Anti–β2-glycoprotein I, antiprothrombin antibodies, and the risk of thrombosis in the antiphospholipid syndrome
Abstract
The association of antiphospholipid antibodies with thrombosis and obstetric events defines the antiphospholipid syndrome. A recent systematic review of the literature showed lupus anticoagulants to be risk factors of thrombosis, independent of the type and site of the event, the presence of
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Meta-analyses indicate that aCL and ab2GPI alone are weakly associated with thromboembolic events.
“This contention is supported by meta-analyses showing that the presence of aCL and ab2GPI alone are poorly associated with thromboembolic events [6,7].”
From Clinical course of high‐risk patients diagnosed with antiphospholipid syndrome (2010) · cites this paper as [7]
aCL are generally regarded as less symptomatic than LA or aB2GPI.
“which implies that aCL are generally regarded as less symptomatic than their conventional aPL counterparts.”
From Single or triple positivity for antiphospholipid antibodies in “carriers” or symptomatic patients: Untangling the knot (2021) · cites this paper as [8]
In the literature, among aPL, isolated LA and aB2GPI are generally found to be associated with higher thrombotic risk than aCL.
“In the literature, 5- 8 among the aPL, isolated LA and aB2GPI are generally found to be associated with higher thrombotic risk than aCL.”
From Single or triple positivity for antiphospholipid antibodies in “carriers” or symptomatic patients: Untangling the knot (2021) · cites this paper as [8]
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Self-citation
- Authors
- Galli, M., Luciani, D., Bertolini, G., & Barbui, T.
- Affiliations
- From the Division of Hematology, Ospedali Riuniti, Bergamo, Italy; and the Laboratory of Clinical Epidemiology, Istituto “Mario Negri,” Ranica Bergamo (BG), Italy.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2003-10-15
- Volume
- 102
- Issue
- 8
- Pages
- 2717-2723
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2069794594
- Cited by
- 413
- References
- 72
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 8 · 2023: 9 · 2022: 3 · 2021: 4 · 2020: 5 · 2019: 6 · 2018: 11 · 2017: 13 · 2016: 16 · 2015: 20 · 2014: 17 · 2013: 27 · 2012: 26
- FWCI
- 4.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Vasculitis and related conditions
- Keywords
- antiphospholipid syndrome, anti-beta2-glycoprotein I antibodies, anti-prothrombin antibodies, lupus anticoagulant, thrombosis risk, thrombosis risk factors, pregnancy complications
- MeSH terms
- Antibodies, Cardiolipins, Female, Glycoproteins, Humans, Pregnancy, Pregnancy Complications, Hematologic, Prothrombin, Retrospective Studies, Thrombosis, Odds Ratio, Antiphospholipid Syndrome, beta 2-Glycoprotein I
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