Protein metabolism in liver cirrhosis: from albumin to muscle myofibrils
Abstract
PURPOSE OF REVIEW: Liver cirrhosis in the advanced state is characterized by protein wasting, as indicated by the loss of muscle mass, hypoalbuminemia, and an abnormal amino acid profile. The protein wasting condition cirrhosis is associated with a poor prognosis and reduced survival. Poor nutrition, metabolic and hormonal abnormalities, and other disease-associated alterations may all concur to protein wasting. An understanding of the causes and mechanisms leading to protein wasting in cirrhosis may help in the development of nutritional interventions and new therapies. RECENT FINDINGS: Albumin and muscle protein turnover in cirrhotic patients have been studied in vivo with the aid of isotope dilution techniques or organ catheterization. Albumin synthesis appears to parallel liver function, i.e. the more compromised is the liver, the less is the albumin production rate. Meal-induced albumin synthesis is impaired even in compensated cirrhotic patients. Skeletal muscle protein synthesis is diminished in cirrhosis, and total muscle protein breakdown also appears to be increased, thus explaining the reduced muscle mass. Either hormone or substrate resistance, or newly involved substances (cytokines, insulin-like growth factor 1, leptin) may play a role in the reduced synthesis of both albumin and muscle proteins in liver cirrhosis. SUMMARY: Abnormalities of both albumin and muscle protein turnover have been demonstrated in liver cirrhotic patients. The possible role of the multiple hormonal and metabolic abnormalities of this disease, as well that of cytokines and other recently discovered substances, need to be investigated further.
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Poor nutrition, hormonal and metabolic abnormalities, and inflammatory factors could also contribute to muscle loss in cirrhosis.
“Poor nutrition, hormonal and metabolic abnormalities, and inflammatory factors could also contribute to muscle loss in cirrhosis.113”
From Age-related and disease-related muscle loss: The effect of diabetes, obesity, and other diseases (2014) · cites this paper as [113]
In advanced liver cirrhosis, skeletal muscle protein synthesis is reduced and muscle protein breakdown is increased, leading to reduced muscle mass.
“In patients with advanced liver cirrhosis, skeletal muscle protein synthesis is also reduced, and muscle protein breakdown is increased, leading to reduced muscle mass.”
From Age-related and disease-related muscle loss: The effect of diabetes, obesity, and other diseases (2014) · cites this paper as [113]
Cites
Identification and expression cloning of a leptin receptor, OB-R.
Tartaglia, L. A., Dembski, M., Weng, X., Deng, N., Culpepper, J., Devos, R., Richards, G. J., Campfield, L. A., Clark, F. T., Deeds, J., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90151-5 · Cited by 3,496 · see citing works
Nutrition and survival in patients with liver cirrhosis
Alberino, F., Gatta, A., Amodio, P., Merkel, C., Pascoli, L. D., Boffo, G., & Caregaro, L. (2001) · Nutrition · doi:10.1016/s0899-9007(01)00521-4 · Cited by 513 · see citing works
Galli, A., Crabb, D. W., Ceni, E., Salzano, R., Mello, T., Svegliati–Baroni, G., Ridolfi, F., Trozzi, L., Surrenti, C., & Casini, A. (2002) · Gastroenterology · doi:10.1053/gast.2002.33666 · Cited by 440 · see citing works
Ikejima, K., Takei, Y., Honda, H., Hirose, M., Yoshikawa, M., Zhang, Y., Lang, T., Fukuda, T., Yamashina, S., Kitamura, T., et al. (2002) · Gastroenterology · doi:10.1053/gast.2002.32995 · Cited by 385 · see citing works
Saxena, N. K., Ikeda, K., Rockey, D. C., Friedman, S. L., & Anania, F. A. (2002) · Hepatology · doi:10.1053/jhep.2002.32029 · Cited by 382 · see citing works
Rothschild, M. A., Oratz, M., & Schreiber, S. S. (1972) · New England Journal of Medicine · doi:10.1056/nejm197204062861404 · Cited by 314 · see citing works
Ikejima, K., Honda, H., Yoshikawa, M., Hirose, M., Kitamura, T., Takei, Y., & Sato, N. (2001) · Hepatology · doi:10.1053/jhep.2001.26518 · Cited by 288 · see citing works
Reviews: Role of Albumin in Human Physiology and Pathophysiology
Doweiko, J. P., & Nompleggi, D. J. (1991) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607191015002207 · Cited by 281 · see citing works
The Role of Cytokines in Regulating Protein Metabolism and Muscle Function
