The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Platelet Activation and Blood Coagulation
Abstract
Summary: Platelet activation and blood coagulation are complementary, mutually dependent processes in haemostasis and thrombosis. Platelets interact with several coagulation factors, while the coagulation product thrombin is a potent platelet-activating agonist. Activated platelets come in a procoagulant state after a prolonged elevation in cytosolic [Ca2+]i. Such platelets, e. g. when adhering to collagen via glycoprotein VI, expose phosphatidylserine (PS) at their outer surface and produce (PS-exposing) membrane blebs and microvesicles. Inhibition of aminophospholipid translocase and activation of phospholipid scramblase mediate the exposure of PS, whereas calpain-mediated protein cleavage leads to membrane blebbing and vesiculation. Surface-exposed PS strongly propagates the coagulation process by facilitating the assembly and activation of tenase and prothrombinase complexes. Factor IXa and platelet-bound factor Va support these activities. In addition, platelets can support the initiation phase of coagulation by providing binding sites for prothrombin and factor XI. They thereby take over the initiating role of tissue factor and factor VIIa in coagulation activation.
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Citations
Cites
2 retracted
Baglia, F. A., Badellino, K. O., Li, C. Q., López, J. A., & Walsh, P. N. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m108319200 · Cited by 109
RetractedDefective binding of factor XI–N248 to activated human platelets
Sun, M.-F., Baglia, F. A., Ho, D. H., Martincic, D., Ware, R. E., Walsh, P. N., & Gailani, D. (2001) · Blood · doi:10.1182/blood.v98.1.125 · Cited by 30
RetractedSeigneuret, M., & Devaux, P. F. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.12.3751 · Cited by 699
Sims, P. J., Wiedmer, T., Esmon, C. T., Weiss, H. J., & Shattil, S. J. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)71457-9 · Cited by 596
The role of phospholipid and factor VIIIa in the activation of bovine factor X.
DIEIJEN, G. V., Tans, G., Rosing, J., & Hemker, H. C. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)69627-4 · Cited by 584
Defective platelet activation in Gαq-deficient mice
Offermanns, S., Toombs, C. F., Hu, Y.-H., & Simon, M. I. (1997) · Nature · doi:10.1038/38284 · Cited by 561
Changes in membrane phospholipid distribution during platelet activation
Bevers, E. M., Comfurius, P., & Zwaal, R. F. A. (1983) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(83)90169-4 · Cited by 558
Self-citationGlycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen
Nieswandt, B. (2001) · The EMBO Journal · doi:10.1093/emboj/20.9.2120 · Cited by 548
A Subfamily of P-Type ATPases with Aminophospholipid Transporting Activity
Tang, X., Halleck, M. S., Schlegel, R. A., & Williamson, P. (1996) · Science · doi:10.1126/science.272.5267.1495 · Cited by 472
Lipid translocation across the plasma membrane of mammalian cells
Bevers, E. M., Comfurius, P., Dekkers, D. W. C., & Zwaal, R. F. A. (1999) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(99)00110-9 · Cited by 445
Self-citation
Cited by
Franz, S., Rammelt, S., Scharnweber, D., & Simon, J. C. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.05.078 · Cited by 1,391
An Apoptotic ‘Eat Me’ Signal: Phosphatidylserine Exposure
Segawa, K., & Nagata, S. (2015) · Trends in Cell Biology · doi:10.1016/j.tcb.2015.08.003 · Cited by 783
Activation of Platelet Function Through G Protein–Coupled Receptors
Offermanns, S. (2006) · Circulation Research · doi:10.1161/01.res.0000251742.71301.16 · Cited by 725
Cellular Mechanisms Underlying the Formation of Circulating Microparticles
Morel, O., Jesel, L., Freyssinet, J.-M., & Toti, F. (2011) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.109.200956 · Cited by 526
Jennings, L. (2009) · Thrombosis and Haemostasis · doi:10.1160/th09-03-0192 · Cited by 436
Metadata
- Authors
- Bevers, E., Lindhout, T., & Heemskerk, J.
- Venue
- Thrombosis and Haemostasis
- Publisher
- Georg Thieme Verlag KG
- Published
- 2002
- Volume
- 88
- Issue
- 08
- Pages
- 186-193
- ISSN
- 0340-6245 (ISSN-L)
- 2567-689X
- OpenAlex
- W2162292125
- Cited by
- 584
- References
- 53
- FWCI
- 10.11
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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