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Hepatic Vitamin A Depletion in Alcoholic Liver Injury
Abstract
SYMPTOMS of vitamin A deficiency, such as night blindness and hypogonadism, have been described in alcoholics,1 , 2 but the relation between alcoholism, serum vitamin A, and hepatic vitamin A is not known.Previous studies of hepatic vitamin A levels in various disease states involved only autopsy material, did not include biopsy data, and did not specify whether the subjects studied were alcoholic.3 4 5 There are some reports on patients with alcoholic cirrhosis who had evidence of a low circulating level of vitamin A,2 , 6 7 8 but the actual hepatic vitamin A concentrations of these subjects have not been described. Therefore, we undertook a study . . .
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Citations
Cited by
Vitamin A metabolism: An update
D’Ambrosio, D. N., Clugston, R. D., & Blaner, W. S. (2011) · Nutrients · doi:10.3390/nu3010063 · Cited by 562
Hepatic stellate cell lipid droplets: A specialized lipid droplet for retinoid storage
Blaner, W. S., O'Byrne, S. M., Wongsiriroj, N., Kluwe, J., D'Ambrosio, D. M., Jiang, H., Schwabe, R. F., Hillman, E. M. C., Piantedosi, R., & Libien, J. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2008.11.001 · Cited by 444
Retinoic acid receptors: From molecular mechanisms to cancer therapy
di Masi, A., Leboffe, L., De Marinis, E., Pagano, F., Cicconi, L., Rochette-Egly, C., Lo-Coco, F., Ascenzi, P., & Nervi, C. (2015) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2014.12.003 · Cited by 403
Lieber, C. S. (2005) · Clinics in Liver Disease · doi:10.1016/j.cld.2004.10.005 · Cited by 274
Self-citationHepatic metabolism of retinoids and disease associations
Shirakami, Y., Lee, S.-A., Clugston, R. D., & Blaner, W. S. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.06.023 · Cited by 203
Metadata
- Authors
- Leo, M. A., & Lieber, C. S.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1982-09-02
- Volume
- 307
- Issue
- 10
- Pages
- 597-601
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2064526327
- Cited by
- 341
- References
- 0
- FWCI
- 9.26
- Type
- journal article
- Language
- en
- Open access
- closed
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- Leo, M. A., & Lieber, C. S. (1982). Hepatic Vitamin A Depletion in Alcoholic Liver Injury. New England Journal of Medicine. https://doi.org/10.1056/nejm198209023071006
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
