Cited by 3,125Heart Failure Treatment and ManagementElectrolyte and hormonal disordersCardiac Fibrosis and Remodeling

The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.

Plasma Norepinephrine as a Guide to Prognosis in Patients with Chronic Congestive Heart Failure

Cohn, Jay N., Levine, T. Barry, Olivari, Maria Teresa, Garberg, Victoria, Lura, Dennis, Francis, Gary S., Simon, Ada B., Rector, Thomas·1984·New England Journal of Medicine

DOI 10.1056/nejm198409273111303

Open this paper in CoChat — free account

Abstract

Hemodynamics, plasma norepinephrine, and plasma renin activity were measured at supine rest in 106 patients (83 men and 23 women) with moderate to severe congestive heart failure. During follow-up lasting 1 to 62 months, 60 patients died (57 per cent); 47 per cent of the deaths were sudden, and 45 per cent were related to progressive heart failure. Statistically unrelated to the risk of mortality were cause of disease (60 patients had coronary disease, and 46 had cardiomyopathy), age (mean, 54.8 years), cardiac index (mean, 2.11 liters per minute per square meter of body-surface area), pulmonary wedge pressure (mean, 24.5 mm Hg), and mean arterial pressure (mean, 83.2 mm Hg). A multivariate analysis of the five significant univariate prognosticators--heart rate (mean, 84.4 beats per minute), plasma renin activity (mean, 15.4 ng per milliliter per hour), plasma norepinephrine (mean, 700 pg per milliliter), serum sodium (mean, 135.7 mmol per liter), and stroke-work index (mean, 21.0 g-meters per square meter)--found only plasma norepinephrine to be independently (P = 0.002) related to the subsequent risk of mortality. Norepinephrine was also higher in patients who died from progressive heart failure than in those who died suddenly. These data suggest that a single resting venous blood sample showing the plasma norepinephrine concentration provides a better guide to prognosis than other commonly measured indexes of cardiac performance.

Integrity signals

Registry

Crossref · 10.1056/nejm198409273111303

Cites

23 of 23 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Nonparametric Estimation from Incomplete Observations
Kaplan, E. L., & Meier, P. (1958) · Journal of the American Statistical Association · doi:10.1080/01621459.1958.10501452 · Cited by 39,158
Fundamentals of Biostatistics.
(1969) · Annals of Internal Medicine · doi:10.7326/0003-4819-70-4-873 · Cited by 4,573
A Generalized Wilcoxon Test for Comparing Arbitrarily Singly-Censored Samples
Gehan, E. A. (1965) · Biometrika · doi:10.1093/biomet/52.1-2.203 · Cited by 3,407
Plasma norepinephrine in congestive heart failure
Thomas, J. A., & Marks, B. H. (1978) · The American Journal of Cardiology · doi:10.1016/0002-9149(78)90162-5 · Cited by 925
A simplified radiometric assay for plasma norepinephrine and epinephrine
Passon, P. G., & Peuler, J. D. (1973) · Analytical Biochemistry · doi:10.1016/0003-2697(73)90517-4 · Cited by 637
Activity of the sympathetic nervous system and renin-angiotensin system assessed by plasma hormone levels and their relation to hemodynamic abnormalities in congestive heart failure
Levine, T. B., Francis, G. S., Goldsmith, S. R., Simon, A. B., & Cohn, J. N. (1982) · The American Journal of Cardiology · doi:10.1016/0002-9149(82)90243-0 · Cited by 614
Self-citation
Use of plasma norepinephrine for evaluation of sympathetic neuronal function in man
Lake, C., Ziegler, M. G., & Kopin, I. J. (1976) · Life Sciences · doi:10.1016/0024-3205(76)90210-1 · Cited by 548
Determinants of Survival in Patients with Ventricular Tachyarrhythmias
Swerdlow, C. D., Winkle, R. A., & Mason, J. W. (1983) · New England Journal of Medicine · doi:10.1056/nejm198306163082402 · Cited by 508
Comparative assessment of stimuli that release neuronal and adrenomedullary catecholamines in man.
Robertson, D., Johnson, G., Robertson, R. M., Nies, A. S., Shand, D. G., & Oates, J. A. (1979) · Circulation · doi:10.1161/01.cir.59.4.637 · Cited by 467
Augmentation of the Plasma Nor-Epinephrine Response to Exercise in Patients with Congestive Heart Failure
Chidsey, C. A., Harrison, D. C., & D, E. B. M. (1962) · New England Journal of Medicine · doi:10.1056/nejm196209272671305 · Cited by 439

