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Cited by 260Lipid metabolism and disordersLipoproteins and Cardiovascular HealthCholesterol and Lipid Metabolism

The biochemical, clinical, and genetic features of type III hyperlipoproteinemia.

MORGANROTH, JOEL, LEVY, ROBERT I., FREDRICKSON, DONALD S.·1975·Annals of Internal Medicine
DOI 10.7326/0003-4819-82-2-158
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Abstract

The clinical and biochemical features of type III hyperlipoproteinemia are described in 49 patients from 23 to 70 years of age. An increase in very low-density lipoproteins (VLDL) of abnormal chemical composition was the basis for diagnosis. The untreated patients all had hypercholesterolemia and hyperglyceridemia, and, on the average, decreased concentrations of both low- and high-density lipoproteins. Seventy-four percent had xanthomas, and classic "xanthoma striata palmaris" was found in more than half. Twenty-seven percent had ischemic heart disease, detected earlier in men than in women. Twenty-seven percent had peripheral vascular disease (compared to 4% of subjects with type II hyperlipoproteinemia). Twenty-five of 35 subjects achieved normal lipid levels with dietary therapy alone. Analysis of 29 kindred showed hyperlipidemia in half of adult blood relatives; half of these had type III, the remainder usually had sample endogenous hyperglyceridemia (type IV). Only 2 of 55 children less than 20 years of age were affected, both with type IV.

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Crossref · 10.7326/0003-4819-82-2-158

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  • Thyroid hormone deficiency is associated with increased LDL cholesterol levels, postulated to be due to decreased function of LDL receptors; there can also be an increase in triglyceride levels.

    “Thyroid hormone deficiency is associated with increased LDL cholesterol levels; this increase has been postulated to be due to decreased function of LDL receptors.There can also be an increase in triglyceride levels.Hypo-thyroidism can lead to the expression of dysbetalipoproteinemia (91-93).”

    From Evaluation and Treatment of Hypertriglyceridemia: An Endocrine Society Clinical Practice Guideline (2012) · cites this paper as [91]

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Authors
MORGANROTH, J., LEVY, R. I., & FREDRICKSON, D. S.
Affiliations
Bethesda, Maryland, and Philadelphia, Pennsylvania
Corresponding author
MORGANROTH, JOEL
Venue
Annals of Internal Medicine
Publisher
American College of Physicians
Published
1975-02-01
Volume
82
Issue
2
Pages
158-174
ISSN
  • 0003-4819 (ISSN-L)
  • 1539-3704
DOI
10.7326/0003-4819-82-2-158
OpenAlex
W2072755464
Cited by
260
References
29
Citations by year
2026: 2 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 6 · 2020: 7 · 2019: 3 · 2018: 3 · 2017: 1 · 2016: 3 · 2015: 1 · 2014: 5 · 2013: 2 · 2012: 4
FWCI
13.54
Type
journal article
Language
en
Open access
closed
Licence
www.acpjournals.org/journal/aim/text-and-data-mining (tdm)
Locations
  • Annals of Internal Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
Keywords
type III hyperlipoproteinemia, dyslipidemia, VLDL, hypercholesterolemia, hypertriglyceridemia, xanthoma, ischemic heart disease, peripheral vascular disease, dietary therapy, familial hyperlipidemia, type IV hyperlipoproteinemia, genetic inheritance
MeSH terms
Adult, Age Factors, Aged, Cholesterol, Coronary Disease, Female, Glucose Tolerance Test, Humans, Hypercholesterolemia, Hyperlipidemias, Lipoproteins, Lipoproteins, HDL, Lipoproteins, LDL, Lipoproteins, VLDL, Male, Middle Aged, Triglycerides, Uric Acid, Vascular Diseases, Xanthomatosis

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