Effects of a cinnamon extract on plasma glucose, HbA1c, and serum lipids in diabetes mellitus type 2
Abstract
Background According to previous studies, cinnamon may have a positive effect on the glycaemic control and the lipid profile in patients with diabetes mellitus type 2. The aim of this trial was to determine whether an aqueous cinnamon purified extract improves glycated haemoglobin A1c (HbA 1c), fasting plasma glucose, total cholesterol, low‐density lipoprotein (LDL), high‐density lipoprotein (HDL) and triacylglycerol concentrations in patients with type 2 diabetes. Methods A total of 79 patients with diagnosed diabetes mellitus type 2 not on insulin therapy but treated with oral antidiabetics or diet were randomly assigned to take either a cinnamon extract or a placebo capsule three times a day for 4 months in a double‐blind study. The amount of aqueous cinnamon extract corresponded to 3 g of cinnamon powder per day. Results The mean absolute and percentage differences between the pre‐ and post‐intervention fasting plasma glucose level of the cinnamon and placebo groups were significantly different. There was a significantly higher reduction in the cinnamon group (10·3%) than in the placebo group (3·4%). No significant intragroup or intergroup differences were observed regarding HbA 1c, lipid profiles or differences between the pre‐ and postintervention levels of these variables. The decrease in plasma glucose correlated significantly with the baseline concentrations, indicating that subjects with a higher initial plasma glucose level may benefit more from cinnamon intake. No adverse effects were observed. Conclusions The cinnamon extract seems to have a moderate effect in reducing fasting plasma glucose concentrations in diabetic patients with poor glycaemic control.
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Cinnamon extracts have been known for managing blood glucose.
“Cinnamon extracts have been known for managing blood glucose.”
Most clinical trials administering cinnamon as extracts, capsules or supplements at 0.5 g to 6 g per day in subjects with T2DM have reported a generally favorable effect of cinnamon on postprandial/fasting hyperglycemia and diurnal glucose fluctuations.
“Most of the studies have reported a generally favorable effect of cinnamon on postprandial/fasting hyperglycemia and diurnal glucose fluctuations [368,369,370,371,372,373,374,375].”
From Effects of diet, lifestyle, Chrononutrition and alternative dietary interventions on postprandial Glycemia and insulin resistance (2022) · cites this paper as [374]
Cites
Standards of Medical Care in Diabetes
Power, D. V. (2006) · Diabetes Care · doi:10.2337/diacare.29.02.06.dc05-1593 · Cited by 8,672 · see citing works
Standards of Medical Care in Diabetes–2006
American Diabetes Association (2006) · Diabetes Care · doi:10.2337/diacare.29.s1.06.s4 · Cited by 1,884 · see citing works
Poor Control of Risk Factors for Vascular Disease Among Adults With Previously Diagnosed Diabetes
Saydah, S. H. (2004) · JAMA · doi:10.1001/jama.291.3.335 · Cited by 1,357 · see citing works
Cinnamon improves glucose and lipids of people with type 2 diabetes
Khan, A., Safdar, M., Ali Khan, M. M., Khattak, K. N., & Anderson, R. A. (2003) · Diabetes Care · doi:10.2337/diacare.26.12.3215 · Cited by 981 · see citing works
Hoult, J. R. S., & Payá, M. (1996) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(95)02112-4 · Cited by 957 · see citing works
Anderson, R. A., Broadhurst, C. L., Polansky, M. M., Schmidt, W. F., Khan, A., Flanagan, V. P., Schoene, N. W., & Graves, D. J. (2004) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf034916b · Cited by 561 · see citing works
Insulin-like Biological Activity of Culinary and Medicinal Plant Aqueous Extracts in Vitro
Broadhurst, C. L., Polansky, M. M., & Anderson, R. A. (2000) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf9904517 · Cited by 429 · see citing works
A hydroxychalcone derived from cinnamon functions as a mimetic for insulin in 3T3-L1 adipocytes
Jarvill-Taylor, K. J., Anderson, R. A., & Graves, D. J. (2001) · Journal of the American College of Nutrition · doi:10.1080/07315724.2001.10719053 · Cited by 324 · see citing works
