Physical Activity and Cardiovascular Disease
Abstract
This review, based on prospective epidemiological studies, indicates the existence of a dose-response relationship between physical activity and coronary heart disease (CHD), which is linear at least up to a certain level of activity. Leisure time physical activity is associated with about a 30-50% reduction in risk of CHD. The benefit of leisure-time physical activity is seen in both men and women, in middle-aged and older subjects and in men with established CHD. Several mechanisms, which could contribute to the protective effect of physical activity on CHD have been identified. Prospective studies suggest that physical activity is also associated with reduced risk of stroke. Overall, the evidence points to the benefit of continued regular moderate physical activity which does not need to be vigorous or sporting, and includes activities such as walking or gardening, readily attainable by large sections of the population. Current evidence supports the recommended guidelines of 30 minutes of moderate physical activity on most days of the week in both primary and secondary prevention of CHD.
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Physical inactivity is an independent risk factor for coronary heart disease.
“which is an independent risk factor for CHD [13,14].”
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Oguma, Y., & Shinoda-Tagawa, T. (2004) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2004.02.007 · Cited by 323 · see citing works
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Fischbacher, C., Hunt, S., & Alexander, L. (2004) · Journal of Public Health · doi:10.1093/pubmed/fdh158 · Cited by 267 · see citing works
Physical activity in primary and secondary prevention of cardiovascular disease: Overview updated
Alves, A., Viana, J., Cavalcante, S., Oliveira, N. L., Duarte, J., Mota, J., Oliveira, J., & Ribeiro, F. (2016) · World Journal of Cardiology · doi:10.4330/wjc.v8.i10.575 · Cited by 191 · see citing works
Inoue, M., Iso, H., Yamamoto, S., Kurahashi, N., Iwasaki, M., Sasazuki, S., & Tsugane, S. (2008) · Annals of Epidemiology · doi:10.1016/j.annepidem.2008.03.008 · Cited by 188 · see citing works
Warburton, D. E. R., Gledhill, N., Jamnik, V. K., Bredin, S. S. D., McKenzie, D. C., Stone, J., Charlesworth, S., & Shephard, R. J. (2011) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h11-062 · Cited by 156 · see citing works
Disease Diagnosis in Smart Healthcare: Innovation, Technologies and Applications
Chui, K. T., Alhalabi, W., Pang, S. S. H., de Pablos, P. O., Liu, R. W., & Zhao, M. (2017) · Sustainability · doi:10.3390/su9122309 · Cited by 147 · see citing works
“Other than diet modification, engaging in physical activity for at least 30 min every day will help to prevent stroke [86].”
BackgroundSport participation and positive development in older persons
Baker, J. R., Fraser-Thomas, J. L., Dionigi, R. A., & Horton, S. (2009) · European Review of Aging and Physical Activity · doi:10.1007/s11556-009-0054-9 · Cited by 125 · see citing works
“example, greater rates of physical activity are related to decreased sick days at work [67], lower rates of cardiovascular disease [68], and reduced total adiposity [69].”
BackgroundSelf-reported leisure time physical activity: a useful assessment tool in everyday health care
Rödjer, L., Jónsdóttir, I. H., Rosengren, A., Bjorck, L. M., Grimby, G., Thelle, D. S., Lappas, G., & Börjesson, M. (2012) · BMC Public Health · doi:10.1186/1471-2458-12-693 · Cited by 124 · see citing works
Hands, B. P., & PARKER, H. E. (2016) · Journal of Womens Health Issues and Care · doi:10.4172/2325-9795.1000238 · Cited by 115 · see citing works
“For example, low to moderate intensity physical activity, including brisk walking, provides protection from cardiovascular disease [22,25-28] and diabetes to a greater extent among women [29] compared to men.”
BackgroundPersonality, Physical Fitness, and Affective Response to Exercise among Adolescents
Schneider, M. L., & Graham, D. J. (2009) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31818de009 · Cited by 84 · see citing works
“Estimates based on the National Health and Nutrition Examination Survey (NHANES), using measured heights and weights, indicate that roughly 16 percent of American children and adolescents ages 2 – 19 years are overweight (26), placing them at increased risk for Type 2 diabetes (21) and heart disease (34).”
