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Antihyperglycemic Effect of Andrographolide in Streptozotocin-Induced Diabetic Rats
Abstract
The antihyperglycemic action of andrographolide, an active principle in the leaves of Andrographis paniculata (Burm. f.) Nees, was investigated in streptozotocin-induced diabetic rats (STZ-diabetic rats). Oral treatment of andrographolide decreased the plasma glucose concentrations of STZ-diabetic rats in a dose-dependent manner. Similar treatment with andrographolide also decreased the plasma glucose in normal rats and the maximal effect was more marked than that in STZ-diabetic rats. Andrographolide at the effective dose (1.5 mg/kg) significantly attenuated the increase of plasma glucose induced by an intravenous glucose challenge test in normal rats. In the isolated soleus muscle of STZ-diabetic rats, andrographolide enhanced the uptake of radioactive glucose in a concentration-dependent manner. Moreover, the mRNA and protein levels of the subtype 4 form of the glucose transporter (GLUT4) in soleus muscle were increased after repeated intravenous administration of andrographolide in STZ-diabetic rats for 3 days. These results suggest that andrographolide can increase the glucose utilization to lower plasma glucose in diabetic rats lacking insulin.
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Cited by
Subramanian, R., Asmawi, M. Z., & Sadikun, A. (2008) · Acta Biochimica Polonica · doi:10.18388/abp.2008_3087 · Cited by 363
Antidiabetic phytoconstituents and their mode of action on metabolic pathways
Bharti, S. K., Krishnan, S., Kumar, A., & Kumar, A. (2018) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/2042018818755019 · Cited by 222
Phytotherapy in diabetes: Review on potential mechanistic perspectives
El-Abhar, H. S., & Schaalan, M. F. (2014) · World Journal of Diabetes · doi:10.4239/wjd.v5.i2.176 · Cited by 145
Metadata
- Venue
- Planta Medica
- Publisher
- Georg Thieme Verlag KG
- Published
- 2003-12
- Volume
- 69
- Issue
- 12
- Pages
- 1075-1079
- ISSN
- 0032-0943 (ISSN-L)
- 1439-0221
- OpenAlex
- W1588108786
- Cited by
- 211
- References
- 0
- FWCI
- 6.91
- Type
- journal article
- Language
- en
- Open access
- closed
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