Cited by 3,125Heart Failure Treatment and ManagementElectrolyte and hormonal disordersCardiac Fibrosis and Remodeling

The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.

Plasma Norepinephrine as a Guide to Prognosis in Patients with Chronic Congestive Heart Failure

Cohn, Jay N., Levine, T. Barry, Olivari, Maria Teresa, Garberg, Victoria, Lura, Dennis, Francis, Gary S., Simon, Ada B., Rector, Thomas·1984·New England Journal of Medicine

DOI 10.1056/nejm198409273111303

Open this paper in CoChat — free account

Abstract

Hemodynamics, plasma norepinephrine, and plasma renin activity were measured at supine rest in 106 patients (83 men and 23 women) with moderate to severe congestive heart failure. During follow-up lasting 1 to 62 months, 60 patients died (57 per cent); 47 per cent of the deaths were sudden, and 45 per cent were related to progressive heart failure. Statistically unrelated to the risk of mortality were cause of disease (60 patients had coronary disease, and 46 had cardiomyopathy), age (mean, 54.8 years), cardiac index (mean, 2.11 liters per minute per square meter of body-surface area), pulmonary wedge pressure (mean, 24.5 mm Hg), and mean arterial pressure (mean, 83.2 mm Hg). A multivariate analysis of the five significant univariate prognosticators--heart rate (mean, 84.4 beats per minute), plasma renin activity (mean, 15.4 ng per milliliter per hour), plasma norepinephrine (mean, 700 pg per milliliter), serum sodium (mean, 135.7 mmol per liter), and stroke-work index (mean, 21.0 g-meters per square meter)--found only plasma norepinephrine to be independently (P = 0.002) related to the subsequent risk of mortality. Norepinephrine was also higher in patients who died from progressive heart failure than in those who died suddenly. These data suggest that a single resting venous blood sample showing the plasma norepinephrine concentration provides a better guide to prognosis than other commonly measured indexes of cardiac performance.

Integrity signals

Registry

Crossref · 10.1056/nejm198409273111303

Cites

23 of 23 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Nonparametric Estimation from Incomplete Observations
Kaplan, E. L., & Meier, P. (1958) · Journal of the American Statistical Association · doi:10.1080/01621459.1958.10501452 · Cited by 39,158
Fundamentals of Biostatistics.
(1969) · Annals of Internal Medicine · doi:10.7326/0003-4819-70-4-873 · Cited by 4,573
A Generalized Wilcoxon Test for Comparing Arbitrarily Singly-Censored Samples
Gehan, E. A. (1965) · Biometrika · doi:10.1093/biomet/52.1-2.203 · Cited by 3,407
Plasma norepinephrine in congestive heart failure
Thomas, J. A., & Marks, B. H. (1978) · The American Journal of Cardiology · doi:10.1016/0002-9149(78)90162-5 · Cited by 925
A simplified radiometric assay for plasma norepinephrine and epinephrine
Passon, P. G., & Peuler, J. D. (1973) · Analytical Biochemistry · doi:10.1016/0003-2697(73)90517-4 · Cited by 637
Activity of the sympathetic nervous system and renin-angiotensin system assessed by plasma hormone levels and their relation to hemodynamic abnormalities in congestive heart failure
Levine, T. B., Francis, G. S., Goldsmith, S. R., Simon, A. B., & Cohn, J. N. (1982) · The American Journal of Cardiology · doi:10.1016/0002-9149(82)90243-0 · Cited by 614
Self-citation
Use of plasma norepinephrine for evaluation of sympathetic neuronal function in man
Lake, C., Ziegler, M. G., & Kopin, I. J. (1976) · Life Sciences · doi:10.1016/0024-3205(76)90210-1 · Cited by 548
Determinants of Survival in Patients with Ventricular Tachyarrhythmias
Swerdlow, C. D., Winkle, R. A., & Mason, J. W. (1983) · New England Journal of Medicine · doi:10.1056/nejm198306163082402 · Cited by 508
Comparative assessment of stimuli that release neuronal and adrenomedullary catecholamines in man.
Robertson, D., Johnson, G., Robertson, R. M., Nies, A. S., Shand, D. G., & Oates, J. A. (1979) · Circulation · doi:10.1161/01.cir.59.4.637 · Cited by 467
Augmentation of the Plasma Nor-Epinephrine Response to Exercise in Patients with Congestive Heart Failure
Chidsey, C. A., Harrison, D. C., & D, E. B. M. (1962) · New England Journal of Medicine · doi:10.1056/nejm196209272671305 · Cited by 439