Show all 23 references

Research works printed but not linked: 2

Hopkins A. Survival analysis with covariates — Cox models. In: BMDP statistical software. Berkeley, Calif.: University of California Press, 1983: 576–94.
10.2307/2281868 · DOI · Paper page

Sorted by citations

Items 401–500 of 1,002

Acute hemodynamic and neurohumoral effects of selective ETA receptor blockade in patients with congestive heart failure
Spieker, L. E., Mitrović, V. L., Noll, G., Pacher, R., Schulze, M. R., Muntwyler, J., Schalcher, C., Kiowski, W., & Lüscher, T. F. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(00)00649-5 · Cited by 118
Effect of Sympathectomy on Mechanical Properties of Common Carotid and Femoral Arteries
Mangoni, A. A., Mircoli, L., Giannattasio, C., Mancia, G., & Ferrari, A. U. (1997) · Hypertension · doi:10.1161/01.hyp.30.5.1085 · Cited by 118
Acute Effects of β 1 -Selective and Nonselective β-Adrenergic Receptor Blockade on Cardiac Sympathetic Activity in Congestive Heart Failure
Newton, G. E., & Parker, J. D. (1996) · Circulation · doi:10.1161/01.cir.94.3.353 · Cited by 117
Myocardial contractile reserve on dobutamine echocardiography predicts late spontaneous improvement in cardiac function in patients with recent onset idiopathic dilated cardiomyopathy
Naqvi, T. Z., Goel, R. K., Forrester, J. S., & Siegel, R. J. (1999) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00371-x · Cited by 117
Impact of converting enzyme inhibition on progression of chronic heart failure: results of the Munich Mild Heart Failure Trial.
Kleber, F. X., Niemöller, L., & Doering, W. (1992) · Heart · doi:10.1136/hrt.67.4.289 · Cited by 117
Enhanced G i Signaling Selectively Negates β 2 -Adrenergic Receptor (AR)– but Not β 1 -AR–Mediated Positive Inotropic Effect in Myocytes From Failing Rat Hearts
Xiao, R.-P., Zhang, S.-J., Chakir, K., Avdonin, P. V., Zhu, W., Bond, R. A., Balke, C. W., Lakatta, E. G., & Cheng, H. (2003) · Circulation · doi:10.1161/01.cir.0000087595.17277.73 · Cited by 116
Fixing ryanodine receptor Ca2+ leak – a novel therapeutic strategy for contractile failure in heart and skeletal muscle
Andersson, D. C., & Marks, A. R. (2010) · Drug Discovery Today Disease Mechanisms · doi:10.1016/j.ddmec.2010.09.009 · Cited by 115
Abnormalities of calcium metabolism and myocardial contractility depression in the failing heart
Lehnart, S. E., Maier, L. S., & Hasenfuss, G. P. (2009) · Heart Failure Reviews · doi:10.1007/s10741-009-9146-x · Cited by 115
Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling
Liu, C.-H., Gong, Z., Liang, Z.-L., Liu, Z.-X., Yang, F., Sun, Y., Ma, M.-L., Wang, Y.-J., Ji, C.-R., Wang, Y.-H., et al. (2017) · Nature Communications · doi:10.1038/ncomms14335 · Cited by 116
Effects of enalapril and neuroendocrine activation on prognosis in severe congestive heart failure (follow-up of the CONSENSUS trial)
Swedberg, K. B., Eneroth, P. H. E., KJEKSHUS, J. K., & Snapinn, S. (1990) · The American Journal of Cardiology · doi:10.1016/0002-9149(90)90475-g · Cited by 114
123I-mIBG Scintigraphy to predict risk for adverse cardiac outcomes in heart failure patients: Design of two prospective multicenter international trials
Jacobson, A. F., Lombard, J., Banerjee, G., & Camici, P. G. (2009) · Journal of Nuclear Cardiology · doi:10.1007/s12350-008-9008-2 · Cited by 112
The Neuronal Norepinephrine Transporter in Experimental Heart Failure: Evidence for a Posttranscriptional Downregulation
Backs, J., Haunstetter, A., Gerber, S. H., Metz, J., Borst, M. M., Strasser, R. H., Kübler, W., & Haass, M. (2001) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2000.1319 · Cited by 113
The effect of treatment with angiotensin-converting enzyme inhibitors on survival of pediatric patients with dilated cardiomyopathy
Lewis, A. B., & Chabot, M. (1993) · Pediatric Cardiology · doi:10.1007/bf00794837 · Cited by 113
Increased Sympathetic Nervous Activity and the Effects of Its Inhibition with Clonidine in Alcoholic Cirrhosis
Esler, M., Dudley, F., Jennings, G., Debinski, H. S., Lambert, G. W., Jones, P., Crotty, B. J., Colman, J. C., & Willett, I. R. (1992) · Annals of Internal Medicine · doi:10.7326/0003-4819-116-6-446 · Cited by 112
Effects of Amlodipine and Cilnidipine on Cardiac Sympathetic Nervous System and Neurohormonal Status in Essential Hypertension
