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Myocardial Infarction and Estrogen Therapy in Post-Menopausal Women
Abstract
Data obtained from two multipurpose surveys of hospitalized patients were examined to determine the risk of nonfatal acute myocardial infarction in post-menopausal women 40 to 75 years of age in relation to use of estrogen-containing drugs. Eight (2.4 per cent) of 336 myocardial infarction patients and 330 (4.9 per cent) of 6730 reference patients were regular estrogen users (crude rate ratio, 0.47) at the time of hospitalization. After control for confounding variables -- among them, age, past history of myocardial in farction, angina, diabetes, and hypertension (alone or in combination) and cigarette smoking -- the summary point estimate of rate ratio was 0.97 with 95 per cent confidence limits of 0.48 and 1.95. Thus, there was no evidence of a statistically significant association between current regular use of estrogens and nonfatal acute myocardial infarction.
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Citations
Cited by
Estrogen and coronary heart disease in women
Barrett-Connor, E. (1991) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1991.03460140089033 · Cited by 1,241
Wilson, P. W. F., Garrison, R. J., & Castelli, W. P. (1985) · New England Journal of Medicine · doi:10.1056/nejm198510243131702 · Cited by 601
The epidemiology of coronary heart disease and estrogen replacement in postmenopausal women
GRODSTEIN, F., & STAMPFER, M. (1995) · Progress in Cardiovascular Diseases · doi:10.1016/s0033-0620(95)80012-3 · Cited by 417
Combined oral contraceptives: the risk of myocardial infarction and ischemic stroke
Roach, R. E. J., Helmerhorst, F. M., Lijfering, W. M., Stijnen, T., Algra, A., & Dekkers, O. M. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011054.pub2 · Cited by 299
Hormone Therapy in Menopause: Concepts, Controversies, and Approach to Treatment
Flores, V. A., Pal, L., & Manson, J. E. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnab011 · Cited by 174
Metadata
- Authors
- Rosenberg, L., Armstrong, B., & Jick, H.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1976-06-03
- Volume
- 294
- Issue
- 23
- Pages
- 1256-1259
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2043738450
- Cited by
- 168
- References
- 0
- FWCI
- 6.51
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rosenberg, L., Armstrong, B., & Jick, H. (1976). Myocardial Infarction and Estrogen Therapy in Post-Menopausal Women. New England Journal of Medicine. https://doi.org/10.1056/nejm197606032942302
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
