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Cited by 81Respiratory viral infections researchViral Infections and Immunology ResearchLiterature Analysis and Criticism

Epidemiological, Molecular, and Clinical Features of Enterovirus Respiratory Infections in French Children between 1999 and 2005

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Jacques, Jérôme, Moret, Hélène, Minette, Delphine, Lévêque, Nicolas, Jovenin, Nicolas, Deslée, Gaetan, Lebargy, François, Motte, Jacques +1 more·2008·Journal of Clinical Microbiology
DOI 10.1128/jcm.01414-07PMC PMC2224256
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Abstract

Enteroviruses (EVs) can induce nonspecific respiratory tract infections in children, but their epidemiological, virological, and clinical features remain to be assessed. In the present study, we analyzed 252 EV-related infection cases (median age of subjects, 5.1 years) diagnosed among 11,509 consecutive children visiting emergency departments within a 7-year period in the north of France. EV strains were isolated from nasopharyngeal samples by viral cell culture, identified by seroneutralization assay, and genetically compared by partial amplification and sequencing of the VP1 gene. The respiratory syndromes (79 [31%] of 252 EV infections) appeared as the second most common EV-induced pediatric pathology after meningitis (111 [44%] of 252 cases) (44 versus 31%, P < 10 −3 ), contributing to lower respiratory tract infection (LRTI) in 43 (54%) of 79 EV respiratory infection cases. Bronchiolitis was the most common EV-induced LRTI (34 [43%] of 79 cases, P < 10 −3 ) occurring more often in infants aged 1 to 12 months ( P = 0.0002), with spring-fall seasonality. Viruses ECHO 11, 6, and 13 were the more frequently identified respiratory strains (24, 13, and 11%, respectively). The VP1 gene phylogenetic analysis showed the concomitant or successive circulation of genetically distinct EV respiratory strains (species A or B) during the same month or annual epidemic period. Our findings indicated that respiratory tract infections accounted for the 30% of EV-induced pediatric pathologies, contributing to LRTIs in 54% of these cases. Moreover, the concomitant or successive circulation of genetically distinct EV strains indicated the possibility of pediatric repeated respiratory infections within the same epidemic season.

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  • Bacteria adhere to various host cell molecules on the airway epithelium, including PAF-r, P5 fimbriae, CEACAM-1, and ICAM-1.

    “Bacteria adhere to various host cell molecules on the airway epithelium, including platelet-activating factor receptor (PAF-r), outer membrane protein P5-homologous fimbriae (P5 fimbriae), carcinoembryonic antigen-related cellular adhesion 1 (CEACAM-1), and intercellular adhesion molecule 1 (ICAM-1) (37, 124, 251).”

    From The airway epithelium: soldier in the fight against respiratory viruses (2011) · cites this paper as [124]

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  1. [1]Andréoletti, L., M. Lesay, A. Dewilde, V. Lambert, and P. Wattré. 2000. Differential detection of rhinovirus and enterovirus RNA sequences associated with classical immunofluorescence assay detection of respiratory virus antigens in nasopharyngeal swabs from infants with bronchiolitis. J. Med. Virol. 61341-346. [DOI] [PMC free article] [PubMed] [Google Scholar]
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Authors
Jacques, J., Moret, H., Minette, D., Lévêque, N., Jovenin, N., Deslée, G., Lebargy, F., Motte, J., & Andréoletti, L.
Affiliations
  • Laboratoire de Virologie, Centre Hospitalier Universitaire
  • Inserm (FR)
  • Centre Hospitalier Universitaire de Reims (FR)
  • Service de Pneumologie, Centre Hospitalier Universitaire et Faculté de Médecine
ORCID
Jovenin, Nicolas
Venue
Journal of Clinical Microbiology
Publisher
American Society for Microbiology
Published
2008-01
Volume
46
Issue
1
Pages
206-213
ISSN
  • 0095-1137 (ISSN-L)
  • 1098-660X
DOI
10.1128/jcm.01414-07
PMC
PMC2224256
OpenAlex
W2129657736
Cited by
81
References
40
Citations by year
2025: 1 · 2024: 3 · 2023: 2 · 2022: 2 · 2020: 1 · 2019: 6 · 2018: 5 · 2017: 4 · 2016: 6 · 2015: 4 · 2014: 8 · 2013: 7 · 2012: 12
FWCI
3.21
Type
journal article
Language
en
Open access
Licence
journals.asm.org/non-commercial-tdm-license (tdm)
Locations
  • Journal of Clinical Microbiology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Literature Analysis and Criticism
Keywords
enterovirus, respiratory infections, children, bronchiolitis, lower respiratory tract infection, seasonal variation, infants, emergency department visits, seroneutralization
MeSH terms
Adolescent, Age Factors, Bronchiolitis, Child, Child, Preschool, Enterovirus Infections, Enterovirus, Female, France, Humans, Infant, Infant, Newborn, Male, Neutralization Tests, Pharynx, Phylogeny, Respiratory Tract Infections, Seasons, Virus Cultivation, Viral Structural Proteins, Sequence Homology, Amino Acid, Sequence Analysis, DNA

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