Sakata, K., Shirotani, M., Yoshida, H., Nawada, R., Obayashi, K., Togi, K., & Miho, N. (1999) · Hypertension · doi:10.1161/01.hyp.33.6.1447 · Cited by 111
Neurohumoral responses to chronic myocardial infarction in rats.
Hodsman, G. P., Kohzuki, M., Howes, L. G., Sumithran, E., Tsunoda, K., & Johnston, C. I. (1988) · Circulation · doi:10.1161/01.cir.78.2.376 · Cited by 111
Reduction of Sympathetic Activity via Adrenal-targeted GRK2 Gene Deletion Attenuates Heart Failure Progression and Improves Cardiac Function after Myocardial Infarction
Lymperopoulos, A., Rengo, G., Gao, E., Ebert, S. N., Dorn, G. W., & Koch, W. J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.077859 · Cited by 111
Remodelling of cardiac repolarization: how homeostatic responses can lead to arrhythmogenesis
Michael, G., Xiao, L., Qi, X., Dobrev, D., & Nattel, S. (2008) · Cardiovascular Research · doi:10.1093/cvr/cvn266 · Cited by 111
An α 2C -Adrenergic Receptor Polymorphism Alters the Norepinephrine-Lowering Effects and Therapeutic Response of the β-Blocker Bucindolol in Chronic Heart Failure
Bristow, M. R., Murphy, G. A., Krause-Steinrauf, H. J., Anderson, J. L., Carlquist, J. F., Thaneemit-Chen, S., Krishnan, V., Abraham, W. T., Lowes, B. D., Port, J. D., et al. (2009) · Circulation Heart Failure · doi:10.1161/circheartfailure.109.885962 · Cited by 111
Novel Biomarkers of Heart Failure
Savic-Radojevic, A. R., Pljesa-Ercegovac, M. S., Matic, M., Simic, D., Radovanović, S., & Simic, T. P. (2016) · Advances in clinical chemistry · doi:10.1016/bs.acc.2016.09.002 · Cited by 113
Neurohumoral Stimulation
Zucker, I. H., Patel, K. P., & Schultz, H. D. (2011) · Heart Failure Clinics · doi:10.1016/j.hfc.2011.08.007 · Cited by 111
Interactions Between Phospholamban and β-Adrenergic Drive May Lead to Cardiomyopathy and Early Mortality
Dash, R., Kadambi, V. J., Schmidt, A. G., Tepe, N. M., Biniakiewicz, D. S., Gerst, M. J., Canning, A. M., Abraham, W. T., Hoit, B. D., Liggett, S. B., et al. (2001) · Circulation · doi:10.1161/01.cir.103.6.889 · Cited by 111
Drug discovery for heart failure: a new era or the end of the pipeline?
Kaye, D. M., & Krum, H. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2219 · Cited by 114
Depressive Symptoms and 24-Hour Urinary Norepinephrine Excretion Levels in Patients With Coronary Disease: Findings From the Heart and Soul Study
Otte, C., Neylan, T. C., Pipkin, S. S., Browner, W. S., & Whooley, M. A. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.11.2139 · Cited by 116
Poor survival of patients with idiopathic cardiomyopathy considered too well for transplantation
Stevenson, L. W., Fowler, M. B., SCHROEDER, J. S., Stevenson, W. G., Dracup, K., & Fond, V. (1987) · The American Journal of Medicine · doi:10.1016/0002-9343(87)90644-9 · Cited by 111
Overweight and Sympathetic Overactivity in Black Americans
Abate, N. I., Mansour, Y., Tuncel, M., Arbique, D., Chavoshan, B., Kizilbash, A. M., Howell‐Stampley, T., Vongpatanasin, W., & Victor, R. G. (2001) · Hypertension · doi:10.1161/01.hyp.38.3.379 · Cited by 110
Catecholamines 101
Goldstein, D. S. (2010) · Clinical Autonomic Research · doi:10.1007/s10286-010-0065-7 · Cited by 112
Long-term efficacy and safety of coenzyme Q10 therapy for idiopathic dilated cardiomyopathy
Langsjoen, P. H., Langsjoen, P. H., & Folkers, K. (1990) · The American Journal of Cardiology · doi:10.1016/0002-9149(90)90824-k · Cited by 110
Effect of long-term enalapril therapy on neurohormones in patients with left ventricular dysfunction
Benedict, C. R., Francis, G. S., Shelton, B. J., Johnstone, D. E., Kubo, S. H., Kirlin, P. C., Nicklas, J. M., Liang, C., Konstam, M. A., Greenberg, B., et al. (1995) · The American Journal of Cardiology · doi:10.1016/s0002-9149(99)80748-6 · Cited by 110
Self-citation
Neurohormonal Modulation of the Innate Immune System Is Proinflammatory in the Prehypertensive Spontaneously Hypertensive Rat, a Genetic Model of Essential Hypertension
Harwani, S. C., Chapleau, M. W., Legge, K. L., Ballas, Z. K., & Abboud, F. M. (2012) · Circulation Research · doi:10.1161/circresaha.112.277475 · Cited by 110
Attenuation of Systolic Blood Pressure and Pulse Transit Time Hysteresis During Exercise and Recovery in Cardiovascular Patients
Liu, Q., Yan, B. P., Yu, C., Zhang, Y., & Poon, C. C. Y. (2013) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2013.2286998 · Cited by 110
