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Nucleus Accumbens Deep Brain Stimulation for Alcohol Addiction – Safety and Clinical Long-term Results of a Pilot Trial
Open accessAbstract
We report on the long-term clinical outcome (up to 8 years) of 5 patients who received deep brain stimulation (DBS) of the nucleus accumbens to treat their long-lasting and treatment-resistant alcohol addiction. All patients reported a complete absence of craving for alcohol; 2 patients remained abstinent for many years and 3 patients showed a marked reduction of alcohol consumption. No severe or long-standing side effects occurred. Therefore, DBS could be a promising, novel treatment option for severe alcohol addiction, but larger clinical trials are needed to further investigate the efficacy of DBS in addiction.
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“In a study of five participants with treatment-resistant alcohol use disorder who received DBS of the NAc, all reported a complete absence of craving for alcohol up to 8 years following DBS implantation; two patients remained abstinent for several years, and three showed a marked reduction of alcohol consumption [90].”
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Metadata
- Authors
- Müller, U., Sturm, V., Voges, J., Heinze, H.-J., Galazky, I., Büntjen, L., Heldmann, M., Frodl, T., Steiner, J., & Bogerts, B.
- Affiliations
- Otto-von-Guericke-Universität Magdeburg (DE)
- University of Cologne (DE)
- Department of Stereotactic Neurosurgery, Otto-von-Guericke-University of Magdeburg, Magdeburg
- Corresponding author
- Müller, U.
- Venue
- Pharmacopsychiatry
- Publisher
- Georg Thieme Verlag KG
- Published
- 2016-05-04
- Volume
- 49
- Issue
- 04
- Pages
- 170-173
- ISSN
- 0176-3679 (ISSN-L)
- 1439-0795
- OpenAlex
- W2346795379
- Cited by
- 108
- References
- 26
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 12 · 2023: 10 · 2022: 14 · 2021: 10 · 2020: 13 · 2019: 7 · 2018: 20 · 2017: 4 · 2016: 2
- FWCI
- 8.26
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Pharmacopsychiatry (publishedVersion)
- PubMed (publishedVersion)
- Kölner Universitäts PublikationsServer (Universität zu Köln) (publishedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- deep brain stimulation, nucleus accumbens, alcoholism, alcohol craving, alcohol abstinence, long-term outcomes
- MeSH terms
- Adult, Alcoholism, Humans, Longitudinal Studies, Middle Aged, Nucleus Accumbens, Pilot Projects, Psychiatric Status Rating Scales, Surveys and Questionnaires, Deep Brain Stimulation
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