The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Sensory Neuropathy from Pyridoxine Abuse: A New Megavitamin Syndrome
Abstract
We describe seven adults who had ataxia and severe sensory-nervous-system dysfunction after daily high-level pyridoxine (vitamin B6) consumption. Four were severely disabled; all improved after withdrawal. Weakness was not a feature of this condition, and the central nervous system was clinically spared. Although consumption of large doses of pyridoxine has gained wide public acceptance, this report indicates that it can cause sensory neuropathy or neuronopathy syndromes and that safe guidelines should be established for the use of this widely abused vitamin.
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Citations
Cites
Pauling, L. (1968) · Science · doi:10.1126/science.160.3825.265 · Cited by 304
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(1972) · Annals of Internal Medicine · doi:10.7326/0003-4819-76-2-352_9 · Cited by 216
Goldsmith, G. A. (1964) · Medical Clinics of North America · doi:10.1016/s0025-7125(16)33389-2 · Cited by 198
The effect of high doses of vitamin B6 on autistic children: a double- blind crossover study
(1978) · American Journal of Psychiatry · doi:10.1176/ajp.135.4.472 · Cited by 159
Treatment of acute isoniazid toxicity
Sievers, M. L., & Herrier, R. N. (1975) · American Journal of Health-System Pharmacy · doi:10.1093/ajhp/32.2.202 · Cited by 60
Subacute toxicity of pyridoxine hydrochloride in the beagle dog
Phillips, W. E. J., Mills, J. H. L., Charbonneau, S. M., Tryphonas, L., Hatina, G. V., Zawidzka, Z., Bryce, F., & Munro, I. C. (1978) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(78)90194-1 · Cited by 54
VITAMIN B6 TRANSPORT IN THE CENTRAL NERVOUS SYSTEM: IN VITRO STUDIES
Spector, R. (1978) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1978.tb10798.x · Cited by 54
Convulsions as the etiology of lactic acidosis in acute isoniazid toxicity in dogs
Chin, L., Sievers, M. L., Herrier, R. N., & Picchioni, A. L. (1979) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(79)90263-1 · Cited by 50
Evaluation of diazepam and pyridoxine as antidotes to isoniazid intoxication in rats and dogs
Chin, L., Sievers, M. L., Laird, H. E., Herrier, R. N., & Picchioni, A. L. (1978) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(78)90164-3 · Cited by 50
Megavitamins for Minimal Brain Dysfunction
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Cited by
Vitamin B6 and Its Role in Cell Metabolism and Physiology
Parra, M., Stahl, S., & Hellmann, H. (2018) · Cells · doi:10.3390/cells7070084 · Cited by 532
Greene, H., Hambidge, K., Schanler, R., & Tsang, R. (1988) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/48.5.1324 · Cited by 391
Nutrient Requirements For Preterm Infant Formulas
Klein, C. J. (2002) · The Journal of Nutrition · doi:10.1093/jn/132.6.1395s · Cited by 383
Guidelines for the diagnosis and management of cystathionine beta‐synthase deficiency
Morris, A. A. M., Kožich, V., Santra, S., Andria, G., Ben‐Omran, T. I. M., Chakrapani, A. B., Crushell, E., Henderson, M. J., Hochuli, M., Huemer, M., et al. (2017) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-016-9979-0 · Cited by 340
The diagnostic yield of a standardized approach to idiopathic sensory-predominant neuropathy
Smith, A. G., & Singleton, J. R. (2004) · Archives of Internal Medicine · doi:10.1001/archinte.164.9.1021 · Cited by 95
Metadata
- Authors
- Schaumburg, H., Kaplan, J., Windebank, A., Vick, N., Rasmus, S., Pleasure, D., & Brown, M. J.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1983-08-25
- Volume
- 309
- Issue
- 8
- Pages
- 445-448
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2017861431
- Cited by
- 708
- References
- 12
- FWCI
- 34.53
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Sensory Neuropathy from Pyridoxine Abuse: A New Megavitamin Syndrome. https://app.cochat.ai/papers/10.1056/nejm198308253090801
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- Schaumburg, H., Kaplan, J., Windebank, A., Vick, N., Rasmus, S., Pleasure, D., & Brown, M. J. (1983). Sensory Neuropathy from Pyridoxine Abuse: A New Megavitamin Syndrome. New England Journal of Medicine. https://doi.org/10.1056/nejm198308253090801
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
