The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
The Corticotropin-Releasing Factor Stimulation Test: An Aid in the Evaluation of Patients with Cushing's Syndrome
Abstract
We investigated the effect of exogenous corticotropin-releasing factor on plasma levels of ACTH and cortisol in 13 patients with ACTH-secreting pituitary adenomas (Cushing's disease) and in 9 patients with other forms of Cushing's syndrome. In all patients with Cushing's disease, ovine corticotropin-releasing factor, given intravenously as a bolus injection (1 microgram per kilogram of body weight), caused a further increase in the already elevated levels of ACTH and cortisol. Successful transphenoidal adenomectomy was followed as early as one week after surgery by normalization or near-normalization of the ACTH and cortisol responses to corticotropin-releasing factor. On the other hand, patients with the ectopic ACTH syndrome, who also had high basal plasma concentrations of ACTH and cortisol, had no ACTH or cortisol responses to corticotropin-releasing factor. This difference in responsiveness between these two patient groups cannot be explained on the basis of different metabolic clearance rates of exogenous corticotropin-releasing factor, as shown by similar disappearance curves of immunoreactive corticotropin-releasing factor from plasma. Patients with Cushing's syndrome of adrenal origin who were hypercortisolemic during testing had undetectable plasma levels of ACTH and no ACTH or cortisol responses to corticotropin-releasing factor. We conclude that stimulation of the pituitary-adrenal axis with corticotropin-releasing factor may be useful in differentiating pituitary from ectopic causes of Cushing's syndrome.
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Cites
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Cited by
Sternberg, E. M., Hill, J. M., Chrousos, G. P., Kamilaris, T., Listwak, S. J., Gold, P. W., & Wilder, R. L. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.7.2374 · Cited by 723
Self-citationHuman Leptin Levels Are Pulsatile and Inversely Related to Pituitary–Ardenal Function
Licinio, J., Mantzoros, C., Negrão, A. B., Cizza, G., Wong, M.-L., Bongiorno, P. B., Chrousos, G. P., Karp, B., Allen, C., Flier, J. S., et al. (1997) · Nature Medicine · doi:10.1038/nm0597-575 · Cited by 632
Self-citationAcute Hypothalamic–Pituitary–Adrenal Responses to the Stress of Treadmill Exercise
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Self-citationCushing's syndrome in children and adolescents. Presentation, diagnosis, and therapy.
Magiakou, M. A., Mastorakos, G., Oldfield, E. H., Gomez, M. T., Doppman, J. L., Cutler, G. B., Nieman, L. K., & Chrousos, G. P. (1994) · New England Journal of Medicine · doi:10.1056/nejm199409083311002 · Cited by 430
Self-citationChronic insomnia and activity of the stress system
Vgontzas, A. N., Tsigos, C., Bixler, E. O., Stratakis, C. A., Zachman, K., Kales, A., Vela-Bueno, A., & Chrousos, G. P. (1998) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(97)00302-4 · Cited by 401
Self-citation
Metadata
- Authors
- Chrousos, G. P., Schulte, H. M., Oldfield, E. H., Gold, P. W., Cutler, G. B., & Loriaux, D. L.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1984-03-08
- Volume
- 310
- Issue
- 10
- Pages
- 622-626
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2798061778
- Cited by
- 348
- References
- 25
- FWCI
- 31.73
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The Corticotropin-Releasing Factor Stimulation Test: An Aid in the Evaluation of Patients with Cushing's Syndrome. https://app.cochat.ai/papers/10.1056/nejm198403083101004
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- Chrousos, G. P., Schulte, H. M., Oldfield, E. H., Gold, P. W., Cutler, G. B., & Loriaux, D. L. (1984). The Corticotropin-Releasing Factor Stimulation Test: An Aid in the Evaluation of Patients with Cushing's Syndrome. New England Journal of Medicine. https://doi.org/10.1056/nejm198403083101004
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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