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Cited by 601

The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.

Postmenopausal Estrogen Use, Cigarette Smoking, and Cardiovascular Morbidity in Women over 50: The Framingham Study

Wilson, Peter W.F., Garrison, Robert J., Castelli, William P.·1985·New England Journal of Medicine
DOI 10.1056/nejm198510243131702
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Abstract

We studied the effect of estrogen use on morbidity from cardiovascular disease in 1234 postmenopausal women, aged 50 to 83 years, participating in the Framingham Heart Study's 12th biennial examination (index examination). The medication history recorded at biennial examinations 8 through 12 was used to classify the degree of estrogen exposure before eight years of observation for cardiovascular morbidity and mortality. Despite a favorable cardiovascular risk profile and control for the major known risk factors for heart disease, women reporting postmenopausal estrogen use at one or more examinations had over a 50 per cent elevated risk of cardiovascular morbidity (P less than 0.01) and more than a twofold risk for cerebrovascular disease (P less than 0.01) after the index examination. Increased rates for myocardial infarction (P less than 0.05) were observed particularly among the estrogen users who smoked cigarettes. Conversely, among nonsmokers estrogen use was associated only with an increased incidence of stroke (P less than 0.05). No benefits from estrogen use were observed in the study group; in particular, mortality from all causes and from cardiovascular disease did not differ for estrogen users and nonusers.

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Metadata

Authors
Wilson, P. W. F., Garrison, R. J., & Castelli, W. P.
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
1985-10-24
Volume
313
Issue
17
Pages
1038-1043
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejm198510243131702
OpenAlex
W2341031326
Cited by
601
References
18
FWCI
22.61
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Postmenopausal Estrogen Use, Cigarette Smoking, and Cardiovascular Morbidity in Women over 50: The Framingham Study. https://app.cochat.ai/papers/10.1056/nejm198510243131702
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Wilson, P. W. F., Garrison, R. J., & Castelli, W. P. (1985). Postmenopausal Estrogen Use, Cigarette Smoking, and Cardiovascular Morbidity in Women over 50: The Framingham Study. New England Journal of Medicine. https://doi.org/10.1056/nejm198510243131702

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.