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Cited by 152Natural Antidiabetic Agents StudiesDiet, Metabolism, and DiseaseMetabolism, Diabetes, and Cancer

The DOI matches its Crossref record.

Cinnamon Extract Prevents the Insulin Resistance Induced by a High-fructose Diet

Bolin Qin, Masaru Nagasaki, M.  Ren, Gustavo Bajotto, Y. Oshida, Youichi Sato·2004·Hormone and Metabolic Research
DOI 10.1055/s-2004-814223
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Abstract

The aim of this study was to determine whether cinnamon extract (CE) would improve the glucose utilization in normal male Wistar rats fed a high-fructose diet (HFD) for three weeks with or without CE added to the drinking water (300 mg/kg/day). In vivo glucose utilization was measured by the euglycemic clamp technique. Further analyses on the possible changes in insulin signaling occurring in skeletal muscle were performed afterwards by Western blotting. At 3 mU/kg/min insulin infusions, the decreased glucose infusion rate (GIR) in HFD-fed rats (60 % of controls, p < 0.01) was improved by CE administration to the same level of controls (normal chow diet) and the improving effect of CE on the GIR of HFD-fed rats was blocked by approximately 50 % by N-monometyl-L-arginine. The same tendency was found during the 30 mU/kg/min insulin infusions. There were no differences in skeletal muscle insulin receptor (IR)-beta, IR substrate (IRS)-1, or phosphatidylinositol (PI) 3-kinase protein content in any groups. However, the muscular insulin-stimulated IR-beta and IRS-1 tyrosine phosphorylation levels and IRS-1 associated with PI 3-kinase in HFD-fed rats were only 70 +/- 9 %, 76 +/- 5 %, and 72 +/- 6 % of controls (p < 0.05), respectively, and these decreases were significantly improved by CE treatment. These results suggest that early CE administration to HFD-fed rats would prevent the development of insulin resistance at least in part by enhancing insulin signaling and possibly via the NO pathway in skeletal muscle.

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Metadata

Authors
Qin, B., Nagasaki, M., Ren, M., Bajotto, G., Oshida, Y., & Sato, Y.
Affiliations
  • Nagoya University (JP)
  • Research Center of Health, Physical Fitness and Sports, Nagoya University (JP)
ORCID
Venue
Hormone and Metabolic Research
Publisher
Georg Thieme Verlag KG
Published
2004-02
Volume
36
Issue
2
Pages
119-125
ISSN
  • 0018-5043 (ISSN-L)
  • 1439-4286
DOI
10.1055/s-2004-814223
OpenAlex
W199222752
Cited by
152
References
0
Citations by year
2026: 3 · 2025: 6 · 2024: 3 · 2023: 3 · 2022: 5 · 2021: 6 · 2020: 5 · 2019: 3 · 2018: 4 · 2017: 6 · 2016: 7 · 2015: 8 · 2014: 7 · 2013: 6 · 2012: 8
FWCI
4.55
Type
journal article
Language
en
Open access
closed
Locations
  • Hormone and Metabolic Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords
cinnamon extract, insulin resistance, high-fructose diet, glucose utilization, skeletal muscle, insulin signaling, IRS-1 tyrosine phosphorylation, PI3-kinase, nitric oxide pathway, L-NMMA, insulin receptor beta
MeSH terms
Animals, Blood Glucose, Body Weight, Cinnamomum zeylanicum, Diet, Dose-Response Relationship, Drug, Eating, Fatty Acids, Nonesterified, Fructose, Glucose, Insulin, Insulin Resistance, Male, Phosphoproteins, Phosphorylation, Plant Extracts, Receptor, Insulin, Tyrosine, Glucose Clamp Technique, Rats, Wistar, Rats, Insulin Receptor Substrate Proteins

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