Cited by 872Statistical Methods in Clinical TrialsMeta-analysis and systematic reviewsAdvanced Causal Inference Techniques

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Bias in Treatment Assignment in Controlled Clinical Trials

Chalmers, Thomas C., Celano, Paul, Sacks, Henry S., Smith, Harry·1983·New England Journal of Medicine

DOI 10.1056/nejm198312013092204

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Abstract

Controlled clinical trials of the treatment of acute myocardial infarction offer a unique opportunity for the study of the potential influence on outcome of bias in treatment assignment. A group of 145 papers was divided into those in which the randomization process was blinded (57 papers), those in which it may have been unblinded (45 papers), and those in which the controls were selected by a nonrandom process (43 papers). At least one prognostic variable was maldistributed (P less than 0.05) in 14.0 per cent of the blinded-randomization studies, in 26.7 per cent of the unblinded-randomization studies, and in 58.1 per cent of the nonrandomized studies. Differences in case-fatality rates between treatment and control groups (P less than 0.05) were found in 8.8 per cent of the blinded-randomization studies, 24.4 per cent of the unblinded-randomization studies, and 58.1 per cent of the nonrandomized studies. These data emphasize the importance of keeping those who recruit patients for clinical trials from suspecting which treatment will be assigned to the patient under consideration.

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Freiman, J. A., Chalmers, T. C., Smith, H., & Kuebler, R. R. (1978) · New England Journal of Medicine · doi:10.1056/nejm197809282991304 · Cited by 1,628
Self-citation
A New Design for Randomized Clinical Trials
Zelen, M. (1979) · New England Journal of Medicine · doi:10.1056/nejm197905313002203 · Cited by 1,057
Randomized versus historical controls for clinical trials
Sacks, H., Chalmers, T. C., & Smith, H. (1982) · The American Journal of Medicine · doi:10.1016/0002-9343(82)90815-4 · Cited by 834
Self-citation
Association of Adrenocorticosteroid Therapy and Peptic-Ulcer Disease
Messer, J., Reitman, D., Sacks, H. S., Smith, H., & Chalmers, T. C. (1983) · New England Journal of Medicine · doi:10.1056/nejm198307073090105 · Cited by 420
Self-citation
A show of confidence.
Rothman, K. J. (1978) · New England Journal of Medicine · doi:10.1056/nejm197812142992410 · Cited by 281
Non-Randomized Controls in Cancer Clinical Trials
Gehan, E. A., & Freireich, E. J. (1974) · New England Journal of Medicine · doi:10.1056/nejm197401242900405 · Cited by 276
Allocation of Subjects in Medical Experiments
Weinstein, M. C. (1974) · New England Journal of Medicine · doi:10.1056/nejm197412122912405 · Cited by 189
Are Randomized Trials Appropriate for Evaluating New Operations?
Bonchek, L. I. (1979) · New England Journal of Medicine · doi:10.1056/nejm197907053010110 · Cited by 103
The Role of the Randomized Clinical Trial in the Evaluation of New Operations
Bonchek, L. I. (1982) · Surgical Clinics of North America · doi:10.1016/s0039-6109(16)42793-3 · Cited by 29
Randomized clinical trials in surgery.
Folland, E. D., Hammermeister, K. E., Khuri, S. F., Rahimtoola, S. H., Sethi, G. K., & Souchek, J. (1979) · PubMed · Cited by 22

Show all 13 references

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Wilby, J., Kainth, A., Hawkins, N., Epstein, D. M., McIntosh, H., McDaid, C., Mason, A., Golder, S., O’Meara, S., Sculpher, M. J., et al. (2005) · Health Technology Assessment · doi:10.3310/hta9150 · Cited by 271
Systematic reviews and meta-analysis of preclinical studies: why perform them and how to appraise them critically
Sena, E. S., Currie, G. L., McCann, S. K., Macleod, M. R., & Howells, D. W. (2014) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2014.28 · Cited by 264
Screening for lung cancer
Manser, R. L., Lethaby, A. E., Irving, L. B., Stone, C., Byrnes, G. B., Abramson, M. J., & Campbell, D. A. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001991.pub3 · Cited by 262
Preoperative Autologous Donation Decreases Allogeneic Transfusion but Increases Exposure to All Red Blood Cell Transfusion Results of a Meta-analysis
Forgie, M. A. (1998) · Archives of Internal Medicine · doi:10.1001/archinte.158.6.610 · Cited by 262
Back schools for non-specific low-back pain.
Heymans, M. W., van Tulder, M. W., Esmail, R., Bombardier, C., & Koes, B. W. (2004) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000261.pub2 · Cited by 260
Principles of and Procedures for Systematic Reviews
Egger, M., & Smith, G. D. (2001) · Wiley eBooks · doi:10.1002/9780470693926.ch2 · Cited by 255
Antiplatelets Versus Anticoagulation in Cervical Artery Dissection
Engelter, S. T., Brandt, T., Debette, S., Caso, V., Lichy, C., Pezzini, A., Abboud, S., Bersano, A., Dittrich, R., Grond‐Ginsbach, C., et al. (2007) · Stroke · doi:10.1161/strokeaha.107.489666 · Cited by 248
Meta‐analysis of clinical trials as a scientific discipline. I: Control of bias and comparison with large co‐operative trials
Chalmers, T. C., Levin, H. R., Sacks, H. S., Reitman, D., Berrier, J., & Nagalingam, R. (1987) · Statistics in Medicine · doi:10.1002/sim.4780060320 · Cited by 250
Self-citation
High frequency oscillation in patients with acute lung injury and acute respiratory distress syndrome (ARDS): systematic review and meta-analysis
Sud, S., Sud, M. K., Friedrich, J. O., Meade, M., Ferguson, N. D., Wunsch, H., & Adhikari, N. K. J. (2010) · BMJ · doi:10.1136/bmj.c2327 · Cited by 245
Folic acid with or without vitamin B12 for cognition and dementia
Malouf, R. S., Evans, J. G., & Sastre, A. A. (2003) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004514 · Cited by 243

Authors: Chalmers, T. C., Celano, P., Sacks, H. S., & Smith, H.
Affiliations: Mount Sinai Hospital (US)
ORCID: Celano, Paul
Sacks, Henry S.
Smith, Harry
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 1983-12
Volume: 309
Issue: 22
Pages: 1358-1361
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejm198312013092204
OpenAlex: W2030192997
Cited by: 864
References: 13
Citations by year: 2026: 1 · 2025: 3 · 2024: 8 · 2023: 6 · 2022: 10 · 2021: 9 · 2020: 8 · 2019: 14 · 2018: 7 · 2017: 18 · 2016: 15 · 2015: 19 · 2014: 15 · 2013: 18 · 2012: 19
FWCI: 13.03
Type: journal article
Language: en
Open access: closed
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
DigitalGeorgetown (Georgetown University Library) (submittedVersion)
Topics: Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Clinical Trials
Social Sciences › Decision Sciences › Statistics, Probability and Uncertainty › Meta-analysis and systematic reviews
Physical Sciences › Mathematics › Statistics and Probability › Advanced Causal Inference Techniques
Keywords: unblinding, acute myocardial infarction, case fatality, control selection, clinical trial design
MeSH terms: Clinical Trials as Topic, Ethics, Medical, Humans, Myocardial Infarction, Outcome and Process Assessment, Health Care, Prognosis, Random Allocation, Research Design, Risk

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Bias in Treatment Assignment in Controlled Clinical Trials

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