Some Speculations about Prions, Amyloid, and Alzheimer's Disease
Abstract
The causes of most degenerative diseases are unknown; however, the causes of three degenerative disorders of the central nervous system have been defined by their transmissibility to animals. These diseases are kuru, Creutzfeldt–Jakob disease, and the Gerstmann-Straüssler syndrome.1 , 2 The slow infectious agents that cause these diseases appear to be different from viruses but similar to the agent that causes scrapie, a neurologic disorder of sheep and goats.1 , 3 The term "prion" has been introduced to denote this slow infectious agent, with its unusual properties.3 Studies of the molecular structure of scrapie prions in highly purified preparations indicate that they contain one . . .
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Pathologic similarities with prion disease suggest that the formation and spread of proteinaceous lesions might involve a common molecular mechanism, corruptive protein templating.
“Pathologic similarities with prion disease suggest that the formation and spread of these proteinaceous lesions might involve a common molecular mechanism – corruptive protein templating.”
From Pathogenic protein seeding in Alzheimer disease and other neurodegenerative disorders (2011) · cites this paper as [2]
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- Authors
- Prusiner, S. B.
- Corresponding author
- Prusiner, Stanley B.
- ORCID
- Prusiner, Stanley B.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1984-03-08
- Volume
- 310
- Issue
- 10
- Pages
- 661-663
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2014908349
- Cited by
- 213
- References
- 19
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 9 · 2023: 5 · 2022: 1 · 2021: 10 · 2020: 4 · 2019: 11 · 2018: 4 · 2017: 11 · 2016: 6 · 2015: 9 · 2014: 4 · 2013: 9 · 2012: 10
- FWCI
- 9.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Prion Diseases and Protein Misfolding
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Amyloidosis: Diagnosis, Treatment, Outcomes
- Keywords
- prions, amyloid, Alzheimer's disease, prion disease, Creutzfeldt-Jakob disease, kuru, Gerstmann-Sträussler-Scheinker disease, scrapie
- MeSH terms
- Aged, Alzheimer Disease, Amyloid, Animals, Brain, Humans, Creutzfeldt-Jakob Syndrome, Prions, Slow Virus Diseases, Viral Proteins
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