Cinnamon extract (traditional herb) potentiates in vivo insulin-regulated glucose utilization via enhancing insulin signaling in rats
Abstract
Cinnamon has been shown to potentiate the insulin effect through upregulation of the glucose uptake in cultured adipocytes. In the present study, we evaluated the effect of the cinnamon extract on the insulin action in awaked rats by the euglycemic clamp and further analyzed possible changes in insulin signaling occurred in skeletal muscle. The rats were divided into saline and cinnamon extract (30 and 300 mg/kg BW-doses: C30 and C300) oral administration groups. After 3-weeks, cinnamon extract treated rats showed a significantly higher glucose infusion rate (GIR) at 3 mU/kg per min insulin infusions compared with controls (118 and 146% of controls for C30 and C300, respectively). At 30 mU/kg per min insulin infusions, the GIR in C300 rats was increased 17% over controls. There were no significant differences in insulin receptor (IR)-beta, IR substrate (IRS)-1, and phosphatidylinositol (PI) 3-kinase protein content between C300 rats and controls. However, the skeletal muscle insulin-stimulated IR-beta and the IRS-1 tyrosine phosphorylation levels in C300 rats were 18 and 33% higher, respectively, added to 41% higher IRS-1/PI 3-kinase association. These results suggest that the cinnamon extract would improve insulin action via increasing glucose uptake in vivo, at least in part through enhancing the insulin-signaling pathway in skeletal muscle.
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Cinnamon is reported to boost insulin receptor activity by raising phosphorylated IRS-1 and PI 3-kinase binding, which increases cellular glucose uptake.
“Cinnamon has also been shown to stimulate the insulin receptor activity by increasing the concentrations of the phosphorylated intracellular protein IRS-1 and increasing the binding to PI 3-kinase, which leads to enhanced cellular glucose uptake (9).”
From Effect of cinnamon on postprandial blood glucose, gastric emptying, and satiety in healthy subjects (2007) · cites this paper as [9]
Both in vitro and in vivo animal studies have shown insulin-enhancing or insulin-like effects after cinnamon administration.
“Both in vitro and in vivo animal studies have shown insulin-enhancing or insulin-like effects after cinnamon administration [365,366,367].”
From Effects of diet, lifestyle, Chrononutrition and alternative dietary interventions on postprandial Glycemia and insulin resistance (2022) · cites this paper as [365]
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- Authors
- Qin, B., Nagasaki, M., Ren, M., Bajotto, G., Oshida, Y., & Sato, Y.
- Affiliations
- Nagoya University (JP)
- Research Center of Health, Physical Fitness and Sports, Nagoya University (JP)
- Venue
- Diabetes Research and Clinical Practice
- Publisher
- Elsevier BV
- Published
- 2003-12
- Volume
- 62
- Issue
- 3
- Pages
- 139-148
- ISSN
- 0168-8227 (ISSN-L)
- OpenAlex
- W2129941041
- Cited by
- 298
- References
- 42
- Citations by year
- 2025: 9 · 2024: 9 · 2023: 12 · 2022: 9 · 2021: 15 · 2020: 12 · 2019: 13 · 2018: 16 · 2017: 11 · 2016: 12 · 2015: 19 · 2014: 20 · 2013: 14 · 2012: 21
- FWCI
- 3.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes Research and Clinical Practice (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Pharmacology › Berberine and alkaloids research
- Keywords
- cinnamon extract, insulin sensitivity, insulin signaling, skeletal muscle, glucose uptake, insulin receptor beta, IRS-1, PI3-kinase, euglycemic clamp, glucose infusion rate, traditional herbal medicine, diabetes mellitus
- MeSH terms
- Animals, Blood Glucose, Body Weight, Cinnamomum zeylanicum, Dose-Response Relationship, Drug, Fatty Acids, Nonesterified, Glucose, Insulin, Male, Plant Extracts, Glucose Clamp Technique, Signal Transduction, Rats, Wistar, Muscle, Skeletal, Rats
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