Sympathetic neuronal regulation of the heart in aging and heart failure
Kaye, D. M., & Esler, M. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.02.012 · Cited by 110
Activation of Protein Kinase A Modulates Trafficking of the Human Cardiac Sodium Channel in Xenopus Oocytes
Zhou, J., Yi, J., Hu, N., George, A. L., & Murray, K. T. (2000) · Circulation Research · doi:10.1161/01.res.87.1.33 · Cited by 109
Value of cardiopulmonary exercise testing and big endothelin plasma levels to predict short-term prognosis of patients with chronic heart failure
Hülsmann, M., Stanek, B., Frey, B., Sturm, B., Putz, D., Kos, T., Berger, R., Woloszczuk, W., Maurer, G., & Pacher, R. (1998) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(98)00437-9 · Cited by 109
The impact of ethnicity on response to antihypertensive therapy
Jamerson, K., & DeQuattro, V. L. (1996) · The American Journal of Medicine · doi:10.1016/s0002-9343(96)00265-3 · Cited by 109
Altered Calcium Handling Is Critically Involved in the Cardiotoxic Effects of Chronic β-Adrenergic Stimulation
Engelhardt, S. H., Hein, L., Dyachenkow, V., Kranias, E. G., Isenberg, G., & Lohse, M. J. (2004) · Circulation · doi:10.1161/01.cir.0000117254.68497.39 · Cited by 108
Acupuncture inhibits sympathetic activation during mental stress in advanced heart failure patients
Middlekauff, H. R., Hui, K.-K. P., Yu, J. L., Hamilton, M. A., Fonarow, G. C., Moriguchi, J. D., MacLellan, W. R., & Hage, A. (2002) · Journal of Cardiac Failure · doi:10.1054/jcaf.2002.129656 · Cited by 106
Selective regulation of β1‐and β2‐adrenoceptors in the human heart by chronic β‐adrenoceptor antagonist treatment
Michel, M. C., Pingsmann, A., Beckeringh, J., Zerkowski, H., Doetsch, N., & Brodde, O. (1988) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1988.tb11576.x · Cited by 115
The role of sympathetic nervous activity in renal injury and end-stage renal disease
Masuo, K., Lambert, G. W., Esler, M., Rakugi, H., Ogihara, T., & Schlaich, M. P. (2010) · Hypertension Research · doi:10.1038/hr.2010.35 · Cited by 107
The role of thoracic ultrasonography for evaluation of patients with decompensated chronic heart failure
Kataoka, H., & Takada, S. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(00)00602-1 · Cited by 107
A controlled study of the autonomic changes produced by habitual cigarette smoking in healthy subjects
Lucini, D., Bertocchi, F., Malliani, A., & Pagani, M. (1996) · Cardiovascular Research · doi:10.1016/s0008-6363(96)00013-2 · Cited by 107
Baroreflex control of renal sympathetic nerve activity is preserved in heart failure despite reduced arterial baroreceptor sensitivity.
Dibner‐Dunlap, M. E., & Thames, M. D. (1989) · Circulation Research · doi:10.1161/01.res.65.6.1526 · Cited by 107
Impact of Sleep Apnea on Sympathetic Nervous System Activity in Heart Failure
Solin, P., Kaye, D. M., Little, P. J., Bergin, P. J., Richardson, M., & Naughton, M. T. (2003) · CHEST Journal · doi:10.1378/chest.123.4.1119 · Cited by 107
Obstructive sleep apnea syndrome and autonomic dysfunction
Lombardi, C., Pengo, M. F., & Parati, G. (2019) · Autonomic Neuroscience · doi:10.1016/j.autneu.2019.102563 · Cited by 106
Inflammatory cytokines in paraventricular nucleus modulate sympathetic activity and cardiac sympathetic afferent reflex in rats
Shi, Z., Gan, X.-B., Fan, Z. ‐., Zhang, F., Zhou, Y., Gao, X., De, W., & Zhu, G. (2011) · Acta Physiologica · doi:10.1111/j.1748-1716.2011.02313.x · Cited by 106
Relation between left ventricular shape and exercise capacity in patients with left ventricular dysfunction
Tischler, M. D., Niggel, J. B., Borowski, D. T., & LeWinter, M. M. (1993) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(93)90187-6 · Cited by 106
Congestive Heart Failure: Diagnosis, Pathophysiology, Therapy, and Implications for Respiratory Care
Figueroa, M. S., & Peters, J. I. (2006) · Respiratory Care · doi:10.4187/respcare.06510403 · Cited by 109
Prognostic Value of Serial Cardiac 123I-MIBG Imaging in Patients with Stabilized Chronic Heart Failure and Reduced Left Ventricular Ejection Fraction
Kasama, S., Toyama, T., Sumino, H., Nakazawa, M., Matsumoto, N., Sato, Y., Kumakura, H., Takayama, Y., Ichikawa, S., Suzuki, T., et al. (2008) · Journal of Nuclear Medicine · doi:10.2967/jnumed.107.047548 · Cited by 105