MethodBurton, N. W., Pakenham, K. I., & Brown, W. J. (2009) · BMC Public Health · doi:10.1186/1471-2458-9-427 · Cited by 76 · see citing works
Cardiovascular Disease Risk Factors
Amani, R., & Sharifi, N. (2012) · InTech eBooks · doi:10.5772/34374 · Cited by 80 · see citing works
The effect of physical exercise on reverse cholesterol transport
Leaf, D. A. (2003) · Metabolism · doi:10.1016/s0026-0495(03)00147-1 · Cited by 76 · see citing works
Turkbey, E. B., Jorgensen, N. W., Johnson, W. C., Bertoni, A. G., Polak, J. F., Roux, A. V. D., Tracy, R. P., Lima, J. A. C., & Bluemke, D. A. (2009) · Heart · doi:10.1136/hrt.2009.178426 · Cited by 74 · see citing works
“The non-linearity of relationships between exercise and left ventricular mass and volumes was expressed by a steeper slope at lower levels of exercise and a plateau at higher levels of exercise. This has not previously been described. One previous study reported a dose–response relationship between physical activity a…”
BackgroundDawson, J., Hillsdon, M. M., Boller, I., & Foster, C. E. (2007) · Journal of Aging and Physical Activity · doi:10.1123/japa.15.3.318 · Cited by 66 · see citing works
Echouffo-Tcheugui, J. B., Butler, J., Yancy, C. W., & Fonarow, G. C. (2015) · Circulation: Heart Failure · doi:10.1161/circheartfailure.115.002070 · Cited by 64 · see citing works
Hubbard, D. M., Colantonio, L. D., Tanner, R. M., Carson, A. P., Sakhuja, S., Jaeger, B. C., Carey, R. M., COHEN, L. P., Shimbo, D., Butler, M. J., et al. (2019) · Diabetes Care · doi:10.2337/dc19-1074 · Cited by 61 · see citing works
de Waard, M. C., & Duncker, D. J. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.91281.2008 · Cited by 61 · see citing works
Goodman, J. M., Thomas, S. G., & Burr, J. (2011) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h11-048 · Cited by 60 · see citing works
Batty, G. D., Shipley, M. J., Mika Kivimaki, B., Marmot, M. G., & Smith, G. D. (2010) · Annals of Epidemiology · doi:10.1016/j.annepidem.2010.03.014 · Cited by 59 · see citing works
Šprager, S., & Zazula, D. (2012) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2012.2213302 · Cited by 57 · see citing works
Dawson, J., Hillsdon, M. M., Boller, I., & Foster, C. E. (2007) · British Journal of Sports Medicine · doi:10.1136/bjsm.2006.033340 · Cited by 50 · see citing works
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Panter, J., Mytton, O. T., Sharp, S. J., Brage, S., Cummins, S., Laverty, A. A., Wijndaele, K., & Ogilvie, D. (2018) · Heart · doi:10.1136/heartjnl-2017-312699 · Cited by 45 · see citing works
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Fezeu, L., Balkau, B., Sobngwi, E., et al. (2010) · International Journal of Obesity · doi:10.1038/ijo.2009.256 · Cited by 45 · see citing works
Santos, M., Kitzman, D. W., Matsushita, K., Loehr, L. R., Sueta, C. A., & Shah, A. M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0165111 · Cited by 45 · see citing works
Effects of leisure-time physical activity on well-being among women: a 32-year perspective
Blomstrand, A., Björkelund, C., Ariai, N., et al. (2009) · Scandinavian Journal of Public Health · doi:10.1177/1403494809341092 · Cited by 40 · see citing works
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Shively, C. A., Register, T. C., Adams, M. R., Golden, D., Willard, S. L., & Clarkson, T. B. (2008) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31817eaf0b · Cited by 38 · see citing works
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BackgroundMartín-Sierra, A., Vancampfort, D., Probst, M., Bobes, J., Maurissen, K., Sweers, K., Schepper, E. D., & Hert, M. D. (2011) · PubMed · Cited by 32 · see citing works
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“266 Posttest 39 132 (102) 43 106 (164) IPAQ: Sitting time (min/week) Pretest 37 2,296 (1,176) 42 2,111 (978) 1.”
Gardening is beneficial for adult mental health: Scottish Health Survey, 2012–2013
Shiue, I. (2015) · Scandinavian Journal of Occupational Therapy · doi:10.3109/11038128.2015.1085596 · Cited by 25 · see citing works
“The benefit for cardiovascular disease of continued regular moderate physical activity that does not need to be vigorous or sporting and includes activities such as walking or gardening has been continuously noted in the scientific literature (13).”
BackgroundUthman, O. A. (2009) · Journal of Public Health · doi:10.1007/s10389-009-0251-z · Cited by 23 · see citing works
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BackgroundWeaver, A. M., Wellenius, G. A., Wu, W.-C., et al. (2017) · Environmental Health · doi:10.1186/s12940-017-0226-4 · Cited by 21 · see citing works
Miyagi, R., Sasawaki, Y., & Shiotani, H. (2018) · Chronobiology International · doi:10.1080/07420528.2018.1550422 · Cited by 20 · see citing works
Diet and lifestyle measures to protect the ageing heart.