Zoico, E., & Roubenoff, R. (2002) · Nutrition Reviews · doi:10.1301/00296640260085949 · Cited by 181 · see citing works
Gender-dependent alterations in serum leptin in alcoholic cirrhosis
McCullough, A. J., Bugianesi, E., Marchesini, G., & Kalhan, S. C. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70267-7 · Cited by 144 · see citing works
Neuman, M. G., Angulo, P., Malkiewicz, I. M., Jorgensen, R. A., Shear, N. H., Dickson, E. R., Haber, J. A., Katz, G. G., & Lindor, K. D. (2002) · Journal of Gastroenterology and Hepatology · doi:10.1046/j.1440-1746.2002.02672.x · Cited by 142 · see citing works
Contribution of Amino Acids and Insulin to Protein Anabolism During Meal Absorption
Volpi, E., Lucidi, P., Cruciani, G., Monacchia, F., Reboldi, G., Brunetti, P., Bolli, G. B., & Feo, P. D. (1996) · Diabetes · doi:10.2337/diab.45.9.1245 · Cited by 129 · see citing works
Feo, P. D., Volpi, E., Lucidi, P., Cruciani, G., Reboldi, G., Siepi, D., Mannarino, E., Santeusanio, F., Brunetti, P., & Bolli, G. B. (1993) · Diabetes · doi:10.2337/diab.42.7.995 · Cited by 111 · see citing works
O’Keefe, S. J., Abraham, R., El‐Zayadi, A., Marshall, W., Davis, M. R., & Williams, R. L. (1981) · Gastroenterology · doi:10.1016/s0016-5085(81)80007-8 · Cited by 106 · see citing works
Skeletal muscle and whole-body protein turnover in cirrhosis
Morrison, W. L., Bouchier, I. A. D., Gibson, J. N. A., & Rennie, M. J. (1990) · Clinical Science · doi:10.1042/cs0780613 · Cited by 105 · see citing works
Rothschild, M. A., Oratz, M., & Schreiber, S. S. (1972) · New England Journal of Medicine · doi:10.1056/nejm197204132861505 · Cited by 103 · see citing works
Lang, C. H., & Frost, R. A. (2002) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/00075197-200205000-00006 · Cited by 99 · see citing works
Immunopathogenesis of hepatitis C viral infection: Th1/Th2 responses and the role of cytokines
Brown, P., & Neuman, M. G. (2001) · Clinical Biochemistry · doi:10.1016/s0009-9120(01)00210-7 · Cited by 90 · see citing works
Ballmer, P. E., Reichen, J., McNurlan, M. A., Sterchi, A., Anderson, S. E., & Garlick, P. J. (1996) · Hepatology · doi:10.1002/hep.510240111 · Cited by 89 · see citing works
Muscle protein breakdown in liver cirrhosis and the role of altered carbohydrate metabolism
Marchesini, G., Zoli, M., Angiolini, A., Dondi, C., Bianchi, F. B., & Pisi, E. (1981) · Hepatology · doi:10.1002/hep.1840010403 · Cited by 81 · see citing works
Albumin synthesis rates in cirrhosis: Correlation with child-turcotte classification
Ballmer, P. E., Walshe, D., McNurlan, M. A., Watson, H., Brunt, P. W., & Garlic, P. J. (1993) · Hepatology · doi:10.1002/hep.1840180211 · Cited by 78 · see citing works
Reduced Serum Somatomedin Activity in Patients with Chronic Liver Disease
Wu, A., Grant, D., Hambley, J., & Levi, A. J. (1974) · Clinical Science · doi:10.1042/cs0470359 · Cited by 74 · see citing works
Pacy, P. J., Preedy, V. R., Peters, T. J., Read, M. A., & HALLIDY, D. (1991) · Alcohol and Alcoholism · doi:10.1093/oxfordjournals.alcalc.a045152 · Cited by 73 · see citing works
Rothschild, M. A., Oratz, M., & Schreiber, S. S. (1973) · Gastroenterology · doi:10.1016/s0016-5085(73)80046-0 · Cited by 70 · see citing works
Neuman, M. G., Benhamou, J. P., Malkiewicz, I. M., Ibrahim, A., Valla, D. C., Martinot-Peignoux, M., Asselah, T., Bourlière, M., Katz, G. G., Shear, N. H., et al. (2002) · Journal of Viral Hepatitis · doi:10.1046/j.1365-2893.2002.00343.x · Cited by 64 · see citing works
Hunter, K. A., Ballmer, P. E., Anderson, S. E., Broom, J. I., Garlick, P. J., & McNurlan, M. A. (1995) · Clinical Science · doi:10.1042/cs0880235 · Cited by 64 · see citing works
Antifibrogenic effect in vivo of low doses of insulin-like growth factor-I in cirrhotic rats
Muguerza, B., Castilla‐Cortázar, I., Garcia‐Fernandez, M. I., Quiroga, J. A., Santidrián, S., & Prìeto, J. (2001) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/s0925-4439(01)00045-x · Cited by 58 · see citing works
Alcoholic myopathy: biochemical mechanisms
Preedy, V. R., Paice, A. G., Mantle, D., Dhillon, A. S., Palmer, T. N., & Peters, T. J. (2001) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(00)00219-2 · Cited by 54 · see citing works
Effect of cirrhosis on energy expenditure
McCullough, A. J., & Raguso, C. A. (1999) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/69.6.1066 · Cited by 51 · see citing works
