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Cited by 222Natural Antidiabetic Agents StudiesMedicinal Plant ResearchDiabetes Treatment and Management

Antidiabetic phytoconstituents and their mode of action on metabolic pathways

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Bharti, Sudhanshu Kumar, Krishnan, Supriya, Kumar, Ashwini, Kumar, Awanish·2018·Therapeutic Advances in Endocrinology and Metabolism
DOI 10.1177/2042018818755019PMC PMC5813859
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Abstract

Diabetes Mellitus, characterized by persistent hyperglycaemia, is a heterogeneous group of disorders of multiple aetiologies. It affects the human body at multiple organ levels thus making it difficult to follow a particular line of the treatment protocol and requires a multimodal approach. The increasing medical burden on patients with diabetes-related complications results in an enormous economic burden, which could severely impair global economic growth in the near future. This shows that today’s healthcare system has conventionally been poorly equipped towards confronting the mounting impact of diabetes on a global scale and demands an urgent need for newer and better options. The overall challenge of this field of diabetes treatment is to identify the individualized factors that can lead to improved glycaemic control. Plants are traditionally used worldwide as remedies for diabetes healing. They synthesize a diverse array of biologically active compounds having antidiabetic properties. This review is an endeavour to document the present armamentarium of antidiabetic herbal drug discovery and developments, highlighting mechanism-based antidiabetic properties of over 300 different phytoconstituents of various chemical categories from about 100 different plants modulating different metabolic pathways such as glycolysis, Krebs cycle, gluconeogenesis, glycogen synthesis and degradation, cholesterol synthesis, carbohydrate metabolism as well as peroxisome proliferator activated receptor activation, dipeptidyl peptidase inhibition and free radical scavenging action. The aim is to provide a rich reservoir of pharmacologically established antidiabetic phytoconstituents with specific references to the novel, cost-effective interventions, which might be of relevance to other low-income and middle-income countries of the world.

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Authors
Bharti, S. K., Krishnan, S., Kumar, A., & Kumar, A.
Affiliations
  • Patna University (IN)
  • Department of Biotechnology, National Institute of Technology, Raipur, Chhattisgarh, India
  • Department of Biotechnology, National Institute of Technology, GE Road, Raipur, Chhattisgarh, 492010, India
ORCID
Venue
Therapeutic Advances in Endocrinology and Metabolism
Publisher
SAGE Publications
Published
2018-02-12
Volume
9
Issue
3
Pages
81-100
ISSN
  • 2042-0188 (ISSN-L)
  • 2042-0196
DOI
10.1177/2042018818755019
PMC
PMC5813859
OpenAlex
W2791393203
Cited by
222
References
2
Citations by year
2026: 18 · 2025: 29 · 2024: 33 · 2023: 34 · 2022: 32 · 2021: 29 · 2020: 30 · 2019: 12 · 2018: 3 · 2017: 1
FWCI
2.85
Type
journal article
Language
en
Open access
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations
  • Therapeutic Advances in Endocrinology and Metabolism (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords
diabetes mellitus, herbal medicine, glycemic control, carbohydrate metabolism, gluconeogenesis, glycogen metabolism, cholesterol biosynthesis, PPAR activation, free radical scavenging, glycolysis, TCA cycle, medicinal plants

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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