The DOI matches its Crossref record.
Cinnamon Extract Prevents the Insulin Resistance Induced by a High-fructose Diet
Abstract
The aim of this study was to determine whether cinnamon extract (CE) would improve the glucose utilization in normal male Wistar rats fed a high-fructose diet (HFD) for three weeks with or without CE added to the drinking water (300 mg/kg/day). In vivo glucose utilization was measured by the euglycemic clamp technique. Further analyses on the possible changes in insulin signaling occurring in skeletal muscle were performed afterwards by Western blotting. At 3 mU/kg/min insulin infusions, the decreased glucose infusion rate (GIR) in HFD-fed rats (60 % of controls, p < 0.01) was improved by CE administration to the same level of controls (normal chow diet) and the improving effect of CE on the GIR of HFD-fed rats was blocked by approximately 50 % by N-monometyl-L-arginine. The same tendency was found during the 30 mU/kg/min insulin infusions. There were no differences in skeletal muscle insulin receptor (IR)-beta, IR substrate (IRS)-1, or phosphatidylinositol (PI) 3-kinase protein content in any groups. However, the muscular insulin-stimulated IR-beta and IRS-1 tyrosine phosphorylation levels and IRS-1 associated with PI 3-kinase in HFD-fed rats were only 70 +/- 9 %, 76 +/- 5 %, and 72 +/- 6 % of controls (p < 0.05), respectively, and these decreases were significantly improved by CE treatment. These results suggest that early CE administration to HFD-fed rats would prevent the development of insulin resistance at least in part by enhancing insulin signaling and possibly via the NO pathway in skeletal muscle.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“It has been shown that cinnamon prevents the development of insulin resistance in rats fed a high-fructose diet by enhancing the insulin signaling, possibly via the nitric oxide pathway in skeletal muscle (10).”
From Effect of cinnamon on postprandial blood glucose, gastric emptying, and satiety in healthy subjects (2007) · cites this paper as [10]
Citations
Cited by
Sorted by citations
Impact of Dietary Polyphenols on Carbohydrate Metabolism
Hanhineva, K., Törrönen, R., Bondia‐Pons, I., Pekkinen, J., Kolehmainen, M., Mykkänen, H. M., & Poutanen, K. S. (2010) · International Journal of Molecular Sciences · doi:10.3390/ijms11041365 · Cited by 1,203
Polyphenols and Glycemic Control
Kim, Y., Keogh, J. B., & Clifton, P. M. (2016) · Nutrients · doi:10.3390/nu8010017 · Cited by 583
Traditional Chinese Medicine in Treatment of Metabolic Syndrome
Yin, J., Zhang, H., & Ye, J. (2008) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/187153008784534330 · Cited by 377
Effects of a cinnamon extract on plasma glucose, HbA1c, and serum lipids in diabetes mellitus type 2
Mang, B., Wolters, M., Schmitt, B., Kelb, K., Lichtinghagen, R., Stichtenoth, D. O., & Hahn, A. (2006) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2006.01629.x · Cited by 354
Gruenwald, J., Freder, J., & Armbruester, N. (2010) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390902773052 · Cited by 377
Metadata
- Authors
- Qin, B., Nagasaki, M., Ren, M., Bajotto, G., Oshida, Y., & Sato, Y.
- Affiliations
- Nagoya University (JP)
- Research Center of Health, Physical Fitness and Sports, Nagoya University (JP)
- Venue
- Hormone and Metabolic Research
- Publisher
- Georg Thieme Verlag KG
- Published
- 2004-02
- Volume
- 36
- Issue
- 2
- Pages
- 119-125
- ISSN
- 0018-5043 (ISSN-L)
- 1439-4286
- OpenAlex
- W199222752
- Cited by
- 152
- References
- 0
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 3 · 2023: 3 · 2022: 5 · 2021: 6 · 2020: 5 · 2019: 3 · 2018: 4 · 2017: 6 · 2016: 7 · 2015: 8 · 2014: 7 · 2013: 6 · 2012: 8
- FWCI
- 4.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hormone and Metabolic Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- cinnamon extract, insulin resistance, high-fructose diet, glucose utilization, skeletal muscle, insulin signaling, IRS-1 tyrosine phosphorylation, PI3-kinase, nitric oxide pathway, L-NMMA, insulin receptor beta
- MeSH terms
- Animals, Blood Glucose, Body Weight, Cinnamomum zeylanicum, Diet, Dose-Response Relationship, Drug, Eating, Fatty Acids, Nonesterified, Fructose, Glucose, Insulin, Insulin Resistance, Male, Phosphoproteins, Phosphorylation, Plant Extracts, Receptor, Insulin, Tyrosine, Glucose Clamp Technique, Rats, Wistar, Rats, Insulin Receptor Substrate Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