Insulin-Like Growth Factor 1 and Growth Hormone in Chronic Liver Disease
Møller, S., & Becker, U. (2008) · Digestive Diseases · doi:10.1159/000171362 · Cited by 50 · see citing works
Increase of apamin receptors in skeletal muscle induced by colchicine: possible role in myotonia
Behrens, M. I., & Vergara, C. (1992) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1992.263.4.c794 · Cited by 50 · see citing works
Effect of hyperammonemia on leucine and protein metabolism in rats
Holeček, M., Šprongl, L., & Tichý, M. (2000) · Metabolism · doi:10.1053/meta.2000.9531 · Cited by 47 · see citing works
Effect of insulin and plasma amino acid concentration on leucine metabolism in cirrhosis
Petrides, A. S., Luzi, L., Reuben, A., Riely, C. A., & DeFronzo, R. A. (1991) · Hepatology · doi:10.1002/hep.1840140306 · Cited by 45 · see citing works
Ballmer, P. E., McNurlan, M. A., Grant, I., & Garlick, P. J. (1995) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607195019004266 · Cited by 36 · see citing works
Mechanisms of Alcoholic Liver Disease: Cytokines
Neuman, M. G., Brenner, D. A., Rehermann, B., Taı̈eb, J., Chollet‐Martin, S., Cohard, M., Garaud, J. J., Poynard, T., Katz, G. G., Cameron, R., et al. (2001) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2001.tb02404.x · Cited by 36 · see citing works
Maher, J. J. (1999) · Seminars in Liver Disease · doi:10.1055/s-2007-1007103 · Cited by 34 · see citing works
Worrall, S., Niemelä, O. J., Parkkila, S., Peters, T. J., & Preedy, V. R. (2001) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2001.00848.x · Cited by 33 · see citing works
Blondé-Cynober, F., Aussel, C., & Cynober, L. (1999) · Clinical Nutrition · doi:10.1016/s0261-5614(99)80043-0 · Cited by 33 · see citing works
Ethanol impairs post-prandial hepatic protein metabolism.
Feo, P. D., Volpi, E., Lucidi, P., Cruciani, G., Monacchia, F., Reboldi, G., Santeusanio, F., Bolli, G. B., & Brunetti, P. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117818 · Cited by 32 · see citing works
Tessari, P., Zanetti, M., Barazzoni, R., Biolo, G., Orlando, R., Vettore, M., Inchiostro, S., Perini, P., & Tiengo, A. (1996) · Gastroenterology · doi:10.1053/gast.1996.v111.pm8698191 · Cited by 31 · see citing works
Self-citationModerate and Large Doses of Ethanol Differentially Affect Hepatic Protein Metabolism in Humans ,
Volpi, E., Lucidi, P., Cruciani, G., Monacchia, F., Santoni, S., Reboldi, G., Brunetti, P., Bolli, G. B., & Feo, P. D. (1998) · Journal of Nutrition · doi:10.1093/jn/128.2.198 · Cited by 28 · see citing works
Nutritional and metabolic issues in cirrhosis and liver transplantation
Cabré, E., & Gassull, M. A. (2000) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/00075197-200009000-00004 · Cited by 28 · see citing works
Leucine and phenylalanine kinetics in compensated liver cirrhosis: Effects of insulin
Tessari, P., Biolo, G., Inchiostro, S., Orlando, R., Vettore, M., & Sergi, G. (1993) · Gastroenterology · doi:10.1016/0016-5085(93)90650-2 · Cited by 25 · see citing works
Self-citationContribution of amino acids and insulin to protein anabolism during meal absorption
Volpi, E., Lucidi, P., Cruciani, G., et al. (1996) · Diabetes · doi:10.2337/diabetes.45.9.1245 · Cited by 22 · see citing works
Feo, P. D., Volpi, E., Lucidi, P., et al. (1993) · Diabetes · doi:10.2337/diabetes.42.7.995 · Cited by 22 · see citing works
Recent advances in amino acid transporters and excitatory amino acid receptors
Matthews, J. C., & Anderson, K. J. (2002) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/00075197-200201000-00014 · Cited by 21 · see citing works
Hui, J. M., George, J., Liddle, C., Lin, R., Samarasinghe, D., Crewe, E. B., & Farrell, G. C. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.05621.x · Cited by 19 · see citing works
Depletion of mitochondrial DNA in the skeletal muscle of two cirrhotic patients with severe asthenia
Pesce, V., Cormio, A., Marangi, L. C., Guglielmi, F., Lezza, A. M. S., Francavilla, A., Cantatore, P., & Gadaleta, M. N. (2002) · Gene · doi:10.1016/s0378-1119(01)00815-0 · Cited by 13 · see citing works
The insulin‐like growth factor binding protein 3 ternary complex is reduced in cirrhosis
Ottesen, L. H., Bendtsen, F., & Flyvbjerg, A. (2001) · Liver International · doi:10.1034/j.1600-0676.2001.210508.x · Cited by 12 · see citing works
Protein turnover in abstinent and non-abstinent patients with alcoholic cirrhosis.