Resistance exercise training increases muscle strength, endurance, and blood flow in patients with chronic heart failure
Hare, D. L., Ryan, T. M., Selig, S., Pellizzer, A., Wrigley, T. V., & Krum, H. (1999) · The American Journal of Cardiology · doi:10.1016/s0002-9149(99)00179-4 · Cited by 106
Inflammatory Biomarkers in Heart Failure Revisited: Much More than Innocent Bystanders
von Haehling, S., Schefold, J. C., Lainščak, M., Doehner, W., & Anker, S. D. (2009) · Heart Failure Clinics · doi:10.1016/j.hfc.2009.04.001 · Cited by 102
Resting Heart Rate as Predictor for Left Ventricular Dysfunction and Heart Failure
Opdahl, A., Ambale‐Venkatesh, B., Fernandes, V., Wu, C. O., Nasir, K., Choi, E., de Almeida, A. L. C., Rosen, B. D., Carvalho, B. S., Edvardsen, T., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.11.027 · Cited by 105
Improved Survival with Bisoprolol in Patients with Heart Failure and Renal Impairment: An Analysis of the Cardiac Insufficiency Bisoprolol Study II (CIBIS-II) Trial
Castagno, D., Jhund, P. S., McMurray, J. J. V., Lewsey, J., Erdmann, E., Zannad, F. M., Remme, W. J., Lopez-Sendon, J. L., Lechat, P. P., Folláth, F., et al. (2010) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfq038 · Cited by 106
Prognostic importance of hyponatremia in acute ST-elevation myocardial infarction
Goldberg, A., Hammerman, H., Petcherski, S., Zdorovyak, A., Yalonetsky, S., Kapeliovich, M. R., Agmon, Y., Markiewicz, W., & Aronson, D. (2004) · The American Journal of Medicine · doi:10.1016/j.amjmed.2004.03.022 · Cited by 105
Measurement of Sympathetic Nervous System Activity in Heart Failure: The Role of Norepinephrine Kinetics
Esler, M., & Kaye, D. M. (2000) · Heart Failure Reviews · doi:10.1023/a:1009889922985 · Cited by 103
β-ADRENERGIC RECEPTOR REGULATION IN THE HEART IN PATHOPHYSIOLOGIC STATES: ABNORMAL ADRENERGIC RESPONSIVENESS IN CARDIAC DISEASE
Homcy, C. J., Vatner, S. F., & Vatner, D. E. (1991) · Annual Review of Physiology · doi:10.1146/annurev.ph.53.030191.001033 · Cited by 105
Pathophysiology and treatment of Cheyne-Stokes respiration
Naughton, M. T. (1998) · Thorax · doi:10.1136/thx.53.6.514 · Cited by 104
Modulation of the myocardial redox state by vagal nerve stimulation after experimental myocardial infarction
Tsutsumi, T., Ide, T., Yamato, M., Kudou, W., Andou, M., Hirooka, Y., Utsumi, H., Tsutsui, H., & Sunagawa, K. (2007) · Cardiovascular Research · doi:10.1093/cvr/cvm092 · Cited by 104
Sympathetic activation in human heart failure: diverse mechanisms, therapeutic opportunities
Floras, J. S. (2003) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2003.01087.x · Cited by 104
Sympathetic Activation in Heart Failure and Its Treatment With β-Blockade
Pepper, G. S., & Lee, R. W. (1999) · Archives of Internal Medicine · doi:10.1001/archinte.159.3.225 · Cited by 104
Sympathetic Modulation of Radial Artery Compliance in Congestive Heart Failure
Grassi, G. M., Giannattasio, C., Failla, M., Pesenti, A. M., Peretti, G., Marinoni, E. C., Fraschini, N., Vailati, S., & Mancia, G. (1995) · Hypertension · doi:10.1161/01.hyp.26.2.348 · Cited by 104
Protective effects of carvedilol against doxorubicin-induced cardiomyopathy in rats
Matsui, H., Morishima, I., Numaguchi, Y., Toki, Y., Okumura, K., & Hayakawa, T. (1999) · Life Sciences · doi:10.1016/s0024-3205(99)00362-8 · Cited by 103
Direct Inhibition of Type 5 Adenylyl Cyclase Prevents Myocardial Apoptosis without Functional Deterioration
Iwatsubo, K., Minamisawa, S., Tsunematsu, T., Nakagome, M., Toya, Y., Tomlinson, J. E., Umemura, S., Scarborough, R. M., Levy, D. E., & Ishikawa, Y. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m314238200 · Cited by 103
Prognosis determination in heart failure
Eichhorn, E. J. (2001) · The American Journal of Medicine · doi:10.1016/s0002-9343(98)00384-2 · Cited by 102
Role of cytokines in heart failure
Blum, A., & Miller, H. (1998) · American Heart Journal · doi:10.1016/s0002-8703(98)70080-8 · Cited by 103
Cyclic nucleotide phosphodiesterases as therapeutic targets in cardiac hypertrophy and heart failure
Kamel, R., Leroy, J., Vandecasteele, G., & Fischmeister, R. (2022) · Nature Reviews Cardiology · doi:10.1038/s41569-022-00756-z · Cited by 100
Targeted Anticytokine Therapy and the Failing Heart
Mann, D. L. (2005) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2005.03.007 · Cited by 102