Qin, B., Nagasaki, M., Ren, M., Bajotto, G., Oshida, Y., & Sato, Y. (2003) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(03)00173-6 · Cited by 298 · see citing works
Imparl-Radosevich, J. M., Deas, S., Polansky, M. M., Baedke, D. A., Ingebritsen, T. S., Anderson, R. A., & Graves, D. J. (1998) · Hormone Research in Paediatrics · doi:10.1159/000023270 · Cited by 205 · see citing works
Lipoprotein abnormalities and their consequences for patients with type 2 diabetes
Krentz, A. J. (2003) · Diabetes Obesity and Metabolism · doi:10.1046/j.1462-8902.2003.0310.x · Cited by 205 · see citing works
Antidiabetic effect ofCinnamomum cassia andCinnamomum zeylanicum In vivo andIn vitro
Verspohl, E. J., Bauer, K., & Neddermann, E. (2005) · Phytotherapy Research · doi:10.1002/ptr.1643 · Cited by 172 · see citing works
Insulin potentiating factor and chromium content of selected foods and spices
Khan, A., Bryden, N. A., Polansky, M. M., & Anderson, R. A. (1990) · Biological Trace Element Research · doi:10.1007/bf02917206 · Cited by 171 · see citing works
Kidane, A. G., Salacinski, H., Tiwari, A., Bruckdorfer, K. R., & Seifalian, A. M. (2004) · Biomacromolecules · doi:10.1021/bm0344553 · Cited by 166 · see citing works
Dyslipidemia of the metabolic syndrome
Ruotolo, G., & Howard, B. V. (2002) · Current Cardiology Reports · doi:10.1007/s11886-002-0113-6 · Cited by 155 · see citing works
Cinnamon extract prevents the insulin resistance induced by a high-fructose diet
(2004) · Hormone and Metabolic Research · doi:10.1055/s-2004-814223 · Cited by 152 · see citing works
Lee, J.-S., Jeon, S.-M., Park, E.-M., Huh, T., Kwon, O., Lee, M., & Choi, M. (2003) · Journal of Medicinal Food · doi:10.1089/10966200360716599 · Cited by 150 · see citing works
Effect of improved diabetes control on the expression of lipoprotein lipase in human adipose tissue.
Simsolo, R. B., Ong, J., Saffari, B., & Kern, P. A. (1992) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41886-3 · Cited by 81 · see citing works
Contact and Systemic Contact-type Dermatitis to Spices
Dooms‐Goossens, A., Dubelloy, R., & Degreef, H. J. (1990) · Dermatologic Clinics · doi:10.1016/s0733-8635(18)30529-1 · Cited by 69 · see citing works
Effect of cumin, cinnamon, ginger, mustard and tamarind in induced hypercholesterolemic rats
Sambaiah, K., & Srinivasan, K. (1991) · Food / Nahrung · doi:10.1002/food.19910350112 · Cited by 66 · see citing works
Treatment of Diabetic Dyslipoproteinemia
Steinmetz, A. (2003) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-2003-41748 · Cited by 34 · see citing works
Oral leukoplakia caused by cinnamon food allergy.
Mihail, R. (1992) · PubMed · Cited by 29 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Cinnamon use in type 2 diabetes: an updated systematic review and meta-analysis
Allen, R. W., Schwartzman, E., Baker, W. L., Coleman, C. I., & Phung, O. J. (2013) · The Annals of Family Medicine · doi:10.1370/afm.1517 · Cited by 269 · see citing works
“2 g/d was associated with an increase in fasting plasma glucose levels,10,14 and hemoglobin A1c levels9,10; however, others have reported reductions in glycemic parameters at doses between 1 to 6 g/d6-9,12,13 and in hemoglobin A1c.(6-9,11-13) The same conflict occurs in lipid parameters, at 1 g/d total cholesterol,10…”
BackgroundAkilen, R., Tsiami, A., Devendra, D., & Robinson, N. (2010) · Diabetic Medicine · doi:10.1111/j.1464-5491.2010.03079.x · Cited by 230 · see citing works
Qin, B., Panickar, K. S., & Anderson, R. A. (2010) · Journal of Diabetes Science and Technology · doi:10.1177/193229681000400324 · Cited by 220 · see citing works
Sheng, X., Zhang, Y., Gong, Z., Huang, C., & Zang, Y. Q. (2008) · PPAR Research · doi:10.1155/2008/581348 · Cited by 203 · see citing works
Papakonstantinou, E., Oikonomou, C., Nychas, G., & Dimitriadis, G. D. (2022) · Nutrients · doi:10.3390/nu14040823 · Cited by 199 · see citing works
Zare, R., Nadjarzadeh, A., Zarshenas, M. M., Shams, M., & Heydari, M. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2018.03.003 · Cited by 188 · see citing works
Sharifi-Rad, J., Dey, A., Koirala, N., Shaheen, S., El Omari, N., Salehi, B., Goloshvili, T., Cirone Silva, N. C., Bouyahya, A., Vitalini, S., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.600139 · Cited by 183 · see citing works
Lu, T., Sheng, H., Wu, J., Cheng, Y., Zhu, J., & Chen, Y. (2012) · Nutrition Research · doi:10.1016/j.nutres.2012.05.003 · Cited by 178 · see citing works
Cinnamon in glycaemic control: Systematic review and meta analysis
Akilen, R., Tsiami, A., Devendra, D., & Robinson, N. (2012) · Clinical Nutrition · doi:10.1016/j.clnu.2012.04.003 · Cited by 124 · see citing works
Gupta Jain, S., Puri, S., Misra, A., Gulati, S., & Mani, K. (2017) · Lipids in Health and Disease · doi:10.1186/s12944-017-0504-8 · Cited by 115 · see citing works
Beejmohun, V., Peytavy-Izard, M., Mignon, C., Muscente-Paque, D., Deplanque, X., Ripoll, C., & Chapal, N. (2014) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-14-351 · Cited by 97 · see citing works
Solomon, T. P. J., & Blannin, A. K. (2009) · European Journal of Applied Physiology · doi:10.1007/s00421-009-0986-9 · Cited by 89 · see citing works
Talaei, B., Amouzegar, A., Sahranavard, S., Hedayati, M., Mirmiran, P., & Azizi, F. (2017) · Nutrients · doi:10.3390/nu9090991 · Cited by 82 · see citing works
“Moreover, although another study reported a significant difference based on FPG in both the case and control groups, they found no significant intra-group or inter-group differences regarding HbA1c level [16].”
BackgroundLiu, Y., Cotillard, A., Vatier, C., Bastard, J.-P., Fellahi, S., Stévant, M., Allatif, O., Langlois, C., Bieuvelet, S., Brochot, A., et al. (2015) · PLOS ONE · doi:10.1371/journal.pone.0138646 · Cited by 71 · see citing works
Magistrelli, A., & Chezem, J. C. (2012) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2012.07.037 · Cited by 56 · see citing works
Gu, D.-T., Tung, T.-H., Jiesisibieke, Z. L., Chien, C.-W., & Liu, W.-Y. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.790901 · Cited by 54 · see citing works
Protective effects of plant‐derived natural products on renal complications
Yaribeygi, H., Simental‐Mendía, L. E., Butler, A. E., & Sahebkar, A. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.27950 · Cited by 46 · see citing works
Wickenberg, J., Lindstedt, S., Berntorp, K., Nilsson, J., & Hlebowicz, J. (2012) · British Journal of Nutrition · doi:10.1017/s0007114511005113 · Cited by 34 · see citing works
Optimizing Non-Pharmacologic Management of Hypertriglyceridemia
Byrne, A., Makadia, S., Sutherland, A., & Miller, M. (2017) · Archives of Medical Research · doi:10.1016/j.arcmed.2017.11.017 · Cited by 27 · see citing works
Dietary supplements for diabetes: an evaluation of commonly used products
Shane-McWhorter, L. (2009) · Diabetes Spectrum · doi:10.2337/diaspect.22.4.206 · Cited by 20 · see citing works
- Authors
- Mang, B., Wolters, M., Schmitt, B., Kelb, K., Lichtinghagen, R., Stichtenoth, D. O., & Hahn, A.
- Affiliations
- Leibniz University Hannover (DE)
- Medizinische Hochschule Hannover (DE)
- Corresponding author
- Wolters, M.
- Venue
- European Journal of Clinical Investigation
- Publisher
- Wiley
- Published
- 2006-04-18
- Volume
- 36
- Issue
- 5
- Pages
- 340-344
- ISSN
- 0014-2972 (ISSN-L)
- 1365-2362
- OpenAlex
- W2146161717
- Cited by
- 354
- References
- 22
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 19 · 2023: 10 · 2022: 22 · 2021: 31 · 2020: 21 · 2019: 24 · 2018: 20 · 2017: 17 · 2016: 21 · 2015: 18 · 2014: 20 · 2013: 15 · 2012: 16
- FWCI
- 11.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Clinical Investigation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Health Sciences › Medicine › Surgery › Natural Products and Biological Research
- Keywords
- cinnamon extract, type 2 diabetes, fasting blood glucose, HbA1c, glycemic control, serum lipids, cholesterol, low-density lipoprotein, HDL cholesterol, triglycerides
- MeSH terms
- Aged, Blood Glucose, Cinnamomum zeylanicum, Diabetes Mellitus, Type 2, Double-Blind Method, Female, Glycated Hemoglobin, Humans, Lipids, Male, Phytotherapy, Middle Aged, Plant Extracts
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