Hirsch, S., de la Maza, M. P., Petermann, M., Iturriaga, H., UGARTE, G., & Bunout, D. C. (1995) · Journal of the American College of Nutrition · doi:10.1080/07315724.1995.10718479 · Cited by 9 · see citing works
Effects of wine intake on postprandial plasma amino acid and protein kinetics in type 1 diabetes
Tessari, P., Bruttomesso, D., Pianta, A., Vettore, M., Zanetti, M., Kiwanuka, E., & Iori, E. (2002) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/75.5.856 · Cited by 6 · see citing works
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EASL Clinical Practice Guidelines on nutrition in chronic liver disease
Merli, M., Berzigotti, A., Zelber-Sagi, S., Dasarathy, S., Montagnese, S., Genton, L., Plauth, M., & Parés, A. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2018.06.024 · Cited by 1,130 · see citing works
Age-related and disease-related muscle loss: The effect of diabetes, obesity, and other diseases
Kalyani, R. R., Corriere, M., & Ferrucci, L. (2014) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(14)70034-8 · Cited by 1,102 · see citing works
Quinlan, G. J., Martin, G. S., & Evans, T. W. (2005) · Hepatology · doi:10.1002/hep.20720 · Cited by 985 · see citing works
Rabbani, G., & Ahn, S. N. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.11.053 · Cited by 505 · see citing works
Amodio, P., Bémeur, C., Butterworth, R. F., Córdoba, J., Kato, A., Montagnese, S., Uribe, M., Vilstrup, H., & Morgan, M. Y. (2013) · Hepatology · doi:10.1002/hep.26370 · Cited by 423 · see citing works
Sarcopenia impairs prognosis of patients with liver cirrhosis
Hanai, T., Shiraki, M., Nishimura, K., Ohnishi, S., Imai, K., Suetsugu, A., Takai, K., Shimizu, M., & Moriwaki, H. (2014) · Nutrition · doi:10.1016/j.nut.2014.07.005 · Cited by 390 · see citing works
Lee, Y., Jung, K. S., Kim, S. U., Yoon, H.-J., Yun, Y., Lee, B., Kang, E. S., Han, K., Lee, H. C., & Soo, B. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.02.051 · Cited by 342 · see citing works
Buford, T. W., Anton, S. D., Judge, A. R., Marzetti, E., Wohlgemuth, S. E., Carter, C. S., Leeuwenburgh, C., Pahor, M., & Manini, T. M. (2010) · Ageing Research Reviews · doi:10.1016/j.arr.2010.04.004 · Cited by 295 · see citing works
Periyalwar, P., & Dasarathy, S. (2012) · Clinics in Liver Disease · doi:10.1016/j.cld.2011.12.009 · Cited by 252 · see citing works
Protein energy malnutrition predicts complications in liver cirrhosis
Huisman, E. J., Trip, E. J., Siersema, P. D., van Hoek, B., & van Erpecum, K. J. (2011) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0b013e32834aa4bb · Cited by 218 · see citing works
Kim, G., Lee, S., Lee, Y., Jun, J. E., Ahn, J., Bae, J. C., Jin, S., Hur, K. Y., Jee, J. H., Lee, M., et al. (2018) · Hepatology · doi:10.1002/hep.30049 · Cited by 198 · see citing works
Critical appraisal of the role of serum albumin in cardiovascular disease
Chien, S., Chen, C., Lin, C., & Yeh, H. (2017) · Biomarker Research · doi:10.1186/s40364-017-0111-x · Cited by 185 · see citing works
Qiao, Y.-S., Chai, Y.-H., Gong, H.-J., Zhuldyz, Z., Stehouwer, C. D. A., Zhou, J.-B., & Simó, R. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.782391 · Cited by 132 · see citing works
Elevated Myostatin Levels in Patients with Liver Disease
García, P. S., Cabbabe, A., Kambadur, R., Nicholas, G., & CSETE, M. E. (2010) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e3181eac1c9 · Cited by 107 · see citing works
Dasarathy, S., Dodig, M., Muc, S., Kalhan, S. C., & McCullough, A. J. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00202.2004 · Cited by 107 · see citing works
Posttransplant Sarcopenia: An Underrecognized Early Consequence of Liver Transplantation
Dasarathy, S. (2013) · Digestive Diseases and Sciences · doi:10.1007/s10620-013-2791-x · Cited by 101 · see citing works
Nutrition and exercise in the management of liver cirrhosis
