The DOI matches its Crossref record.
Brine Shrimp: A Convenient General Bioassay for Active Plant Constituents
Abstract
A method, utilizing brine shrimp ( Artemia salina L EACH ), is proposed as a simple bioassay for natural product research. The procedure determines LC 50 values in µg/ml of active compounds and extracts in the brine medium. Activities of a broad range of known active compounds are manifested as toxicity to the shrimp. Screening results with seed extracts of 41 species of Euphorbiaceae were compared with 9KB and 9PS cytotoxicities. The method is rapid, reliable, inexpensive, and convenient as an in-house general bioassay tool. Key Word Index Artemia salina - Brine shrimp - Bioassay methods - Euphorbiaceae seeds - 9KB and 9PS cytotoxicities
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Bioactivities from marine algae of the genus Gracilaria
De Almeida, C. L. F., De S. Falcão, H., De M. Lima, G. R., De A. Montenegro, C., Lira, N. S., De Athayde-Filho, P. F., Rodrigues, L. C., De Souza, M. D. F. V., Barbosa-Filho, J. M., & Batista, L. M. (2011) · International Journal of Molecular Sciences · doi:10.3390/ijms12074550 · Cited by 252
Kapadia, G. J., Azuine, M. A., Tokuda, H., Takasaki, M., Mukainaka, T., Konoshima, T., & Nishino, H. (2002) · Pharmacological Research · doi:10.1006/phrs.2002.0992 · Cited by 238
Almeida, E. J. R., & Corso, C. R. (2014) · Chemosphere · doi:10.1016/j.chemosphere.2014.04.060 · Cited by 191
Nejrotti, S., Antenucci, A., Pontremoli, C., Gontrani, L., Barbero, N., Carbone, M., & Bonomo, M. (2022) · ACS Omega · doi:10.1021/acsomega.2c06140 · Cited by 111
Toxicity of clove essential oil and its ester eugenyl acetate against Artemia salina
Cansian, R. L., Vanin, A. B., Orlando, T., Piazza, S. P., Puton, B. M. S., Cardoso, R. I., Gonçalves, I. L., Honaiser, T. C., Paroul, N., & Oliveira, D. (2017) · Brazilian Journal of Biology · doi:10.1590/1519-6984.12215 · Cited by 67
Metadata
- Authors
- Meyer, B., Ferrigni, N., Putnam, J., Jacobsen, L., Nichols, D., & McLaughlin, J.
- Venue
- Planta Medica
- Publisher
- Georg Thieme Verlag KG
- Published
- 1982-05
- Volume
- 45
- Issue
- 05
- Pages
- 31-34
- ISSN
- 0032-0943 (ISSN-L)
- 1439-0221
- OpenAlex
- W2074509460
- Cited by
- 4,831
- References
- 0
- FWCI
- 1.15
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Brine Shrimp: A Convenient General Bioassay for Active Plant Constituents. https://app.cochat.ai/papers/10.1055/s-2007-971236
- The paper
- Meyer, B., Ferrigni, N., Putnam, J., Jacobsen, L., Nichols, D., & McLaughlin, J. (1982). Brine Shrimp: A Convenient General Bioassay for Active Plant Constituents. Planta Medica. https://doi.org/10.1055/s-2007-971236
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
