Bioactivities from marine algae of the genus Gracilaria
Open accessAbstract
Seaweeds are an important source of bioactive metabolites for the pharmaceutical industry in drug development. Many of these compounds are used to treat diseases like cancer, acquired immune-deficiency syndrome (AIDS), inflammation, pain, arthritis, as well as viral, bacterial, and fungal infections. This paper offers a survey of the literature for Gracilaria algae extracts with biological activity, and identifies avenues for future research. Nineteen species of this genus that were tested for antibacterial, antiviral, antifungal, antihypertensive, cytotoxic, spermicidal, embriotoxic, and anti-inflammatory activities are cited from the 121 references consulted.
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Macroalgae also produce antimicrobial compounds, so it is possible that the normal intestinal microbiota of manatees was affected by a high macroalgal intake, with an associated increase in Clostridiales.
“Macroalgae also produce antimicrobial compounds (de Almeida et al., 2011), so it is possible that the normal intestinal microbiota of manatees was affected by a high macroalgal intake, with an associated increase in Clostridiales.”
From Novel Lethal Clostridial Infection in Florida Manatees (Trichechus manatus latirostris): Cause of the 2013 Unusual Mortality Event in the Indian River Lagoon (2022) · cites this paper as de Almeida et al., 2011
Extracts from red algae administered to female rats in the first seven days of pregnancy have post-coital contraceptive protection without relevant adverse effects.
“Different studies [49,50] with extracts from red algae were carried out. These extracts were administrated to female rats in the first seven days of their pregnancies. As result, it was demonstrated that these extracts have post-coital contraceptive protection in the rats without showing any relevant adverse effect.”
From The Potential of Seaweeds as a Source of Functional Ingredients of Prebiotic and Antioxidant Value (2019) · cites this paper as [50]
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Screening of Marine Bioactive Antimicrobial Compounds for Plant Pathogens
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“…wide range of bioactive compounds with toxic and cytostatic, antiviral, antihelmintic, antifungal, or antibacterial activity (Higa and Kuniyoshi, 2000; de Almeida et al., 2011; Kumar and Sharma, 2021), no negative effects associated with the ingestion of macroalgae have been documented in manatees.”
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- Authors
- De Almeida, C. L. F., De S. Falcão, H., De M. Lima, G. R., De A. Montenegro, C., Lira, N. S., De Athayde-Filho, P. F., Rodrigues, L. C., De Souza, M. D. F. V., Barbosa-Filho, J. M., & Batista, L. M.
- Affiliations
- Department of Pharmaceutical Sciences, Laboratory of Pharmaceutical Technology, Federal University of Paraiba, João Pessoa, PB 58051-900, Brazil
- Universidade Federal da Paraíba (BR)
- Corresponding author
- Batista, Leônia M.
- ORCID
- Batista, Leônia M.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2011-07-15
- Volume
- 12
- Issue
- 7
- Pages
- 4550-4573
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC3155369
- OpenAlex
- W2080981798
- Cited by
- 252
- References
- 113
- Citations by year
- 2026: 8 · 2025: 14 · 2024: 15 · 2023: 21 · 2022: 31 · 2021: 23 · 2020: 16 · 2019: 28 · 2018: 17 · 2017: 10 · 2016: 13 · 2015: 17 · 2014: 10 · 2013: 13 · 2012: 13
- FWCI
- 1.22
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação de Apoio à Pesquisa do Estado da Paraíba
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
- Physical Sciences › Earth and Planetary Sciences › Oceanography › Marine and coastal plant biology
- Keywords
- Gracilaria, red algae, marine algae, bioactive metabolites, antibacterial activity, antiviral activity, antifungal activity, antihypertensive effect, cytotoxicity, spermicidal activity, embryotoxicity, anti-inflammatory activity, drug development
- MeSH terms
- Animals, Anti-Infective Agents, Anti-Inflammatory Agents, Anticonvulsants, Bacteria, Cell Survival, DNA Viruses, Fungi, Humans, Nervous System, Plant Extracts, Platelet Aggregation, RNA Viruses, Gracilaria
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