Deep brain stimulation of the nucleus accumbens and its usefulness in severe opioid addiction

Deep brain stimulation of the nucleus accumbens for treatment-refractory obsessive-compulsive disorder

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Long-term effects of nucleus accumbens deep brain stimulation in treatment-resistant depression: Evidence for sustained efficacy

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Remission of alcohol dependency following deep brain stimulation of the nucleus accumbens: valuable therapeutic implications?

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Deep brain stimulation in addiction: a review of potential brain targets

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Successful deep brain stimulation of the nucleus accumbens in severe alcohol dependence is associated with changed performance monitoring

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Deep brain stimulation of nucleus accumbens on heroin-seeking behaviors: a case report

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Deep brain stimulation compared with methadone maintenance for the treatment of heroin dependence: a threshold and cost‐effectiveness analysis

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Reward Circuitry in Addiction

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The Mesolimbic Dopamine System in Chronic Pain and Associated Affective Comorbidities

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Brain Stimulation in Addiction

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A systematic review and meta-analysis of neuromodulation therapies for substance use disorders

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The neurobiology of drug addiction: cross-species insights into the dysfunction and recovery of the prefrontal cortex

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A review of brain stimulation methods to treat substance use disorders

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Brain-computer interface-based control of closed-loop brain stimulation: attitudes and ethical considerations

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Deep brain stimulation (DBS) at the interface of neurology and psychiatry

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Efficacy of invasive and non-invasive brain modulation interventions for addiction

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Transcranial magnetic stimulation, deep brain stimulation, and other forms of neuromodulation for substance use disorders: Review of modalities and implications for treatment

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Toward biomarkers of the addicted human brain: Using neuroimaging to predict relapse and sustained abstinence in substance use disorder

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The Nucleus Accumbens: A Common Target in the Comorbidity of Depression and Addiction

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The application of deep brain stimulation in the treatment of psychiatric disorders

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Nucleus Accumbens deep brain stimulation for alcohol addiction – safety and clinical long-term results of a pilot trial

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Deep brain stimulation for the treatment of drug addiction

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Long-term results after deep brain stimulation of nucleus accumbens and the anterior limb of the internal capsule for preventing heroin relapse: An open-label pilot study

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Neuromodulation interventions for addictive disorders: challenges, promise, and roadmap for future research

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A Review of Cognitive Outcomes Across Movement Disorder Patients Undergoing Deep Brain Stimulation

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Drug addiction: from bench to bedside

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Deep Brain Stimulation for Refractory Cocaine Dependence

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Treatment for Substance Use Disorder with Co-Occurring Mental Illness

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Current perspectives on deep brain stimulation for severe neurological and psychiatric disorders

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Opioid-induced structural and functional plasticity of medium-spiny neurons in the nucleus accumbens

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Deep brain stimulation improves behavior and modulates neural circuits in a rodent model of schizophrenia

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High-Frequency Stimulation of the Subthalamic Nucleus Blocks Compulsive-Like Re-Escalation of Heroin Taking in Rats

Wade, C. L., Kallupi, M., Hernandez, D. O., Breysse, E., de Guglielmo, G., Crawford, E. F., Koob, G. F., Schweitzer, P., Baunez, C., & George, O. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.270 · Cited by 56 · see citing works

Toward sophisticated basal ganglia neuromodulation: Review on basal ganglia deep brain stimulation

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Neuroimaging reward, craving, learning, and cognitive control in substance use disorders: review and implications for treatment

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Bidirectional Modulation of Extinction of Drug Seeking by Deep Brain Stimulation of the Ventral Striatum

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Opioid use disorder: current trends and potential treatments

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Deep Brain Stimulation for Addictive Disorders—Where Are We Now?