Toshikuni, N. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i23.7286 · Cited by 87 · see citing works
Xiao, J., Caan, B. J., Weltzien, E. K., Feliciano, E. M. C., Kroenke, C. H., Meyerhardt, J. A., Baracos, V. E., Kwan, M. L., Castillo, A., & Prado, C. M. M. (2018) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12301 · Cited by 83 · see citing works
Involvement of Integrins and Src in Insulin Signaling toward Autophagic Proteolysis in Rat Liver
Schliess, F., Reissmann, R., Reinehr, R., Dahl, S. V., & Häussinger, D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313901200 · Cited by 79 · see citing works
Nishikawa, H., Shiraki, M., Hiramatsu, A., Hara, N., Moriya, K., Hino, K., & Koike, K. (2021) · Hepatology Research · doi:10.1111/hepr.13679 · Cited by 77 · see citing works
Albumin synthesis in surgical patients
Hülshoff, A., Schricker, T., Elgendy, H. M., Hatzakorzian, R., & Lattermann, R. (2013) · Nutrition · doi:10.1016/j.nut.2012.10.014 · Cited by 75 · see citing works
Lin, S., Chen, W., Lee, F., Huang, C., & Sheu, W. H. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00186.2004 · Cited by 63 · see citing works
Decoding the Liver-Heart Axis in Cardiometabolic Diseases
Capone, F., Vacca, A., Bidault, G., Sarver, D. C., Kamińska, D., Strocchi, S., Vidal‐Puig, A., Greco, C. M., Lusis, A. J., & Schiattarella, G. G. (2025) · Circulation Research · doi:10.1161/circresaha.125.325492 · Cited by 72 · see citing works
Kawamoto, M. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i27.4325 · Cited by 61 · see citing works
Altered expression of genes regulating skeletal muscle mass in the portacaval anastamosis rat
Dasarathy, S., Muc, S., Hisamuddin, K., Edmison, J. M., Dodig, M., McCullough, A. J., & Kalhan, S. C. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00529.2006 · Cited by 61 · see citing works
Molecular changes in hepatic metabolism and transport in cirrhosis and their functional importance
Dietrich, C. G. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i1.72 · Cited by 50 · see citing works
Morgan, M. Y., Madden, A. M., Jennings, G., Elia, M., & Fuller, N. J. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.5.1151 · Cited by 51 · see citing works
Tejavath, A. S., Mathur, A., Nathiya, D., Singh, P., Raj, P., Suman, S., Mundada, P., Atif, S., Rai, R. R., & Tomar, B. S. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.715795 · Cited by 49 · see citing works
Long-Term Management of Alcoholic Liver Disease
Allampati, S., & Mullen, K. D. (2016) · Clinics in Liver Disease · doi:10.1016/j.cld.2016.02.011 · Cited by 46 · see citing works
Sialadenosis in Patients with Advanced Liver Disease
Guggenheimer, J., Close, J. M., & Eghtesad, B. (2009) · Head and Neck Pathology · doi:10.1007/s12105-009-0113-6 · Cited by 44 · see citing works
Anticatabolic Effects of Avoiding Preoperative Fasting by Intravenous Hypocaloric Nutrition
Schricker, T., Meterissian, S. H., Lattermann, R., Adegoke, O. A. J., Marliss, E. B., Mazza, L., Eberhart, L. H. J., Carli, F., Nitschman, E., & Wykes, L. (2008) · Annals of Surgery · doi:10.1097/sla.0b013e31818842d8 · Cited by 41 · see citing works
Wu, W., Miao, L., Lidong, Z., Zhu, Y., Mao, J., Cai, Z., Ji, Y., Wang, L., Wang, Y., & Jia, T. (2023) · Hematology · doi:10.1080/16078454.2023.2293514 · Cited by 35 · see citing works
Dyspnea and respiratory muscle strength in end-stage liver disease
Kaltsakas, G. (2013) · World Journal of Hepatology · doi:10.4254/wjh.v5.i2.56 · Cited by 35 · see citing works
Mu RF ‐1 and p‐ GSK 3β expression in muscle atrophy of cirrhosis
Merli, M., Giusto, M., Molfino, A., Bonetto, A., Rossi, M., Corradini, S. G., Baccino, F. M., Fanelli, F. R., Costelli, P., & Muscaritoli, M. (2013) · Liver International · doi:10.1111/liv.12128 · Cited by 34 · see citing works
Long-term Management of Alcoholic Liver Disease
Wakim-Fleming, J., & Mullen, K. D. (2005) · Clinics in Liver Disease · doi:10.1016/j.cld.2004.10.001 · Cited by 34 · see citing works
