The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
The Prevalence of Bone Aluminum Deposition in Renal Osteodystrophy and Its Relation to the Response to Calcitriol Therapy
Abstract
A histochemical stain for bone aluminum allowed us to determine the prevalence and staining characteristics of aluminum in renal osteodystrophy. The staining method correlated well with the results of atomic-absorption studies in 96 samples (r = 0.81; P less than 0.001). We examined 315 bone-biopsy samples. No aluminum was seen in controls or patients with nonrenal bone disease. In renal osteodystrophy, the mean level of stainable aluminum was significantly higher in osteomalacic lesions (1.12 +/- 0.09 mm per square millimeter of tissue area) than in mild, mixed, of fibrotic lesions (0.43 +/- 0.06, 0.34 +/- 0.11, and 0.10 +/- 0.03 mm per square millimeter, respectively; P less than 0.001). Seventy per cent of osteomalacic samples had heavy aluminum staining. The bone-apposition rate, measured by double tetracycline labels, was low in 89 per cent of the samples with high levels of aluminum. The mean level of stainable bone aluminum in patients who had a clinical response to calcitriol was significantly lower than in those who did not respond (0.13 +/- 0.4 vs. 1.06 +/- 0.9 mm per square millimeter; P less than 0.01). We conclude that aluminum deposition is associated with impaired bone formation or mineralization and with a poor response to calcitriol therapy.
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Citations
Cites
Applied Regression Analysis and Other Multivariable Methods
Walker, E. (1989) · Technometrics · doi:10.1080/00401706.1989.10488486 · Cited by 8,538
The Dialysis Encephalopathy Syndrome: Possible Aluminum Intoxication
Alfrey, A. C., LeGendre, G. R., & Kaehny, W. D. (1976) · New England Journal of Medicine · doi:10.1056/nejm197601222940402 · Cited by 1,621
Self-citationApplied regression analysis and other multivariable methods
Kleinbaum, D. G. (1998) · Cited by 928
Gastrointestinal Absorption of Aluminum from Aluminum-Containing Antacids
Kaehny, W. D., Hegg, A. P., & Alfrey, A. C. (1977) · New England Journal of Medicine · doi:10.1056/nejm197706162962407 · Cited by 398
Self-citationFRACTURING DIALYSIS OSTEODYSTROPHY AND DIALYSIS ENCEPHALOPATHY
Parkinson, I. S., Feest, T. G., Kerr, D. N. S., Ward, M. K., & Fawcett, R. W. P. (1979) · The Lancet · doi:10.1016/s0140-6736(79)90883-3 · Cited by 373
Bone Aluminum and Histomorphometric Features of Renal Osteodystrophy*
HODSMAN, A. B., SHERRARD, D. J., ALFREY, A. C., OTT, S., BRICKMAN, A. S., MILLER, N. L., MALONEY, N. A., & COBURN, J. W. (1982) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-54-3-539 · Cited by 272
Self-citationAluminum localization in bone from hemodialyzed patients: Relationship to matrix mineralization
Cournot-Witmer, G., Zingraff, J., Plachot, J. J., Escaig, F., Lefèvre, R., Boumati, P., Bourdeau, A., Garabédian, M., Galle, P., Bourdon, R., et al. (1981) · Kidney International · doi:10.1038/ki.1981.149 · Cited by 271
Ellis, H. A., McCarthy, J. H., & Herrington, J. (1979) · Journal of Clinical Pathology · doi:10.1136/jcp.32.8.832 · Cited by 266
Histological quantitation of aluminum in iliac bone from patients with renal failure.
Maloney, N. A., Ott, S. M., Alfrey, A. C., Miller, N. L., Coburn, J. W., & Sherrard, D. J. (1982) · PubMed · Cited by 250
Self-citationSUCCESSFUL REMOVAL OF ALUMINIUM FROM PATIENT WITH DIALYSIS ENCEPHALOPATHY
Ackrill, P., Ralston, A. J., Day, J. P., & Hodge, K. C. (1980) · The Lancet · doi:10.1016/s0140-6736(80)92728-2 · Cited by 216
Cited by
Human Health Risk Assessment for Aluminium, Aluminium Oxide, and Aluminium Hydroxide
Krewski, D., Yokel, R. A., Nieboer, E., Borchelt, D., Cohen, J., Harry, J., Kacew, S., Lindsay, J., Mahfouz, A. M., & Rondeau, V. (2007) · Journal of Toxicology and Environmental Health, Part B · doi:10.1080/10937400701597766 · Cited by 998
The spectrum of bone disease in end-stage renal failure—An evolving disorder
Sherrard, D. J., Hercz, G., Pei, Y., Maloney, N. A., Greenwood, C., Manuel, A., Saiphoo, C., Fenton, S. S., & Segre, G. V. (1993) · Kidney International · doi:10.1038/ki.1993.64 · Cited by 730
Self-citationSlatopolsky, E. A., Burke, S. K., & Dillon, M. A. (1999) · Kidney International · doi:10.1046/j.1523-1755.1999.00240.x · Cited by 302
Aplastic osteodystrophy without aluminum: The role of “suppressed” parathyroid function
Hercz, G., Pei, Y., Greenwood, C., Manuel, A., Saiphoo, C., Goodman, W. G., Segre, G. V., Fenton, S., & Sherrard, D. J. (1993) · Kidney International · doi:10.1038/ki.1993.323 · Cited by 281
Self-citationMalluche, H. H., Smith, A. J., Abreo, K., & Faugere, M.-C. (1984) · New England Journal of Medicine · doi:10.1056/nejm198407193110302 · Cited by 199
Metadata
- Authors
- Ott, S. M., Maloney, N. A., Coburn, J. W., Alfrey, A. C., & Sherrard, D. J.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1982-09-16
- Volume
- 307
- Issue
- 12
- Pages
- 709-713
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2334976439
- Cited by
- 353
- References
- 18
- FWCI
- 29.15
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The Prevalence of Bone Aluminum Deposition in Renal Osteodystrophy and Its Relation to the Response to Calcitriol Therapy. https://app.cochat.ai/papers/10.1056/nejm198209163071202
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- Ott, S. M., Maloney, N. A., Coburn, J. W., Alfrey, A. C., & Sherrard, D. J. (1982). The Prevalence of Bone Aluminum Deposition in Renal Osteodystrophy and Its Relation to the Response to Calcitriol Therapy. New England Journal of Medicine. https://doi.org/10.1056/nejm198209163071202
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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