Terpenoids and Flavonoids from Artemisia Species
Abstract
A phytochemical reinvestigation of the aerial parts of Artemisia sieversiana gave a new guaianolide and two known flavones (chrysosplenetin and 5-hydroxy-3',4',6,7-tetramethoxyflavone). Antifungal fractions derived from the chloroform extract of A. annua afforded two cadinane derivatives (arteannuin B and artemisinin), oleanolic acid, beta-sitosterol, stigmasterol, and the four flavones artemetin, bonanzin, eupalitin and chrysosplenetin. Their structures were elucidated by spectral methods. All isolates from the two species were tested in vitro for antifungal activity. Arteannuin B, a main sesquiterpenoid in A. annua, showed antifungal activity against one human (Candida albicans, MIC: 100 micrograms/ml) and four plant pathogenic fungi (Gaeumannomyces graminis var. tritici, Rhizoctonia cerealis, Gerlachia nivalis and Verticillium dahliae, MICs: 150, 100, 150 and 100 micrograms/ml, respectively) whereas others showed no antifungal activity. The MIC value of ketoconazole to C. albicans was 1.0 microgram/ml, and those of triadimefon to G. graminis var. tritici and R. cerealis 150 and 100 micrograms/ml.
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The most abundant sterols from A. annua are stigmasterol (570) and sitosterol (568), which are ubiquitous components of plant cell membranes.
“The most abundant sterols from A. annua are stigmasterol (570) and sitosterol (568) [96], which are ubiquitous components of plant cell membranes.”
From The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao) (2010) · cites this paper as [96]
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- Authors
- Tang, H., Hu, J., Yang, L., & Tan, R.
- Affiliations
- Nanjing University (CN)
- Lanzhou University (CN)
- State Key Laboratory of Pharmaceutical Biotechnology (CN)
- Venue
- Planta Medica
- Publisher
- Georg Thieme Verlag KG
- Published
- 2000-12-31
- Volume
- 66
- Issue
- 04
- Pages
- 391-393
- ISSN
- 0032-0943 (ISSN-L)
- 1439-0221
- OpenAlex
- W2044390909
- Cited by
- 104
- References
- 0
- Citations by year
- 2026: 2 · 2024: 6 · 2023: 3 · 2022: 4 · 2021: 3 · 2020: 7 · 2019: 3 · 2018: 2 · 2017: 5 · 2016: 1 · 2015: 4 · 2014: 9 · 2013: 5 · 2012: 2
- FWCI
- 0.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Planta Medica (publishedVersion)
- PubMed (publishedVersion)
- Lanzhou University Institutional Repository (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Sesquiterpenes and Asteraceae Studies
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phytochemical compounds biological activities
- Keywords
- Artemisia sieversiana, Artemisia annua, guaianolides, flavones, arteannuin B, artemisinin, cadinane sesquiterpenoids, antifungal activity, Candida albicans, Gaeumannomyces graminis var. tritici, Rhizoctonia cerealis, Verticillium dahliae, phytochemistry
- MeSH terms
- Antifungal Agents, Flavonoids, Microbial Sensitivity Tests, Plants, Medicinal, Terpenes, Artemisia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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