Rojas-Loureiro, G., Servín-Caamaño, A., Pérez-Reyes, E., Servin-Abad, L. A., & la Tijera, F. H.-D. (2017) · World Journal of Hepatology · doi:10.4254/wjh.v9.i5.263 · Cited by 31 · see citing works
Dänicke, S., Kersten, S., Valenta, H., & Breves, G. (2012) · Mycotoxin Research · doi:10.1007/s12550-012-0139-6 · Cited by 32 · see citing works
Kinetics of albumin- and alpha-fetoprotein-production during rat liver development
Elmaouhoub, A., Dudás, J., & Ramadori, G. P. (2007) · Histochemistry and Cell Biology · doi:10.1007/s00418-007-0338-y · Cited by 27 · see citing works
Relationship of liver abnormalities with carcass performance and value*
Grimes, B. B., McEvers, T. J., Tennant, T. C., Johnson, J. W., & Lawrence, T. E. (2024) · Applied Animal Science · doi:10.15232/aas.2023-02482 · Cited by 24 · see citing works
Batista, A. F. R., Petty, D., Fairhurst, C. M., & Davies, S. J. (2022) · Journal of Clinical Anesthesia · doi:10.1016/j.jclinane.2022.110995 · Cited by 25 · see citing works
Hydroxysafflor yellow A suppress oleic acid-induced acute lung injury via protein kinase A
Wang, C., Huang, Q., Wang, C., Zhu, X., Duan, Y., Yuan, S., & Bai, X. (2013) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2013.07.021 · Cited by 24 · see citing works
Dasarathy, S. (2008) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607108324584 · Cited by 23 · see citing works
Predictors of quality of life in patients evaluated for liver transplantation
Jara, M., Bednarsch, J., Malinowski, M. B., Lüttgert, K., Orr, J. G., Puhl, G., Seehofer, D., Neuhaus, P., & Stockmann, M. (2014) · Clinical Transplantation · doi:10.1111/ctr.12426 · Cited by 21 · see citing works
Sörös, P., Böttcher, J., Weißenborn, K., Selberg, O., & Müller, M. J. (2007) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2007.05222.x · Cited by 21 · see citing works
Yang, C., Chen, Q., Zhou, C., Liu, J., Huang, S., Wang, Y., Wang, C., Ju, S., Chen, Y., Li, T., et al. (2022) · American Journal of Roentgenology · doi:10.2214/ajr.21.27301 · Cited by 20 · see citing works
Mahmoudi, A. A., Atkin, S. L., Jamialahmadi, T., Banach, M., & Sahebkar, A. (2022) · Nutrients · doi:10.3390/nu14204344 · Cited by 20 · see citing works
Li, N., Badrinarayanan, A., Li, X., Roberts, J., Hayashi, M., Virk, M., & Gupta, A. (2020) · Drug Metabolism and Disposition · doi:10.1124/dmd.120.000064 · Cited by 20 · see citing works
de Almeida, C. C., Baião, D. D. S., da Silva, D. V. T., da Trindade, L. R., Pereira, P. R., Conte‐Júnior, C. A., & Paschoalin, V. M. F. (2024) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.70053 · Cited by 19 · see citing works
Use of Thrombopoietic Agents for the Thrombocytopenia of Liver Disease
Tillmann, H. L., & McHutchison, J. G. (2010) · Seminars in Hematology · doi:10.1053/j.seminhematol.2010.04.003 · Cited by 18 · see citing works
Impact of recipient functional status on 1-year liver transplant outcomes
Dolgin, N. H., Movahedi, B., Anderson, F. A., Brüggenwirth, I. M. A., Martins, P. N. A., & Bozorgzadeh, A. (2019) · World Journal of Transplantation · doi:10.5500/wjt.v9.i7.145 · Cited by 14 · see citing works
Bekki, T., Abe, T., Amano, H., Hattori, M., Kobayashi, T., Nakahara, M., Ohdan, H., & Noriyuki, T. (2020) · BMC Gastroenterology · doi:10.1186/s12876-020-01472-z · Cited by 14 · see citing works
Évaluation de l’état nutritionnel au cours de la cirrhose
Buyse, S., Durand, F., & Joly, F. (2008) · Gastroentérologie Clinique et Biologique · doi:10.1016/j.gcb.2007.12.023 · Cited by 12 · see citing works
Effects of peritoneal dialysis on protein metabolism
Garibotto, G., Sofia, A., Saffioti, S., Bonanni, A., Mannucci, I., Parodi, E. L., Cademartori, V., & Verzola, D. (2012) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2012.07.005 · Cited by 12 · see citing works
