The DOI matches its Crossref record.
Hepatitis B Vaccine in Medical Staff of Hemodialysis Units: Efficacy and Subtype Cross-Protection
Abstract
We evaluated the efficacy of hepatitis B vaccine (Heptavax-B) containing only the ad subtype in a randomized, placebo-controlled, double-blind trial among 865 staff members of 43 hemodialysis units in the United States. Surface antibody developed in 92.6 per cent of the subjects after two doses of vaccine and in 96 per cent after the six-month booster. The incidence of infections with hepatitis B virus (with or without hepatitis) was 9.9 per cent in placebo recipients and 2.2 per cent in vaccine recipients (P less than 0.01). The two cases of hepatitis B among vaccine recipients did not occur in subjects in whom antibody had developed. In 81 per cent of the hepatitis events, the virus was of the ay subtype. The indicence of ay virus was 8.2 per cent among placebo recipients and 1.2 per cent among vaccine recipients (P less than 0.005). We conclude that these data confirm the efficacy of the vaccine and demonstrate subtype cross-protection.
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Citations
Cited by
An Assay for Circulating Antibodies to a Major Etiologic Virus of Human Non-A, Non-B Hepatitis
Kuo, G., Choo, Q.-L., Alter, H. J., Gitnick, G. L., Redeker, A. G., Purcell, R. H., Miyamura, T., Dienstag, J. L., Alter, M. J., Stevens, C. E., et al. (1989) · Science · doi:10.1126/science.2496467 · Cited by 3,346
Self-citationTiollais, P., Pourcel, C., & Dejean, A. (1985) · Nature · doi:10.1038/317489a0 · Cited by 1,205
Long-Term Immunogenicity and Efficacy of Hepatitis B Vaccine in Homosexual Men
Hadler, S. C., Francis, D. P., Maynard, J. E., Thompson, S. E., Judson, F. N., Echenberg, D. F., Ostrow, D. G., O'Malley, P. M., Penley, K. A., Altman, N. L., et al. (1986) · New England Journal of Medicine · doi:10.1056/nejm198607243150401 · Cited by 608
Obesity as a Predictor of Poor Antibody Response to Hepatitis B Plasma Vaccine
Weber, D. J. (1985) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1985.03360220053027 · Cited by 345
Hepatitis B vaccination: The key towards elimination and eradication of hepatitis B
Chen, D.-S. (2009) · Journal of Hepatology · doi:10.1016/j.jhep.2009.01.002 · Cited by 261
Metadata
- Authors
- Szmuness, W., Stevens, C. E., Harley, E. J., Zang, E. A., Alter, H. J., Taylor, P. E., DE Vera, A., Chen, G. T. S., Kellner, A., & the Dialysis Vaccine Trial Study Group
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1982-12-09
- Volume
- 307
- Issue
- 24
- Pages
- 1481-1486
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2320034768
- Cited by
- 262
- References
- 0
- FWCI
- 21.24
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Hepatitis B Vaccine in Medical Staff of Hemodialysis Units: Efficacy and Subtype Cross-Protection. https://app.cochat.ai/papers/10.1056/nejm198212093072403
- The paper
- Szmuness, W., Stevens, C. E., Harley, E. J., Zang, E. A., Alter, H. J., Taylor, P. E., DE Vera, A., Chen, G. T. S., Kellner, A., & the Dialysis Vaccine Trial Study Group. (1982). Hepatitis B Vaccine in Medical Staff of Hemodialysis Units: Efficacy and Subtype Cross-Protection. New England Journal of Medicine. https://doi.org/10.1056/nejm198212093072403
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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