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Cited by 473

The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.

Correlation between Serum IgG-2 Concentrations and the Antibody Response to Bacterial Polysaccharide Antigens

Siber, George R., Schur, Peter H., Aisenberg, Alan C., Weitzman, Sigmund A., Schiffman, Gerald·1980·New England Journal of Medicine
DOI 10.1056/nejm198007243030402
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Abstract

We measured serum concentrations of immunoglobulin classes and IgG subclasses in 53 patients who had completed treatment for Hodgkin's disease and in 10 healthy adults. We wished to determine the relation of these classes and subclasses to the subjects' antibody responses to bacterial polysaccharide and viral protein antigens. Mean levels of the IgG-2 subclass were significantly lower in patients treated with both radiation and chemotherapy than in controls (P less than 0.05). The level of IgG-2 before immunization correlated directly with the mean antibody response both to 11 pneumococcal antigens (r = 0.71, P less than 0.001) and to the Haemophilus influenzae Type b antigen (r = 0.40, P less than 0.01). The correlation between IgG-2 concentration and pneumococcal antibody response was also significant in the 10 healthy adults ( r = 0.70, P less than 0.05). The levels of no immunoglobulin class or subclass correlated significantly with antibody responses to influenza A/Victoria/75 and A/New Jersey/76 hemagglutinins, both of which are protein antigens. The serum concentration of IgG-2 appears to provide a marker for predicting the ability to produce antibodies to polysaccharide, but not viral protein, antigens.

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Metadata

Authors
Siber, G. R., Schur, P. H., Aisenberg, A. C., Weitzman, S. A., & Schiffman, G.
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
1980-07-24
Volume
303
Issue
4
Pages
178-182
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejm198007243030402
OpenAlex
W2326707926
Cited by
473
References
10
FWCI
5.21
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Correlation between Serum IgG-2 Concentrations and the Antibody Response to Bacterial Polysaccharide Antigens. https://app.cochat.ai/papers/10.1056/nejm198007243030402
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Siber, G. R., Schur, P. H., Aisenberg, A. C., Weitzman, S. A., & Schiffman, G. (1980). Correlation between Serum IgG-2 Concentrations and the Antibody Response to Bacterial Polysaccharide Antigens. New England Journal of Medicine. https://doi.org/10.1056/nejm198007243030402

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.