Lupus Anticoagulants and Thrombosis: Clinical Association of Different Coagulation and Immunologic Tests
Abstract
The dilute Russell's viper venom time (dRVVT) and the kaolin clotting time (KCT) are two among the most commonly used coagulation tests for the detection of lupus anticoagulants. The dRVVT seems superior to the KCT in identifying LA-positive patients at risk of thrombosis. However, this relationship is greatly influenced by both the source of reagents and the instrumentation employed to carry out the assays. Therefore, 4 dRVVTs ("home-made" dRVVT, DVV test, Bioclot LA, LA Screen), and one KCT (Kaoclot) were performed in two centers and compared for their retrospective correlation with the thrombotic complications of 72 patients with a previously established diagnosis of lupus anticoagulants. Two other assays ("home-made" KCT, and Colloidal Silica Clotting Time, CSCT) were performed in one of the two centers, and compared with Kaoclot for their clinical correlations in the same population of patients, 44 of whom (61%) had suffered from arterial and/or venous thrombosis. A rather good degree of inter-laboratory and inter-assay correlations of the different tests was found. However, a statistically significant association with thrombosis was found only with the coagulation profile generated using the "home-made" dRVVT. When the commercially available dRVVTs were used, none of the coagulation profiles remained associated with thrombosis. When the assays were analyzed separately, the association with thrombosis was statistically significant for LA screen (p = 0.0019), DVV test (p…
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
There is some evidence that the association between LA detection and clinical events is stronger for dRVVT than aPTT.
“There is some evidence that the association between LA detection and clinical events is stronger for dRVVT than aPTT [45].”
From Lupus Anticoagulant Detection under the Magnifying Glass (2023) · cites this paper as [45]
Cited by
Sorted by citations
Galli, M., Luciani, D., Bertolini, G., & Barbui, T. (2003) · Blood · doi:10.1182/blood-2002-11-3334 · Cited by 413 · see citing works
Self-citationDiagnostic Challenges on the Laboratory Detection of Lupus Anticoagulant
Tripodi, A. (2021) · Biomedicines · doi:10.3390/biomedicines9070844 · Cited by 14 · see citing works
Lupus Anticoagulant Detection under the Magnifying Glass
Molinari, A. C., Martini, T., Banov, L., Ierardi, A., Leotta, M., Strangio, A., & Santoro, R. C. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12206654 · Cited by 9 · see citing works
“There is some evidence that the association between LA detection and clinical events is stronger for dRVVT than aPTT [45].”
BackgroundViewpoint: Lupus anticoagulant detection and interpretation in antiphospholipid syndrome
Efthymiou, M., Bertolaccini, M. L., & Cohen, H. (2024) · Rheumatology · doi:10.1093/rheumatology/kead623 · Cited by 5 · see citing works
- Authors
- Dlott, J., Norbis, F., Ruggeri, L., Cler, L., Triplett, D., Barbui, T., & Galli, M.
- Affiliations
- Ball Memorial Hospital (US)
- Venue
- Thrombosis and Haemostasis
- Publisher
- Georg Thieme Verlag KG
- Published
- 2000
- Volume
- 84
- Issue
- 12
- Pages
- 1012-1016
- ISSN
- 0340-6245 (ISSN-L)
- 2567-689X
- OpenAlex
- W46715830
- Cited by
- 48
- References
- 0
- Citations by year
- 2024: 1 · 2023: 2 · 2022: 1 · 2021: 1 · 2014: 1 · 2013: 2
- FWCI
- 4.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Thrombosis and Haemostasis (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fondazione “Paolo Belli per la lotta alla leucemia”
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Health Sciences › Medicine › Surgery › Heparin-Induced Thrombocytopenia and Thrombosis
- Keywords
- lupus anticoagulant, thrombosis, dilute Russell's viper venom time, kaolin clotting time, venous thrombosis, arterial thrombosis, coagulation tests, interlaboratory comparison, assay comparison, antiphospholipid syndrome, thrombosis risk prediction
- MeSH terms
- Adult, Aged, Autoantibodies, Blood Coagulation Tests, Cardiolipins, Female, Glycoproteins, Humans, Immunologic Tests, Male, Middle Aged, Partial Thromboplastin Time, Prothrombin, Prothrombin Time, Reagent Kits, Diagnostic, Retrospective Studies, Thrombosis, Lupus Coagulation Inhibitor, beta 2-Glycoprotein I
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