The paradox of β-adrenergic blockade for the management of congestive heart failure
Eichhorn, E. J. (1992) · The American Journal of Medicine · doi:10.1016/0002-9343(92)90750-6 · Cited by 102
β-adrenergic blockade in chronic heart failure: Principles, progress, and practice
Packer, M. (1998) · Progress in Cardiovascular Diseases · doi:10.1016/s0033-0620(98)80030-3 · Cited by 102
Impact of Acute Mental Stress on Sympathetic Nerve Activity and Regional Blood Flow in Advanced Heart Failure
Middlekauff, H. R., Nguyen, A. H., Negrão, C. E., Nitzsche, E. U., Hoh, C. K., Natterson-Horowitz, B., Hamilton, M. A., Fonarow, G. C., Hage, A., & Moriguchi, J. D. (1997) · Circulation · doi:10.1161/01.cir.96.6.1835 · Cited by 97
Sympathetic Nervous System Function and Dysfunction in Chronic Hemodialysis Patients
Rubinger, D., Backenroth, R., & Sapoznikov, D. (2013) · Seminars in Dialysis · doi:10.1111/sdi.12093 · Cited by 101
Effects of Sustained-Release Moxonidine, an Imidazoline Agonist, on Plasma Norepinephrine in Patients With Chronic Heart Failure
Swedberg, K. B., Bristow, M. R., Cohn, J. N., Dargie, H., Straub, M., Wiltse, C. G., & Wright, T. J. (2002) · Circulation · doi:10.1161/01.cir.0000014212.04920.62 · Cited by 101
Self-citation
Characterization of the hyperpolarization-activated inward current in isolated human atrial myocytes.
Hoppe, U. C., & Beuckelmann, D. J. (1998) · Cardiovascular Research · doi:10.1016/s0008-6363(98)00047-9 · Cited by 104
Electrical and structural remodeling of the failing ventricle
Armoundas, A. A., Wu, R., Juang, G., Marbán, E., & Tomaselli, G. F. (2001) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(01)00171-1 · Cited by 98
Acupuncture in Polycystic Ovary Syndrome: Current Experimental and Clinical Evidence
Stener‐Victorin, E., Jedel, E., & Mannerås, L. (2007) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2007.01634.x · Cited by 100
Dilated cardiomyopathy: an update
O’Grady, M. R., & O’Sullivan, M. L. (2004) · Veterinary Clinics of North America Small Animal Practice · doi:10.1016/j.cvsm.2004.05.009 · Cited by 100
Evaluation of Sympathetic Nerve Terminals With [ 11 C]Epinephrine and [ 11 C]Hydroxyephedrine and Positron Emission Tomography
Münch, G., Nguyen, N. T., Nekolla, S. G., Ziegler, S. I., Muzik, O., Chakraborty, P. K., Wieland, D. M., & Schwaiger, M. (2000) · Circulation · doi:10.1161/01.cir.101.5.516 · Cited by 100
Effects of Hypertension and Obesity on the Sympathetic Activation of Heart Failure Patients
Grassi, G. M., Seravalle, G., Quarti‐Trevano, F., Dell’Oro, R., Bolla, G. B., & Mancia, G. (2003) · Hypertension · doi:10.1161/01.hyp.0000098660.26184.63 · Cited by 100
β-Adrenergic Blocking Agents in Heart Failure
Bonet, S., Agustí, A., Arnau, J. M., Vidal, X., Diogène, E., Galve, E., & Laporte, J. (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.5.621 · Cited by 100
New aspects for the role of physical training in the management of patients with chronic heart failure
Adamopoulos, S. N., Parissis, J., & Kremastinos, D. T. (2003) · International Journal of Cardiology · doi:10.1016/s0167-5273(02)00504-1 · Cited by 99
Emerging concepts and therapeutic implications of β-adrenergic receptor subtype signaling
Zheng, M., Zhu, W., Han, Q., & Xiao, R. (2005) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.04.006 · Cited by 102
Brain Natriuretic Peptide in the Management of Heart Failure
de Denus, S., Pharand, C., & Williamson, D. R. (2004) · CHEST Journal · doi:10.1378/chest.125.2.652 · Cited by 98
Baroreceptor function during exercise: resetting the record
Joyner, M. J. (2005) · Experimental Physiology · doi:10.1113/expphysiol.2005.032102 · Cited by 99
Severely Impaired Cardiac Autonomic Nervous Activity After the Fontan Operation
Ohuchi, H., Hasegawa, S., Yasuda, K., Yamada, O., Ono, Y., & Echigo, S. (2001) · Circulation · doi:10.1161/hc3801.096326 · Cited by 99
Mechanisms underpinning sympathetic nervous activity and its modulation using transcutaneous vagus nerve stimulation
Deuchars, S. A., Lall, V. K., Clancy, J., Mahadi, M., Murray, A., Peers, L., & Deuchars, J. (2018) · Experimental Physiology · doi:10.1113/ep086433 · Cited by 98
Are the pharmacology and physiology of α2adrenoceptors determined by α2‐heteroreceptors and autoreceptors respectively?