Hipoalbuminemia en el desenlace clínico de pacientes con sangrado de tubo digestivo alto no variceal
González, J. A., Vázquez‐Elizondo, G., Monreal‐Robles, R., García‐Compeán, D., Borjas-Almaguer, O. D., Hernández-Velázquez, B., & Maldonado-Garza, H. J. (2016) · Revista de Gastroenterología de México · doi:10.1016/j.rgmx.2016.03.005 · Cited by 12 · see citing works
Hypoalbuminemia in the outcome of patients with non-variceal upper gastrointestinal bleeding
González, J. A., Vázquez‐Elizondo, G., Monreal‐Robles, R., García‐Compeán, D., Borjas-Almaguer, O. D., Hernández-Velázquez, B., & Maldonado-Garza, H. J. (2016) · Revista de Gastroenterología de México (English Edition) · doi:10.1016/j.rgmxen.2016.08.003 · Cited by 12 · see citing works
Thomason, C. A., Hedrick-Hopper, T. L., & Derting, T. L. (2013) · Canadian Journal of Zoology · doi:10.1139/cjz-2012-0319 · Cited by 12 · see citing works
Lee, D. U., Fan, G. H., Hastie, D. J., Addonizio, E. A., Prakasam, V. N., Ahern, R. R., Suh, J., Seog, K. J., & Karagozian, R. (2021) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2021.1902803 · Cited by 11 · see citing works
Sakata, M., Kawaguchi, T., Taniguchi, E., Nakayama, A., Ishizaki, S., Sonaka, I., Nakamura, T., Itou, M., Oriishi, T., Abe, M., et al. (2010) · e-SPEN the European e-Journal of Clinical Nutrition and Metabolism · doi:10.1016/j.eclnm.2010.09.003 · Cited by 11 · see citing works
Chaganti, J. R., Zeng, G., Tun, N., Lockart, I., Shaheed, C. A., Cysique, L. A., Montagnese, S., Brew, B. J., & Danta, M. (2023) · Hepatology Communications · doi:10.1097/hc9.0000000000000079 · Cited by 10 · see citing works
Yoon, C.-Y., Lee, M., Kim, S. U., Lim, H., Chang, T. I., Kee, Y. K., Han, S. G., Han, I. M., Kwon, Y. E., Park, K. S., et al. (2017) · Kidney Research and Clinical Practice · doi:10.23876/j.krcp.2017.36.1.48 · Cited by 10 · see citing works
Wing, K., Cheung, T. T., She, W. H., Chok, K., Chan, A. C. Y., Dai, W. C., & Lo, C. M. (2017) · Surgical Oncology · doi:10.1016/j.suronc.2017.08.007 · Cited by 10 · see citing works
Nguyen, M., Mukaneza, Y., Tremblay, M., Huard, G., Tang, A., Rose, C. F., & Bémeur, C. (2022) · Canadian Liver Journal · doi:10.3138/canlivj-2021-0042 · Cited by 10 · see citing works
Liu, K., Pan, Y., Wang, X., Ma, T., Li, B., & Chu, J. (2021) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-021-03739-0 · Cited by 9 · see citing works
Muscle circulation contributes to hyperdynamic circulatory syndrome in advanced cirrhosis
Caraceni, P., Dazzani, F., Salizzoni, E., Domenicali, M., Zambruni, A., Trevisani, F., & Bernardi, M. (2008) · Journal of Hepatology · doi:10.1016/j.jhep.2007.12.016 · Cited by 9 · see citing works
Activation of the kynurenine pathway identified in individuals with covert hepatic encephalopathy
Zeng, G., Krishnamurthy, S., Pires, A. S., Guller, A., Chaganti, J. R., Tun, N., Lockart, I., Montagnese, S., Brew, B. J., Guillemin, G. J., et al. (2024) · Hepatology Communications · doi:10.1097/hc9.0000000000000559 · Cited by 8 · see citing works
Magalhães, C., García, J. H. P., Viana, C. F. G., Flor, M. J. N., de Bruin, P. F. C., & Pereira, E. D. B. (2017) · Annals of Hepatology · doi:10.5604/01.3001.0010.7540 · Cited by 8 · see citing works
Thomsen, K. L., Nielsen, S. S., Grønbiek, H., Flyvbjerg, A., & Vilstrup, H. (2008) · PubMed · Cited by 8 · see citing works
Warner, E. R., Aloor, F. Z., & Satapathy, S. K. (2021) · Translational Gastroenterology and Hepatology · doi:10.21037/tgh-20-325 · Cited by 7 · see citing works
Respiratory muscle strength, hypoxemia and dyspnea in liver cirrhosis patients
Abdel-bary, S. A., Yousif, M., & Hussein, H. A. (2014) · Egyptian Journal of Chest Diseases and Tuberculosis · doi:10.1016/j.ejcdt.2014.06.016 · Cited by 7 · see citing works
Li, N., Feng, Y., Chen, X., & Zou, L. (2025) · BMC Cancer · doi:10.1186/s12885-025-14393-5 · Cited by 5 · see citing works
Fernández, M. I. C. (2003) · Cited by 5 · see citing works
