The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Norepinephrine and Epinephrine Release and Adrenergic Mediation of Smoking-Associated Hemodynamic and Metabolic Events
Abstract
We studied the effects of cigarette smoking, sham smoking and smoking during adrenergic blockade in 10 subjects to determine whether smoking released the sympathetic neurotransmitter norepinephrine, as well as the adrenomedullary hormone epinephrine, and whether smoking-associated hemodynamic and metabolic changes were mediated through adrenergic mechanisms. Smoking-associated increments in mean (+/- S.E.M.) plasma norepinephrine (227 +/- 23 to 324 +/- 39 pg per milliliter, P less than 0.01) and epinephrine (44 +/- to 113 +/- 27 pg per milliliter, P less than 0.05) were demonstrated. Smoking-associated increments in pulse rate, blood pressure, blood glycerol and blood lactate/pyruvate ratio were prevented by adrenergic blockade; increments in plasma growth hormone and cortisol were not. Since significant smoking-associated increments, in pulse rate, blood pressure and blood lactate/pyruvate ratio, preceded measurable increments in plasma catecholamine concentrations, but were adrenergically mediated, these changes should be attributed to norepinephrine released locally from adrenergic axon terminals within the tissues rather than to increments in circulating catecholamines.
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“mean plasma epinephrine concentrations rise nearly 2-fold during quiet standing (6), ~3-fold during cigarette smoking (26), from 2–13-fold during mild to heavy exercise (27), and 50fold during insulin-induced hypoglycemia (28).”
From Epinephrine plasma metabolic clearance rates and physiologic thresholds for metabolic and hemodynamic actions in man. (1980) · cites this paper as [26]
Citations
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Cited by
Sorted by citations
Simultaneous single isotope radioenzymatic assay of plasma norepinephrine, epinephrine and dopamine
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Timon, I. M. (2014) · World Journal of Diabetes · doi:10.4239/wjd.v5.i4.444 · Cited by 1,019
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Consequences of smoking for body weight, body fat distribution, and insulin resistance
Chiolero, A., Faeh, D., Paccaud, F., & Cornuz, J. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.4.801 · Cited by 1,192
“Smokers were shown to have higher fasting plasma cortisol concentrations than did nonsmokers (78, 79).”
Background
Metadata
- Authors
- Cryer, P. E., Haymond, M. W., Santiago, J. V., & Shah, S. D.
- Affiliations
- Washington University in St. Louis (US)
- ORCID
- Haymond, Morey W.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1976-09-09
- Volume
- 295
- Issue
- 11
- Pages
- 573-577
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2341712066
- Semantic Scholar
- 61a71636dc3f81cda5208adbb0e928b8f3d3f442
- Cited by
- 1,101
- References
- 29
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 10 · 2023: 14 · 2022: 18 · 2021: 19 · 2020: 22 · 2019: 20 · 2018: 14 · 2017: 22 · 2016: 24 · 2015: 13 · 2014: 23 · 2013: 15 · 2012: 19
- FWCI
- 19.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- cigarette smoking, norepinephrine, epinephrine, sympathetic nervous system, adrenergic blockade, plasma catecholamines, hemodynamic response, blood pressure, pulse rate, blood lactate, growth hormone, cortisol, adrenergic neurotransmission
- MeSH terms
- Adult, Blood Pressure, Epinephrine, Glycerol, Hemodynamics, Humans, Hydrocortisone, Lactates, Male, Norepinephrine, Phentolamine, Propranolol, Pulse, Pyruvates, Smoking, Growth Hormone, Sympathetic Nervous System, Sympatholytics
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