Gilsbach, R., & Hein, L. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01533.x · Cited by 97
The cardiac sympathetic co-transmitter galanin reduces acetylcholine release and vagal bradycardia: Implications for neural control of cardiac excitability
Herring, N., Cranley, J. J., Lokale, M. N., Li, D., Shanks, J. A., Alston, E. N., Girard, B. M., Carter, E., Parsons, R. L., Habecker, B. A., et al. (2011) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2011.11.016 · Cited by 98
Selenium deficiency associated porcine and human cardiomyopathies
Oropeza-Moe, M., Wisløff, H., & Bernhoft, A. (2014) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2014.09.011 · Cited by 98
Biological Serum Markers in the Management of Pediatric Pulmonary Arterial Hypertension
van Albada, M. E., Loot, F. G., Fokkema, R., Roofthooft, M. T. R., & Berger, R. M. F. (2008) · Pediatric Research · doi:10.1203/pdr.0b013e318163a2e7 · Cited by 98
Randomised controlled trial of continuous positive airway pressure and standard oxygen therapy in acute pulmonary oedema. Effects on plasma brain natriuretic peptide concentrations
Kelly, C. A. (2002) · European Heart Journal · doi:10.1053/euhj.2001.3156 · Cited by 98
The pathophysiology of advanced heart failure
Baig, M. K., Mahon, N., McKenna, W. J., Caforio, A. L. P., Bonow, R. O., Francis, G. S., & Gheorghiade, M. (1998) · American Heart Journal · doi:10.1016/s0002-8703(98)70252-2 · Cited by 97
Self-citation
Cardiac natriuretic hormones, neuro-hormones, thyroid hormones and cytokines in normal subjects and patients with heart failure
Emdin, M., Passino, C., Prontera, C., Iervasi, A., Ripoli, A., Masini, S., Zucchelli, G. C., & Clerico, A. (2004) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2004.108 · Cited by 97
Intense Sympathetic Nerve Activity in Adults with Hypopituitarism and Untreated Growth Hormone Deficiency1
Sverrisdóttir, Y. B., Elam, M., Herlitz, H., Bengtsson, B., & Johannsson, G. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.6.4895 · Cited by 97
Tracer norepinephrine kinetics in coronary circulation of patients with heart failure secondary to chronic pressure and volume overload.
Rose, C. P., Burgess, J. H., & Cousineau, D. (1985) · Journal of Clinical Investigation · doi:10.1172/jci112164 · Cited by 97
Effect of partial fatty acid oxidation inhibition with trimetazidine on mortality and morbidity in heart failure: Results from an international multicentre retrospective cohort study
Fragasso, G., Rosano, G. M. C., Baek, S. H., Sisakian, H. S., Napoli, P. D., Alberti, L., Calori, G., Kang, S., Sahakyan, L. G., Sanosyan, A., et al. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.09.123 · Cited by 96
Firing Properties of Single Muscle Vasoconstrictor Neurons in the Sympathoexcitation Associated With Congestive Heart Failure
Macefield, V. G., Rundqvist, B., Sverrisdóttir, Y. B., Wallin, B. G., & Elam, M. (1999) · Circulation · doi:10.1161/01.cir.100.16.1708 · Cited by 96
C-Reactive Protein in Dilated Cardiomyopathy
Kaneko, K., Kanda, T., Yamauchi, Y., Hasegawa, A., Iwasaki, T., Arai, M., Suzuki, T., Kobayashi, I., & Nagai, R. (1999) · Cardiology · doi:10.1159/000006913 · Cited by 96
Activation of neurohumoral systems following acute myocardial infarction
Rouleau, J. L., Moyé, L. A., de Champlain, J., Klein, M. D., Bichet, D. G., Packer, M., Sussex, B. A., Arnold, J. M. O., Sestier, F., Parker, J. O., et al. (1991) · The American Journal of Cardiology · doi:10.1016/0002-9149(91)90264-l · Cited by 96
Characterization and autoradiographic localization of β‐adrenoceptor subtypes in human cardiac tissues
Buxton, B. F., Jones, C. R., Molenaar, P., & Summers, R. J. (1987) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1987.tb11324.x · Cited by 96
Sympathetic and renin-angiotensin-aldosterone system activation in heart failure with preserved, mid-range and reduced ejection fraction
Vergaro, G., Aimo, A., Prontera, C., Ghionzoli, N., Arzilli, C., Zyw, L., Taddei, C., Gabutti, A., Poletti, R., Giannoni, A., et al. (2019) · International Journal of Cardiology · doi:10.1016/j.ijcard.2019.08.040 · Cited by 96
SR calcium handling and calcium after-transients in a rabbit model of heart failure
Baartscheer, A., Schumacher, C. A., Belterman, C. N. W., Coronel, R., & Fiolet, J. W. T. (2003) · Cardiovascular Research · doi:10.1016/s0008-6363(02)00854-4 · Cited by 95

