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Albumin Synthesis: (First of Two Parts)
Abstract
SERUM albumin is the major protein produced in the liver, comprising as much as 50 per cent of the productive effort at any one moment. The concentration of this protein in the plasma has long been used as a bellwether of health and disease. Yet it must be remembered that the serum albumin level is only the complex end result of synthesis, degradation and distribution. The basic properties of albumin were recognized as early as 1837 by Ancell,1 who noted that "albumen" was needed for transport functions, for maintaining fluidity of the vascular system and for the prevention of edema; . . .
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Cited by
Stehle, G., Sinn, H., Wunder, A., Schrenk, H. H., Stewart, J. C. M., Hartung, G., Maier-Borst, W., & Heene, D. L. (1997) · Critical Reviews in Oncology/Hematology · doi:10.1016/s1040-8428(97)00015-2 · Cited by 305
Protein metabolism in liver cirrhosis: from albumin to muscle myofibrils
Tessari, P. (2003) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/00075197-200301000-00012 · Cited by 93
Predicting the outcome of artificial nutrition by clinical and functional indices
Donini, L. M., Savina, C., Ricciardi, L. M., Coletti, C., Paolini, M., Scavone, L., De Felice, M. R., Laviano, A., Fanelli, F. R., & Cannella, C. (2009) · Nutrition · doi:10.1016/j.nut.2008.07.001 · Cited by 46
PARVING, H.-H., ROSSING, N., & JENSEN, H. A. (1974) · Circulation Research · doi:10.1161/01.res.35.4.544 · Cited by 41
Is it important to correct apparent drug tissue concentrations for blood contamination in the dog?
Giudicelli, C., Dricot, E., Moati, F., Strolin‐Benedetti, M., & Giudicelli, J. (2004) · Fundamental & Clinical Pharmacology · doi:10.1111/j.1472-8206.2004.00246.x · Cited by 11
Metadata
- Authors
- Rothschild, M. A., Oratz, M., & Schreiber, S. S.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1972-04-06
- Volume
- 286
- Issue
- 14
- Pages
- 748-757
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2417016079
- Cited by
- 311
- References
- 0
- FWCI
- 6.64
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Albumin Synthesis: (First of Two Parts). https://app.cochat.ai/papers/10.1056/nejm197204062861404
- The paper
- Rothschild, M. A., Oratz, M., & Schreiber, S. S. (1972). Albumin Synthesis: (First of Two Parts). New England Journal of Medicine. https://doi.org/10.1056/nejm197204062861404
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