A mechanism based approach to management of children with end-stage liver disease
Haafiz, A. (2017) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2017.1367662 · Cited by 5 · see citing works
Hsiao, S.-K., Liang, C., Chang, T.-L., Sung, Y., Chen, Y., Chen, Y., & Wang, J. (2022) · Journal of Materials Chemistry B · doi:10.1039/d1tb02686k · Cited by 5 · see citing works
Sherpa, T. W., Pathak, R., Khadga, P. K., Sharma, S., Hamal, R., & Jha, A. (2019) · Journal of Institute of Medicine Nepal · doi:10.3126/jiom.v41i2.26543 · Cited by 5 · see citing works
Mj, R. (2016) · Journal of Hepatology and Gastrointestinal disorders · doi:10.4172/2475-3181.1000135 · Cited by 4 · see citing works
Ma, K., Zhou, L., & Luo, H. (2026) · Frontiers in Medicine · doi:10.3389/fmed.2025.1696945 · Cited by 3 · see citing works
Khan, M. W. A., Sherwani, S., Alshammari, M. H. E., Alsukaibi, A. K. D., Khan, W. A., Haque, A., Alenezi, K. M., & Shahab, U. (2024) · Pharmaceuticals · doi:10.3390/ph17111469 · Cited by 3 · see citing works
Korolenko, E. A., Korolik, E. V., Korolik, A. K., & Кирковский, В. В. (2007) · Journal of Applied Spectroscopy · doi:10.1007/s10812-007-0088-6 · Cited by 2 · see citing works
Lacaille, F. (2019) · Springer eBooks · doi:10.1007/978-3-319-96400-3_23 · Cited by 2 · see citing works
The Pathogenesis of Physical Frailty and Sarcopenia
Dasarathy, S. (2019) · Springer eBooks · doi:10.1007/978-3-030-26226-6_4 · Cited by 2 · see citing works
Inflammation and Innate Immune Response
(2010) · CRC Press eBooks · doi:10.1201/ebk1439813621-c6 · Cited by 1 · see citing works
Complémentation orale et affections chroniques : insuffisances d'organes, maladies infectieuses
Cano, N. (2005) · Nutrition Clinique et Métabolisme · doi:10.1016/j.nupar.2005.03.001 · Cited by 1 · see citing works
Malnutrition and Nutrition in Liver Disease
Dasarathy, S., & McCullough, A. J. (2009) · Springer eBooks · doi:10.1007/978-3-642-04519-6_37
Protein-Energy Malnutrition in Patients with Liver Cirrhosis
Omagari, K., Kaji, M., Ishii, Y., Iwami, H., Ichimura‐Shimizu, M., Matsutake, S., Kato, S., Takeshita, S., Ichikawa, T., & Nakao, K. (2012) · Nagasaki University's Academic Output SITE (Nagasaki University) · doi:10.11343/amn.57.5
Nutraceuticals in Diabetes Management
Ceballos-Coronel, M. L. (2009) · CRC Press eBooks · doi:10.1201/9781420082227-c12
Dasarathy, S. (2018) · Elsevier eBooks · doi:10.1016/b978-0-323-37591-7.00055-0
Bekki, T., Abe, T., Amano, H., Hattori, M., Kobayashi, T., Nakahara, M., Ohdan, H., & Noriyuki, T. (2020) · Figshare · doi:10.6084/m9.figshare.13065584
Hait, A., Choudhary, A., & Avinash, S. (2025) · International Journal of experimental research and review · doi:10.52756/ijerr.2025.v49.010
- Authors
- Tessari, P.
- Affiliations
- University of Padua (IT)
- Corresponding author
- Tessari, Paolo
- ORCID
- Tessari, Paolo
- Venue
- Current Opinion in Clinical Nutrition and Metabolic Care
- Published
- 2003-01
- Volume
- 6
- Issue
- 1
- Pages
- 79-85
- ISSN
- 1363-1950 (ISSN-L)
- OpenAlex
- W2023650548
- Cited by
- 93
- References
- 49
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4 · 2023: 2 · 2022: 5 · 2021: 8 · 2020: 3 · 2019: 4 · 2018: 5 · 2017: 6 · 2016: 4 · 2015: 2 · 2014: 5 · 2013: 7 · 2012: 5
- FWCI
- 0.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Clinical Nutrition & Metabolic Care (publishedVersion)
- PubMed (publishedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Keywords
- liver cirrhosis, protein wasting, hypoalbuminemia, albumin synthesis, muscle protein turnover, skeletal muscle atrophy, amino acid metabolism, insulin resistance, insulin-like growth factor I, leptin, cytokines, dietary intervention
- MeSH terms
- Albumins, Humans, Insulin-Like Growth Factor I, Liver Cirrhosis, Muscle Proteins, Muscular Atrophy, Myofibrils, Cytokines, Muscle, Skeletal, Leptin
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