Authors: Cohn, J. N., Levine, T. B., Olivari, M. T., Garberg, V., Lura, D., Francis, G. S., Simon, A. B., & Rector, T.
Affiliations: University of Minnesota (US)
ORCID: Cohn, Jay N.
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 1984-09-27
Volume: 311
Issue: 13
Pages: 819-823
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejm198409273111303
OpenAlex: W2338638760
Cited by: 3,125
References: 23
Citations by year: 2026: 22 · 2025: 30 · 2024: 22 · 2023: 44 · 2022: 50 · 2021: 49 · 2020: 54 · 2019: 58 · 2018: 42 · 2017: 57 · 2016: 75 · 2015: 73 · 2014: 101 · 2013: 87 · 2012: 88
FWCI: 34.36
Type: journal article
Language: en
Open access: closed
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
Health Sciences › Medicine › Nephrology › Electrolyte and hormonal disorders
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
Keywords: plasma norepinephrine, congestive heart failure, prognosis, mortality risk, plasma renin activity, hemodynamics, sudden death, progressive heart failure, prognostic factors, heart rate, stroke work index, serum sodium
MeSH terms: Age Factors, Blood Pressure, Female, Follow-Up Studies, Heart Failure, Heart Rate, Hemodynamics, Humans, Male, Middle Aged, Norepinephrine, Prognosis, Pulmonary Wedge Pressure, Renin

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Plasma Norepinephrine as a Guide to Prognosis in Patients with Chronic Congestive Heart Failure

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks