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Cited by 77Autism Spectrum Disorder ResearchEpilepsy research and treatmentChild Nutrition and Feeding Issues

Epilepsy is not a prominent feature of primary autism.

Pavone, P., Incorpora, G., Fiumara, A., Parano, E., Trifiletti, R. R., Ruggieri, M.·2004·Neuropediatrics
DOI 10.1055/s-2004-821079
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Abstract

The authors report on a series of 72 patients (57 male, 15 female; aged from 4 to 21 years) affected by autism with the aim of evaluate their experience regarding the prevalence of seizure and/or epilepsy. Patients were divided into two groups: the first includes individuals (n = 54) affected by so-called idiopathic or primary autism which was further subdivided according to the grade of mental retardation (MR) and the second (n = 18) in which a known pathological event was associated to the autism (secondary autism). According to these results in the first group 12 % of autistic patients with moderate MR (i.e., IQ > 55) suffered from seizures but in three patients (9 %) they were occasional and only in one recurrent (i.e., epileptic) (3 %). Autistic patients with severe MR (i.e., IQ < 55) suffered from seizures in 20 % of the cases: in three the episodes were recurrent (15 %) and in one occasional (5 %). In the second group in which autism was associated to other morbidities 61 % (n = 11/18) had seizures, being recurrent in 10 (55 %). According to this series, in autism the risk of epilepsy is higher compared to the general population but it does not seem to be correlated to the autism itself, but rather to the associated co-morbidities and underlying brain dysfunction (overall prevalence of epilepsy in primary autism [4/54 or 7.4 %] vs. secondary autism [10/18 or 55 %]).

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  • Frequently encountered medical factors in ASD include seizures (particularly in children with severe intellectual disability, motor deficits, or a positive family history of epilepsy), other gastrointestinal symptoms, and sleep disturbances affecting daytime functioning.

    “Frequently encountered medical factors in ASD include: seizures, particularly in children who also have severe intellectual disability, motor deficits, or a positive family history of epilepsy 68 , 69 ; other gastrointestinal symptoms 57 , 70 ; and sleep disturbances affecting daytime functioning.”

    From Early Intervention for Children With Autism Spectrum Disorder Under 3 Years of Age: Recommendations for Practice and Research (2015) · cites this paper as [68]

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Authors
Pavone, P., Incorpora, G., Fiumara, A., Parano, E., Trifiletti, R. R., & Ruggieri, M.
Affiliations
  • University of Catania (IT)
  • New York Medical College (US)
ORCID
Venue
Neuropediatrics
Publisher
Georg Thieme Verlag KG
Published
2004-08
Volume
35
Issue
4
Pages
207-210
ISSN
  • 0174-304X (ISSN-L)
  • 1439-1899
DOI
10.1055/s-2004-821079
OpenAlex
W2047898380
Cited by
77
References
0
Citations by year
2026: 1 · 2024: 1 · 2023: 2 · 2022: 4 · 2021: 2 · 2020: 1 · 2019: 4 · 2018: 3 · 2017: 3 · 2016: 7 · 2015: 5 · 2014: 1 · 2013: 3 · 2012: 3
FWCI
2.18
Type
journal article
Language
de
Open access
closed
Locations
  • Neuropediatrics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
  • Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
Keywords
autism spectrum disorder, epilepsy, seizures, intellectual disability, comorbidities, epilepsy prevalence, brain dysfunction
MeSH terms
Adolescent, Adult, Autistic Disorder, Brain, Child, Child, Preschool, Epilepsy, Female, Humans, Male, Intellectual Disability, Radiography, Risk Factors, Severity of Illness Index

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