CoChat
Sign Up
Cited by 31Neonatal and fetal brain pathologyNeonatal Health and BiochemistryInfant Development and Preterm Care

The predictive value of elevation in specific serum enzymes for subsequent development of hypoxic-ischemic encephalopathy or intraventricular hemorrhage in full-term and premature asphyxiated newborns

Lackmann, G., Töllner, U.·1995·Neuropediatrics
DOI 10.1055/s-2007-979752
Open this paper in CoChat — free account

Abstract

Serum lactate dehydrogenase (LDH), aspartate aminotransferase (ASAT), and hydroxybutyrate dehydrogenase (HBDH) activities are significantly elevated in asphyxiated newborns within the first days of life. The approach of the present study was to evaluate firstly if serum levels of these enzymes correlate with the development of hypoxic-ischemic encephalopathy (HIE) and periventricular-intraventricular hemorrhage (PIVH) in full-term and premature asphyxiated newborns, and secondly if postnatally elevated enzyme activities could be predictive for these disorders. ASAT, LDH and HBDH activities were measured in 98 asphyxiated newborns. Blood samples were taken serially at five fixed times: 0 (cord), 12, 24, 72, and 144 hours post partum. All newborns were examined for the development of HIE and PIVH using standardized scoring systems. Fifty percent of the newborns were full-term and 50% were premature. Ten of the full-term (20.4%) and 21 (42.8%) of the premature newborns developed HIE. Nineteen newborns (19.4%) suffered PIVH (full-term/premature, 7/12). The full-term asphyxiated newborns with HIE or PIVH showed significantly elevated ASAT, LDH, and HBDH activities within the first 72 hours of life. In case of the premature asphyxiated newborns, the enzyme activities did not differ significantly between the study groups. The overall predictive values showed a high sensitivity (HIE/PIVH, 90.0%/71.4%), a high specificity (71.0%/88.1%), an acceptable negative predictive value (44.9%/50.0%), and a high positive predictive value (96.5%/94.9%) for the development of HIE and PIVH in full-term asphyxiated newborns. It is concluded that measurements of ASAT, LDH, and HBDH activities are reliable predictors for the development of HIE and PIVH in full-term asphyxiated newborns.(ABSTRACT TRUNCATED AT 250 WORDS)

Integrity signals

Registry

Crossref · 10.1055/s-2007-979752

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • In Töllner's study, a significant difference in LDH activity between neonates with mild, moderate, or severe HIE and controls was demonstrated only in the 12-72 hour postpartum interval.

    “Töllner 125 collected neonatal blood from 0 (cord blood) to 144 hours postpartum, but only in the interval of 12 to 72 hours could a significant difference in LDH activity be demonstrated between neonates with mild, moderate, or severe HIE and the controls.”

    From Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility. (2023) · cites this paper as [125]

Cited by

Sorted by citations

Related

Authors
Lackmann, G., & Töllner, U.
Affiliations
  • Philipps University of Marburg (DE)
  • Klinikum Fulda (DE)
Venue
Neuropediatrics
Publisher
Georg Thieme Verlag KG
Published
1995-08
Volume
26
Issue
04
Pages
192-198
ISSN
  • 0174-304X (ISSN-L)
  • 1439-1899
DOI
10.1055/s-2007-979752
OpenAlex
W1966734965
Cited by
31
References
0
Citations by year
2023: 1 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 4 · 2015: 2 · 2014: 3 · 2013: 1
FWCI
0.84
Type
journal article
Language
en
Open access
closed
Locations
  • Neuropediatrics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal Health and Biochemistry
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Development and Preterm Care
Keywords
hypoxic-ischemic encephalopathy, intraventricular hemorrhage, periventricular hemorrhage, neonatal asphyxia, serum enzyme elevation, lactate dehydrogenase, aspartate aminotransferase, hydroxybutyrate dehydrogenase, predictive biomarkers, term infants, preterm infants, perinatal brain injury
MeSH terms
Hypoxia, Asphyxia Neonatorum, Brain, Cerebral Hemorrhage, Brain Ischemia, Cerebral Ventricles, Humans, Hydroxybutyrate Dehydrogenase, Infant, Newborn, Infant, Premature, Time Factors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review