Stanner, S. (2009) · British Journal of Community Nursing · doi:10.12968/bjcn.2009.14.5.42080 · Cited by 16 · see citing works
Correlates of Cardiovascular Disease Risk Scores in Women in Riyadh, Kingdom of Saudi Arabia
Alquaiz, A. M., Kazi, A., Qureshi, R., Siddiqui, A. R., Jamal, A. A., & Shaik, S. A. (2015) · Women & Health · doi:10.1080/03630242.2014.972020 · Cited by 18 · see citing works
Wennberg, P., Wensley, F., Johansson, L., Boman, K., Angelantonio, E. D., Rumley, A., Lowe, G. D. O., Hallmans, G., & Jansson, J. (2010) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/hjr.0b013e32832f3b11 · Cited by 17 · see citing works
Exercise training in adverse cardiac remodeling
Duncker, D. J., van Deel, E. D., de Waard, M. C., de Boer, M., Merkus, D., & van der Velden, J. (2014) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-014-1464-8 · Cited by 16 · see citing works
Refining the exercise prescription for hypertension
Elley, C. R., & Arroll, B. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67507-1 · Cited by 14 · see citing works
Motivators for physical activity in patients with minor stroke: a qualitative study
Krawcyk, R. S., Christoffersen, L. C., Danielsen, A. K., & Kruuse, C. R. (2022) · Disability and Rehabilitation · doi:10.1080/09638288.2022.2032409 · Cited by 14 · see citing works
Olafiranye, O., Jean‐Louis, G., Antwi, M., Zizi, F., Shaw, R., Brimah, P., & Ogedegbe, G. G. (2012) · Sleep Medicine · doi:10.1016/j.sleep.2012.01.015 · Cited by 11 · see citing works
“Individuals experiencing depression or life stress are likely to be functionally limited [23,24], which is an independent risk factor for CHD [26,27].”
BackgroundWogksch, M. D., Howell, C. R., Wilson, C. L., Partin, R. E., Ehrhardt, M. J., Krull, K. R., Brinkman, T. M., Mulrooney, D. A., Hudson, M. M., Robison, L. L., et al. (2018) · Pediatric Blood & Cancer · doi:10.1002/pbc.27506 · Cited by 13 · see citing works
Self-reported physical inactivity predicts survival after hospitalization for heart disease
Oerkild, B., Frederiksen, M. S., Hansen, J. F., & Prescott, E. (2011) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1177/1741826710389379 · Cited by 10 · see citing works
“In contrast, higher mortality was found among elderly performing vigorous activity compared to moderate activity in patients with established heart disease(2,3) and in healthy subjects.(15) In a review by Wannamethee et al.”
BackgroundInfluentialCoronary Heart Disease Risk Factors and Cardiovascular Risk in Physical Workers and Managers
Bugajska, J., Michalak, J. M., Jędryka-Góral, A., Sagan, A., & Konarska, M. (2009) · International Journal of Occupational Safety and Ergonomics · doi:10.1080/10803548.2009.11076786 · Cited by 9 · see citing works
Gerontofitnesz – A rendszeres testmozgás jótékony hatása az idősödő emberek testi-lelki egészségére
Csinády, A. (2019) · Magyar Gerontológia · doi:10.47225/mg/11/37-38./7904 · Cited by 10 · see citing works
Relation between bone density and certain parameters of lipid status in postmenopausal women
Dimić, A., Popovic, M., Tasic, I. S., et al. (2012) · Open Medicine · doi:10.2478/s11536-012-0044-6 · Cited by 7 · see citing works
Exercise benefits the cardiac, autonomic and inflammatory responses to organophosphate toxicity
Machi, J. F., Schmidt, R., Salgueiro, L. M., Stoyell‐Conti, F. F., Barboza, C. D. A., Hernandez, D. R., & Morris, M. (2019) · Toxicology Reports · doi:10.1016/j.toxrep.2019.06.015 · Cited by 6 · see citing works
Al‐Hamed, F. S., Kouniaris, S., Tamimi, I., Lordkipanidzé, M., Madathil, S. A., Kezouh, A., Karp, I., Nicolau, B. F., & Tamimi, F. (2021) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1002/trc2.12184 · Cited by 5 · see citing works
Hirooka, N., Takedai, T., & D’Amico, F. (2014) · Asia Pacific Family Medicine · doi:10.1186/1447-056x-13-3 · Cited by 4 · see citing works