Yuen, J., Kouzani, A. Z., Berk, M., Tye, S. J., Rusheen, A. E., Blaha, C. D., Bennet, K. E., Lee, K. H., Shin, H., Kim, J. H., et al. (2022) · Neurotherapeutics · doi:10.1007/s13311-022-01229-4 · Cited by 52 · see citing works

Forging Neuroimaging Targets for Recovery in Opioid Use Disorder

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Deep Brain Stimulation: A Potential Treatment for Dementia in Alzheimer's Disease (AD) and Parkinson's Disease Dementia (PDD)

Lv, Q., Du, A., Wei, W., Li, Y., Liu, G., & Wang, X. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00360 · Cited by 42 · see citing works

Deep Brain Stimulation Targeted at the Nucleus Accumbens Decreases the Potential for Pathologic Network Communication

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Neuromodulation for substance addiction in human subjects: A review

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Deep Brain Stimulation of Nucleus Accumbens for Methamphetamine Addiction: Two Case Reports

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Neurobiological mechanisms and related clinical treatment of addiction: a review

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Should impulse control disorders and dopamine dysregulation syndrome be indications for deep brain stimulation and intestinal levodopa?

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Outcomes of deep brain stimulation surgery for substance use disorder: a systematic review

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Brain stimulation in obesity

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Deep Brain Stimulation in Drug Addiction Treatment: Research Progress and Perspective

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Deep Brain Stimulation for Treatment-Refractory Mood and Obsessive-Compulsive Disorders

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Deep brain stimulation in addiction due to psychoactive substance use

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Deep brain stimulation of the orbitofrontal cortex prevents the development and reinstatement of morphine place preference

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Deep brain stimulation of the nucleus accumbens/ventral capsule for severe and intractable opioid and benzodiazepine use disorder.

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Fecal microbiota transplantation provides new insight into wildlife conservation

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Deep Brain Stimulation of Nucleus Accumbens with Anterior Capsulotomy for Drug Addiction: A Case Report

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Safety and Feasibility of Nucleus Accumbens Surgery for Drug Addiction: A Systematic Review

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Deep Brain Stimulation: Expanding Applications

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Neurosurgical treatment for addiction: lessons from an untold story in China and a path forward

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Surgical Approaches in Psychiatry: A Survey of the World Literature on Psychosurgery

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Robust clinical benefit of multi-target deep brain stimulation for treatment of Gilles de la Tourette syndrome and its comorbidities

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Postmortem volumetric analysis of the nucleus accumbens in male heroin addicts: implications for deep brain stimulation

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Deep brain stimulation of the nucleus accumbens shell attenuates cocaine withdrawal but increases cocaine self-administration, cocaine-induced locomotor activity, and GluR1/GluA1 in the central nucleus of the amygdala in male cocaine-dependent rats

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Deep brain stimulation for psychiatric disorders and behavioral/cognitive-related indications: Review of the literature and implications for treatment

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Is deep brain stimulation a treatment option for addiction?

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Distinct suppressing effects of deep brain stimulation in the orbitofrontal cortex on the development, extinction, and reinstatement of methamphetamine-seeking behaviors

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Deep Brain Stimulation for Obesity: From a Theoretical Framework to Practical Application

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A wide range of Deep Brain Stimulation of the nucleus accumbens shell time independently reduces the extinction period and prevents the reinstatement of methamphetamine-seeking behavior in rats

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Preventing morphine reinforcement with high‐frequency deep brain stimulation of the lateral hypothalamic area

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Looking beyond the opioid receptor: A desperate need for new treatments for opioid use disorder

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Role of functional imaging in the development and refinement of invasive neuromodulation for psychiatric disorders

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Reduced volumes of the external and internal globus pallidus in male heroin addicts: a postmortem study

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Clinical evaluation of deep brain stimulation of nucleus accumbens/anterior limb of internal capsule for opioid relapse prevention: protocol of a multicentre, prospective and double-blinded study

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A systematic review of deep brain stimulation for substance use disorders

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Death From Opioid Overdose After Deep Brain Stimulation: A Case Report

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Attitudes Toward Treating Addiction With Deep Brain Stimulation

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Potential brain recovery of frontostriatal circuits in heroin users after prolonged abstinence: A preliminary study

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Deep brain stimulation for opioid use disorder: A systematic review of preclinical and clinical evidence

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Advances in Brain Stimulation, Nanomedicine and the Use of Magnetoelectric Nanoparticles: Dopaminergic Alterations and Their Role in Neurodegeneration and Drug Addiction

