Cited by 252Seaweed-derived Bioactive CompoundsMarine Sponges and Natural ProductsMarine and coastal plant biology

Bioactivities from marine algae of the genus Gracilaria

Open access
De Almeida, Cynthia Layse F., De S. Falcão, Heloina, De M. Lima, Gedson R., De A. Montenegro, Camila, Lira, Narlize S., De Athayde-Filho, Petrônio F., Rodrigues, Luis C., De Souza, Maria de Fátima V. +2 more·2011·International Journal of Molecular Sciences

Abstract

Seaweeds are an important source of bioactive metabolites for the pharmaceutical industry in drug development. Many of these compounds are used to treat diseases like cancer, acquired immune-deficiency syndrome (AIDS), inflammation, pain, arthritis, as well as viral, bacterial, and fungal infections. This paper offers a survey of the literature for Gracilaria algae extracts with biological activity, and identifies avenues for future research. Nineteen species of this genus that were tested for antibacterial, antiviral, antifungal, antihypertensive, cytotoxic, spermicidal, embriotoxic, and anti-inflammatory activities are cited from the 121 references consulted.

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Crossref · 10.3390/ijms12074550

Cites

112 of 112 references verified0 citation errors · 0 not checkable

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  • Macroalgae also produce antimicrobial compounds, so it is possible that the normal intestinal microbiota of manatees was affected by a high macroalgal intake, with an associated increase in Clostridiales.

    “Macroalgae also produce antimicrobial compounds (de Almeida et al., 2011), so it is possible that the normal intestinal microbiota of manatees was affected by a high macroalgal intake, with an associated increase in Clostridiales.”
  • Extracts from red algae administered to female rats in the first seven days of pregnancy have post-coital contraceptive protection without relevant adverse effects.

    “Different studies [49,50] with extracts from red algae were carried out. These extracts were administrated to female rats in the first seven days of their pregnancies. As result, it was demonstrated that these extracts have post-coital contraceptive protection in the rats without showing any relevant adverse effect.”

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Cites

1 retracted

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1 of the 113 references couldn’t be matched to a known paper.

Research works printed but not linked: 3

  1. [32]Khotimchenko SV Vaskovsky VE Titlyanavo TV Fatty acids of marine algae from the 12 substances from marine algae Puerto Rico Antimicrob. Agents Chemother 1963 161 68 72 14274985
  2. [76]Chenieux JC Verbist JF Biard JF Clement E Le Boterff J Maupas P Lecocq M Seaweeds of French atlantic coast with antimitotic activity Planta Med 1980 40 152 162 7454880
  3. [110]Laserna EC Veroy RL Luistro AH Cajipe GJB Extracts from some red and brown seaweeds of the Philippines Tenth International Seaweed Symposium Levring T Walter de Gruyter & Co Berlin, Germany 1980 443 448

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Authors
De Almeida, C. L. F., De S. Falcão, H., De M. Lima, G. R., De A. Montenegro, C., Lira, N. S., De Athayde-Filho, P. F., Rodrigues, L. C., De Souza, M. D. F. V., Barbosa-Filho, J. M., & Batista, L. M.
Affiliations
  • Department of Pharmaceutical Sciences, Laboratory of Pharmaceutical Technology, Federal University of Paraiba, João Pessoa, PB 58051-900, Brazil
  • Universidade Federal da Paraíba (BR)
Corresponding author
Batista, Leônia M.
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2011-07-15
Volume
12
Issue
7
Pages
4550-4573
ISSN
1422-0067 (ISSN-L)
OpenAlex
W2080981798
Cited by
252
References
113
Citations by year
2026: 8 · 2025: 14 · 2024: 15 · 2023: 21 · 2022: 31 · 2021: 23 · 2020: 16 · 2019: 28 · 2018: 17 · 2017: 10 · 2016: 13 · 2015: 17 · 2014: 10 · 2013: 13 · 2012: 13
FWCI
1.22
Type
journal article
Language
en
Open access
Locations
  • International Journal of Molecular Sciences (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico
  • Fundação de Apoio à Pesquisa do Estado da Paraíba
Topics
  • Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
  • Physical Sciences › Earth and Planetary Sciences › Oceanography › Marine and coastal plant biology
Keywords
Gracilaria, red algae, marine algae, bioactive metabolites, antibacterial activity, antiviral activity, antifungal activity, antihypertensive effect, cytotoxicity, spermicidal activity, embryotoxicity, anti-inflammatory activity, drug development
MeSH terms
Animals, Anti-Infective Agents, Anti-Inflammatory Agents, Anticonvulsants, Bacteria, Cell Survival, DNA Viruses, Fungi, Humans, Nervous System, Plant Extracts, Platelet Aggregation, RNA Viruses, Gracilaria

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