Mariano, T. B., Castilho, A. C. S., Sabela, A. K. D. D. A., de Oliveira, A. C., Cury, S. S., Aguiar, A. F., Dias, R. D. J. D., Cicogna, A. C., Okoshi, K., Justulin, L. A., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0244768 · Cited by 4 · see citing works
THE HEART OF STRENGTH: THE STRONG BLACK WOMAN SCHEMA AND CARDIOVASCULAR DISEASE RISK
Abrams, J. A. (2015) · VCU Scholars Compass (Virginia Commonwealth University) · doi:10.25772/zsdp-0x86 · Cited by 4 · see citing works
Booth, J. N., Redmond, N., Sims, M., Shimbo, D., & Muntner, P. (2016) · BMC Cardiovascular Disorders · doi:10.1186/s12872-015-0182-2 · Cited by 4 · see citing works
Physical Activity at Adulthood and Old Age
Piedade, S. R., Inada, M. M., Laurito, G. M., Paiva, D. N. E., Fraga, G. P., Pagnano, R. G., de Andrade, A. L. L., & Cardoso, T. P. (2019) · Springer eBooks · doi:10.1007/978-3-030-10433-7_6 · Cited by 4 · see citing works
Kakuchaya, T. T., Dzhitava, T. G., Pachuashvili, N. V., Kuular, A. M., Domracheva, I. I., & Закарая, Н. Э. (2021) · Cardiosomatics · doi:10.17816/22217185.2021.4.201261 · Cited by 3 · see citing works
Exercise and peripheral vascular function in health and disease
Arce‐Esquivel, A. A. (2007) · doi:10.31390/gradschool_dissertations.72 · Cited by 2 · see citing works
Exercise Training and Adverse Cardiac Remodeling and Dysfunction in Mice
Duncker, D. J., van Deel, E. D., de Waard, M. C., & van der Velden, J. (2012) · Springer eBooks · doi:10.1007/978-1-4614-5203-4_14 · Cited by 1 · see citing works
Evaluation of the physical activity biography: sport and transport.
Rogen, S., Hofmann, P., Bauernhofer, T., & Müller, W. (2014) · Europe PMC (PubMed Central) · Cited by 1 · see citing works
Wennberg, P. (2009) · DiVA at Umeå University (Umeå University) · Cited by 1 · see citing works
Abekah‐Nkrumah, G. (2013) · Research Explorer (The University of Manchester) · Cited by 1 · see citing works
Community Approaches to Reduce the Risks of Cardiovascular Disease
Harrington, C. B., Eastman, M. L., & Linnan, L. A. (2013) · CRC Press eBooks · doi:10.1201/b13781-9 · Cited by 1 · see citing works
Cardiovascular Disease Risk Factors
(2005) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2005.09.041 · Cited by 1 · see citing works
Effect of Neighborhood Features on BMI of African American adolescents in South Los Angeles
Obiora-Ike, F. O. (2015)
Sánchez, E. D. L. C., Torres-Piles, S. T., Puértolas, B. C., Vivas, M. J. D., & Saavedra, J. M. (2006) · KRONOS · doi:10.64197/kronos.5.09-10.544
Li, Y. (2015) · Scholar Commons (University of South Carolina)
(2018) · Wiley eBooks · doi:10.1002/9781118829875.refs
(2005) · Wiley eBooks · doi:10.1002/9780470774663.refs
Impact of Risk Factors and Treatment in Coronary Heart Disease
Bjorck, L. M. (2008) · Gothenburg University Publications Electronic Archive (Gothenburg University)
- Authors
- Wannamethee, S. G., & Shaper, A. G.
- Affiliations
- The Royal Free Hospital (GB)
- ORCID
- Wannamethee, S. Goya
- Venue
- Seminars in Vascular Medicine
- Publisher
- Georg Thieme Verlag KG
- Published
- 2002
- Volume
- 02
- Issue
- 3
- Pages
- 257-266
- ISSN
- 1528-9648 (ISSN-L)
- 1529-3505
- OpenAlex
- W1539767705
- Cited by
- 70
- References
- 0
- Citations by year
- 2022: 1 · 2021: 3 · 2019: 4 · 2018: 4 · 2017: 3 · 2016: 4 · 2015: 6 · 2014: 3 · 2013: 2 · 2012: 6
- FWCI
- 1.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Seminars in Vascular Medicine (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Effects of Exercise
- Keywords
- physical activity, cardiovascular disease, coronary artery disease, stroke, dose-response relationship, leisure-time physical activity, moderate physical activity, primary prevention, secondary prevention, physical activity guidelines, protective mechanisms
- MeSH terms
- Aged, Aged, 80 and over, Cardiovascular Diseases, Coronary Disease, Female, Humans, Male, Middle Aged, Motor Activity, Peripheral Vascular Diseases, Stroke
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