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An implantable device for neuropsychiatric rehabilitation by chronic deep brain stimulation in freely moving rats

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Deep Brain Stimulation for Substance Use Disorders? An Exploratory Qualitative Study of Perspectives of People Currently in Treatment

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Optogenetically-inspired neuromodulation: Translating basic discoveries into therapeutic strategies

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Prefrontal network engagement by deep brain stimulation in limbic hubs

Allawala, A. B., Bijanki, K. R., Oswalt, D. N., Mathura, R. K., Adkinson, J. A., Pirtle, V., Shofty, B., Robinson, M. E., Harrison, M. T., Mathew, S. J., et al. (2024) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2023.1291315 · Cited by 8 · see citing works

How Treatment-Refractory Addiction Is Defined: A Scoping Review

Bormann, N. L., Burson, J. R., Burson, E. M., McGinnis, M. T., Karpyak, V. M., Coombes, B. J., Gold, M. S., & Oesterle, T. (2025) · Journal of Addiction Medicine · doi:10.1097/adm.0000000000001527 · Cited by 7 · see citing works

Innovative perspectives in limbic surgery using deep brain stimulation

Carrillo-Ruiz, J. D., Carrillo-Márquez, J. R., Beltrán, J. Q., Jiménez-Ponce, F., García‐Muñoz, L., Navarro-Olvera, J. L., Márquez-Franco, R., & Velasco, F. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1167244 · Cited by 7 · see citing works

The Network Systems Underlying Emotions: The Rational Foundation of Deep Brain Stimulation Psychosurgery

Vega-Zelaya, L., & Pastor, J. (2023) · Brain Sciences · doi:10.3390/brainsci13060943 · Cited by 7 · see citing works

Deep Brain Stimulation Compared With Contingency Management for the Treatment of Cocaine Use Disorders: A Threshold and Cost-Effectiveness Analysis

Kuijper, F. M., Mahajan, U. V., Ku, S., Barbosa, D. A. N., Alessi, S. M., Stein, S. C., Kampman, K. M., Bentzley, B. S., & Halpern, C. H. (2021) · Neuromodulation Technology at the Neural Interface · doi:10.1111/ner.13410 · Cited by 7 · see citing works

Modern neurosurgical techniques for psychiatric disorders

Salles, A. D., Lucena, L., Paranhos, T., Ferragut, M. A., de Oliveira‐Souza, R., & Gorgulho, A. A. (2022) · Progress in brain research · doi:10.1016/bs.pbr.2022.01.025 · Cited by 7 · see citing works

Neural circuits controlling choice behavior in opioid addiction

Chang, V. N., & Peters, J. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109407 · Cited by 7 · see citing works

Deep brain stimulation of the nucleus accumbens core but not shell reduces motivational components of heroin taking and seeking in rats

Schippers, M., Gaastra, M., Mesman, T. I., Schetters, D., van Mourik, Y., Denys, D. A. J. P., Pattij, T., & Vries, T. J. D. (2017) · Brain and Neuroscience Advances · doi:10.1177/2398212817711083 · Cited by 7 · see citing works

Effects of deep brain stimulation of the nucleus accumbens and anterior limb of the internal capsule on heroin addiction: Over five years of long-term follow-up in a prospective open-label pilot study

Ge, S., Wang, X., Chen, L., Li, N., Li, Y., Cai, Y., Wang, X., Li, W., Su, M., Zheng, Z., et al. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03635-6 · Cited by 6 · see citing works

Deep Brain Stimulation in Treatment-Resistant Psychiatric Disorders: Efficacy, Safety, and Future Directions

Khosravi, M. (2025) · Brain Sciences · doi:10.3390/brainsci15111244 · Cited by 6 · see citing works

Infralimbic deep brain stimulation: The impact of frequency and timing on extinction and reinstatement of morphine-seeking behaviors in male rats

Seddighfar, M., Bahmani, Z., & Haghparast, A. (2025) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2025.111383 · Cited by 5 · see citing works

Escalated oxycodone self-administration is associated with expression of voltage gated and calcium activated potassium channels in the mesocorticolimbic system in rats

