years, attributed to both successful CRC-surveillance programs and improved control of mucosal inflammation. Risk factors that further increase the risk of IBD-related CRC include disease duration, extent and severity, the presence of inflammatory pseudopolyps, coexistent primary sclerosing cholangitis, and a family history of CRC. All major professional societies agree that IBD-CRC surveillance should occur more frequently than in the general population. Yet, guidelines and consensus statements differ on the surveillance schedule and preferred method of surveillance. Improved sensitivity to previously "invisible" flat dysplastic lesions using high definition and chromoendoscopy methods has resulted in many guidelines abandoning requirements for random untargeted biopsies of the colon. While colonic dysplasia remains a worrisome finding, and several clinical scenarios remain best addressed by total proctocolectomy due to concerns of synchronous undetected lesions and the unpredictable tempo of progression to malignancy, better detection techniques have also increased opportunities for endoscopic resection of dysplastic lesions that can be clearly delineated. Finally, the expanding armamentarium of medical options in IBD, including anti-tumor necrosis factor and anti-adhesion biologic therapies, have substantially improved our ability to control severe inflammation and likely reduce the risk of CRC over time.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Indeed, comorbid psychological difficulties are associated with disease activity, flares, treatment response, and the necessity of surgical intervention [2,6,8,9,10,11,12,13,14,15].”
From Brief and Telehealth Acceptance and Commitment Therapy (ACT) Interventions for Stress in Inflammatory Bowel Disease (IBD): A Series of Single Case Experimental Design (SCED) Studies (2022) · cites this paper as [2]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Molodecky, N. A., Soon, I. S., Rabi, D. M., Ghali, W. A., Ferris, M., Chernoff, G., Benchimol, E. I., Panaccione, R., Ghosh, S., Barkema, H. W., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2011.10.001 · Cited by 4,833
Unravelling the pathogenesis of inflammatory bowel disease
Xavier, R. J., & Podolsky, D. K. (2007) · Nature · doi:10.1038/nature06005 · Cited by 4,364
The risk of colorectal cancer in ulcerative colitis: a meta-analysis
Eaden, J., Abrams, K. R., & Mayberry, J. F. (2001) · Gut · doi:10.1136/gut.48.4.526 · Cited by 2,948
IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer
Greten, F. R., Eckmann, L., Greten, T. F., Park, J. M., Li, Z.-W., Egan, L. J., Kagnoff, M. F., & Karin, M. (2004) · Cell · doi:10.1016/j.cell.2004.07.013 · Cited by 2,433
Effector Memory T Cells, Early Metastasis, and Survival in Colorectal Cancer
Pagès, F., Berger, A., Camus, M., Sanchez-Cabo, F., Costes, A., Molidor, R., Mlecnik, B., Kirilovsky, A., Nilsson, M., Damotte, D., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa051424 · Cited by 2,135 · cited 1×
“33 However, when exposed to a proin fl ammatory cytokines, Treg inhibition of in fl ammation and proapoptotic effects are reduced.”
Kornbluth, A. A., & Sachar, D. B. (2010) · The American Journal of Gastroenterology · doi:10.1038/ajg.2009.727 · Cited by 2,032
Cairns, S. R., Scholefield, J. H., Steele, R. J., Dunlop, M. G., Thomas, H. J. W., Evans, D. G., Eaden, J., Rutter, M. D., Atkin, W. S., Saunders, B. P., et al. (2010) · Gut · doi:10.1136/gut.2009.179804 · Cited by 1,139
Intestinal Inflammation and Cancer
Ullman, T. A., & Itzkowitz, S. H. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.01.057 · Cited by 1,127
Colorectal-Cancer Incidence and Mortality with Screening Flexible Sigmoidoscopy
Schoen, R. E., Pinsky, P. F., Weissfeld, J. L., Yokochi, L. A., Church, T. R., Laiyemo, A. O., Bresalier, R. S., Andriole, G. L., Buys, S. S., Crawford, E. D., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1114635 · Cited by 1,014
Jess, T., Rungoe, C., & Peyrin–Biroulet, L. (2012) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2012.01.010 · Cited by 958
Research works printed but not linked: 1
- Itzkowitz SH, Present DH; Crohn's and Colitis Foundation of America Colon Cancer in IBD Study Group. Inflamm Bowel Dis 2005;11(03):314-321
Cited by
Sorted by citations
Roda, G., Ng, S. C., Kotze, P. G., ARGOLLO, M. C., Panaccione, R., Spinelli, A., Kaser, A., Peyrin‐Biroulet, L., & Danese, S. (2020) · Nature Reviews Disease Primers · doi:10.1038/s41572-020-0156-2 · Cited by 1,111
Farvid, M. S., Sidahmed, E., Spence, N. D., Angua, K. M., ROSNER, B. A., & Barnett, J. B. (2021) · European Journal of Epidemiology · doi:10.1007/s10654-021-00741-9 · Cited by 473
Early-onset colorectal cancer: initial clues and current views
Hofseth, L. J., Hébert, J. R., Chanda, A., Chen, H., Love, B. L., Peña, M. M. O., Murphy, E. A., Sajish, M., Sheth, A., Buckhaults, P., et al. (2020) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0253-4 · Cited by 448
Gut bacteria signaling to mitochondria in intestinal inflammation and cancer
Jackson, D. N., & Theiss, A. L. (2020) · Gut Microbes · doi:10.1080/19490976.2019.1592421 · Cited by 312
Risk Factors for Colorectal Polyps and Cancer
Sninsky, J. A., Shore, B. M., Lupu, G. V., & Crockett, S. D. (2022) · Gastrointestinal Endoscopy Clinics of North America · doi:10.1016/j.giec.2021.12.008 · Cited by 207
Metadata
- Authors
- Higgins, P., & Stidham, R.
- Affiliations
- University of Michigan (US)
- Venue
- Clinics in Colon and Rectal Surgery
- Publisher
- Georg Thieme Verlag KG
- Published
- 2018-04-01
- Volume
- 31
- Issue
- 03
- Pages
- 168-178
- ISSN
- 1521-5741 (ISSN-L)
- 1531-0043
- 1530-9681
- PMC
- PMC5929884
- OpenAlex
- W2795176771
- Cited by
- 295
- References
- 93
- Citations by year
- 2026: 16 · 2025: 38 · 2024: 37 · 2023: 46 · 2022: 60 · 2021: 42 · 2020: 31 · 2019: 22 · 2018: 2
- FWCI
- 3.52
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Clinics in Colon and Rectal Surgery (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (K23DK101687)
- Topics
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Health Sciences › Medicine › Oncology › Colorectal Cancer Screening and Detection
- Health Sciences › Medicine › Gastroenterology › Microscopic Colitis
- Keywords
- inflammatory bowel disease, colorectal cancer, IBD-associated colorectal cancer, chronic intestinal inflammation, colorectal cancer surveillance, inflammatory pseudopolyps, primary sclerosing cholangitis, colonic dysplasia, chromoendoscopy, high-definition endoscopy, endoscopic resection, total proctocolectomy, anti-TNF therapy, disease duration
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
