Echovirus Type 22 Outbreak Associated with Gastro-Intestinal Disease in a Neonatal Intensive Care Unit
Abstract
An echovirus type 22 outbreak involving 19 neonatal intensive care unit (NICU) patients during the months of October and November 1992 is reported. Twelve infants presented with diarrhea, 7 of whom had bloody stools and x-ray findings compatible with early stages of necrotizing enterocolitis, while one infant demonstrated characteristic pneumatosis intestinalis. Outbreaks of echovirus type 22 infection in premature infants have rarely been reported. The possibility of Echovirus 22 infection should be considered in neonatal gastrointestinal disease associated with features of necrotizing enterocolitis.
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Previous reports have shown that EV infections cause relatively stable annual epidemics, while HPeV infections cause sporadic epidemics every few years.
“Previous reports have shown that although EV infections cause relatively stable annual epidemics, HPeV infections cause sporadic epidemics every few years (11–17).”
From Epidemiology of pediatric meningitis and encephalitis in Japan: a cross-sectional study (2024) · cites this paper as [16]
A high frequency of HPeV detection in CSF, particularly during the summer and autumn, has been reported previously.
“A high frequency of HPeV detection in CSF, particularly during the summer and autumn, has also been reported previously (15, 16).”
From Epidemiology of pediatric meningitis and encephalitis in Japan: a cross-sectional study (2024) · cites this paper as [16]
Previous studies have found that almost all children with HPeV infection were young infants, whereas EV infections were widely distributed across most age groups.
“Previous studies have found that almost all children with HPeV infection were young infants, whereas EV infections were widely distributed across most age groups (11–17).”
From Epidemiology of pediatric meningitis and encephalitis in Japan: a cross-sectional study (2024) · cites this paper as [16]
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Epidemiology of pediatric meningitis and encephalitis in Japan: a cross-sectional study
Mizuno, S., Kusama, Y., Otake, S., Ito, Y., Nozaki, M., & Kasai, M. (2024) · Microbiology Spectrum · doi:10.1128/spectrum.01192-24 · Cited by 6 · see citing works
- Authors
- Birenbaum, E., Handsher, R., Kuint, J., Dagan, R., Raichman, B., Mendelson, E., & Linder, N.
- Affiliations
- Tel Aviv University (IL)
- Sheba Medical Center (IL)
- Ben-Gurion University of the Negev (IL)
- ORCID
- Mendelson, Ella
- Venue
- American Journal of Perinatology
- Publisher
- Georg Thieme Verlag KG
- Published
- 1997-09
- Volume
- 14
- Issue
- 08
- Pages
- 469-473
- ISSN
- 0735-1631 (ISSN-L)
- 1098-8785
- OpenAlex
- W1976777584
- Cited by
- 73
- References
- 0
- Citations by year
- 2025: 2 · 2024: 5 · 2023: 1 · 2021: 1 · 2020: 3 · 2019: 1 · 2018: 3 · 2017: 2 · 2016: 4 · 2015: 3 · 2014: 4 · 2013: 6 · 2012: 4
- FWCI
- 0.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Perinatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Neonatal and Maternal Infections
- Keywords
- hospital outbreak, neonatal intensive care unit, necrotizing enterocolitis, neonatal diarrhea, hematochezia, pneumatosis intestinalis, preterm infants, viral infection
- MeSH terms
- Antibodies, Viral, Cross Infection, Disease Outbreaks, Echovirus Infections, Gastrointestinal Diseases, Humans, Infant, Newborn, Intensive Care Units, Neonatal, Israel, Enterovirus B, Human
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