Wabreha, A. Y., Adjei, N., Ladenheim, B., Cadet, J. L., & Daiwile, A. P. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1653356 · Cited by 5 · see citing works

Error-Related Activity in Striatal Local Field Potentials and Medial Frontal Cortex: Evidence From Patients With Severe Opioid Abuse Disorder

Sildatke, E., Schüller, T., Gründler, T. O. J., Ullsperger, M., Visser-Vandewalle, V. E. R. M., Huys, D., & Kuhn, J. (2021) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2020.627564 · Cited by 5 · see citing works

Picking a (neuroimmune) fight against fragile regulation of addiction

Kim, M. W., & Kipnis, J. (2023) · Cell · doi:10.1016/j.cell.2023.01.003 · Cited by 5 · see citing works

Deep Brain Stimulation

Hauser, S. R., Wilden, J. A., Batra, V., & Rodd, Z. A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-805373-7.00022-0 · Cited by 5 · see citing works

Distal Functional Connectivity of Known and Emerging Cortical Targets for Therapeutic Noninvasive Stimulation

Doñamayor, N., Baek, K., & Voon, V. (2017) · Cerebral Cortex · doi:10.1093/cercor/bhx331 · Cited by 5 · see citing works

Craving Prediction From fMRI Drug Cue Reactivity in Methamphetamine Use Disorder: A Parsimonious Neurobiological Model

Mahdavi‐Doost, H., Soleimani, G., Lim, K. O., & Ekhtiari, H. (2025) · Brain and Behavior · doi:10.1002/brb3.70991 · Cited by 4 · see citing works

Automated Monitoring and Clinical Notifications of Patient State for Neuropsychiatric Neuromodulation Studies*

Fra̧czek, T. M., Zhou, Y., Kutcher, T. P., Bechtold, R. A., Chamarthi, S., Vanegas‐Arroyave, N., Goodman, W. K., Sheth, S. A., Herron, J. A., & Provenza, N. R. (2025) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/embc58623.2025.11252732 · Cited by 4 · see citing works

Deep brain stimulation for the treatment of substance use disorders: a promising approach requiring caution

Sakai, J. T., Tanabe, J., Battula, S., Zipperly, M. E., Mikulich‐Gilbertson, S. K., Kern, D. S., Thompson, J. A., Ojemann, S., Raymond, K. M., Gerecht, P. D., et al. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1435109 · Cited by 4 · see citing works

Neuromodulation for Addiction

Kuhn, J., Möller, M., Lenartz, D., Bührle, C., & Visser-Vandewalle, V. E. R. M. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1408-1_17 · Cited by 4 · see citing works

Role of deep brain stimulation (DBS) in addiction disorders

Iqbal, J., Mansour, M. N. M., Saboor, H. A., Suyambu, J., Lak, M. A., Zeeshan, M. H., Hafeez, M. H., Arain, M. A., Mehmood, M., Mehmood, D., et al. (2023) · Surgical Neurology International · doi:10.25259/sni_662_2023 · Cited by 4 · see citing works

Deep brain stimulation for the treatment of addiction: basic and clinical studies and potential mechanisms of action

Pierce, R. C., & Vassoler, F. M. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3214-6 · Cited by 75 · see citing works

Deep brain stimulation as therapy against addiction

Algaba, L., & José, P. (2019)

Deep Brain Stimulation for the Treatment of Addiction

Voges, J., Ulf, M., Bogerts, B., & Hans-Joachim, H. (2014) · Frontiers in Human Neuroscience · doi:10.3389/conf.fnhum.2014.214.00009

Deep brain stimulation of the nucleus accumbens for the treatment of addiction

Müller, U., Voges, J., Steiner, J. H., Galazky, I., Heinze, H., Möller, M., Pisapia, J. M., Halpern, C. H., Caplan, A. L., Bogerts, B., et al. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06834.x · Cited by 120 · see citing works

Nucleus Accumbens as a Novel Target for Deep Brain Stimulation in the Treatment of Addiction: A Hypothesis on the Neurochemical and Morphological Basis

Vannemreddy, P. S. S. V., & Slavin, K. V. (2019) · Neurology India · doi:10.4103/0028-3886.271239 · Cited by 17 · see citing works