Cited by 104Sesquiterpenes and Asteraceae StudiesPhytochemistry and Biological ActivitiesPhytochemical compounds biological activities

Terpenoids and Flavonoids from Artemisia Species

Tang, Hai, Hu, Jun, Yang, Li, Tan, Ren·2000·Planta Medica

Abstract

A phytochemical reinvestigation of the aerial parts of Artemisia sieversiana gave a new guaianolide and two known flavones (chrysosplenetin and 5-hydroxy-3',4',6,7-tetramethoxyflavone). Antifungal fractions derived from the chloroform extract of A. annua afforded two cadinane derivatives (arteannuin B and artemisinin), oleanolic acid, beta-sitosterol, stigmasterol, and the four flavones artemetin, bonanzin, eupalitin and chrysosplenetin. Their structures were elucidated by spectral methods. All isolates from the two species were tested in vitro for antifungal activity. Arteannuin B, a main sesquiterpenoid in A. annua, showed antifungal activity against one human (Candida albicans, MIC: 100 micrograms/ml) and four plant pathogenic fungi (Gaeumannomyces graminis var. tritici, Rhizoctonia cerealis, Gerlachia nivalis and Verticillium dahliae, MICs: 150, 100, 150 and 100 micrograms/ml, respectively) whereas others showed no antifungal activity. The MIC value of ketoconazole to C. albicans was 1.0 microgram/ml, and those of triadimefon to G. graminis var. tritici and R. cerealis 150 and 100 micrograms/ml.

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Crossref · 10.1055/s-2000-8538

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Authors
Tang, H., Hu, J., Yang, L., & Tan, R.
Affiliations
  • Nanjing University (CN)
  • Lanzhou University (CN)
  • State Key Laboratory of Pharmaceutical Biotechnology (CN)
Venue
Planta Medica
Published
2000-12-31
Volume
66
Issue
04
Pages
391-393
ISSN
  • 0032-0943 (ISSN-L)
  • 1439-0221
OpenAlex
W2044390909
Cited by
104
References
0
Citations by year
2026: 2 · 2024: 6 · 2023: 3 · 2022: 4 · 2021: 3 · 2020: 7 · 2019: 3 · 2018: 2 · 2017: 5 · 2016: 1 · 2015: 4 · 2014: 9 · 2013: 5 · 2012: 2
FWCI
0.80
Type
journal article
Language
en
Open access
closed
Locations
  • Planta Medica (publishedVersion)
  • PubMed (publishedVersion)
  • Lanzhou University Institutional Repository (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Sesquiterpenes and Asteraceae Studies
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phytochemical compounds biological activities
Keywords
Artemisia sieversiana, Artemisia annua, guaianolides, flavones, arteannuin B, artemisinin, cadinane sesquiterpenoids, antifungal activity, Candida albicans, Gaeumannomyces graminis var. tritici, Rhizoctonia cerealis, Verticillium dahliae, phytochemistry
MeSH terms
Antifungal Agents, Flavonoids, Microbial Sensitivity Tests, Plants, Medicinal, Terpenes, Artemisia

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