Show all 23 references

Research works printed but not linked: 2

Hopkins A. Survival analysis with covariates — Cox models. In: BMDP statistical software. Berkeley, Calif.: University of California Press, 1983: 576–94.
10.2307/2281868 · DOI · Paper page

Sorted by citations

Items 101–200 of 1,002

Prognostic Significance of Plasma Norepinephrine in Patients With Asymptomatic Left Ventricular Dysfunction
Benedict, C. R., Shelton, B. J., Johnstone, D. E., Francis, G. S., Greenberg, B., Konstam, M. A., Probstfield, J. L., & Yusuf, S. (1996) · Circulation · doi:10.1161/01.cir.94.4.690 · Cited by 355
Self-citation
Variable effects of explosive or gradual increase of intracranial pressure on myocardial structure and function.
Shivalkar, B., van Loon, J., Wieland, W., Tjandra-Maga, T., Borgers, M. J., Plets, C., & Flameng, W. (1993) · Circulation · doi:10.1161/01.cir.87.1.230 · Cited by 354
Advanced (Stage D) Heart Failure: A Statement From the Heart Failure Society of America Guidelines Committee
Fang, J. C., Ewald, G. A., Allen, L. A., Butler, J., Canary, C. A. W., Colvin, M. M., Dickinson, M. G., Levy, P. D., Stough, W. G., Sweitzer, N. K., et al. (2015) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2015.04.013 · Cited by 351
Prognostic importance of atrial natriuretic peptide in patients with chronic heart failure
Gottlieb, S. S., Kukin, M. L., Ahern, D., & Packer, M. (1989) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(89)90344-6 · Cited by 350
Sympathetic nervous activation in obesity and the metabolic syndrome—Causes, consequences and therapeutic implications
Lambert, G. W., Straznicky, N. E., Lambert, É., Dixon, J. B., & Schlaich, M. P. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.02.002 · Cited by 352
Treatment of Congestive Heart Failure and Cheyne-Stokes Respiration during Sleep by Continuous Positive Airway Pressure
Naughton, M. T., Liu, P. P., Bernard, D., Goldstein, R. S., & Bradley, T. D. (1995) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.151.1.7812579 · Cited by 343
Obstructive Sleep Apnea and Heart Failure
Kasai, T., & Bradley, T. D. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.08.627 · Cited by 359
The comparative prognostic value of plasma neurohormones at baseline in patients with heart failure enrolled in Val-HeFT
Latini, R. (2004) · European Heart Journal · doi:10.1016/j.ehj.2003.10.030 · Cited by 344
Decreased spontaneous heart rate variability in congestive heart failure
Casolo, G., Balli, E., Taddei, T., Amuhasi, J., & Gori, C. (1989) · The American Journal of Cardiology · doi:10.1016/0002-9149(89)90871-0 · Cited by 344
What is the optimal serum potassium level in cardiovascular patients?
Macdonald, J. E., & Struthers, A. D. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2003.06.021 · Cited by 355
A Randomized Controlled Trial of Adaptive Ventilation for Cheyne–Stokes Breathing in Heart Failure
Pepperell, J., Maskell, N. A., Jones, D. R., Langford, B., Crosthwaite, N., Stradling, J. R., & Davies, R. J. O. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200212-1476oc · Cited by 342
Prognostic impact of big endothelin-1 plasma concentrations compared with invasive hemodynamic evaluation in severe heart failure
Pacher, R., Stanek, B., Hülsmann, M., Koller-Strametz, J., Berger, R., Schuller, M., Hartter, E., Ogris, E., Frey, B., Heinz, G., et al. (1996) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(95)00520-x · Cited by 342
The effects of exercise training on sympathetic neural activation in advanced heart failure
Roveda, F., Middlekauff, H. R., Rondon, M. U. P. B., Reis, S. F., Souza, M., Nastari, L., Barretto, A. C. P., Krieger, E. M., & Negrão, C. E. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00831-3 · Cited by 333
Importance of hemodynamic response to therapy in predicting survival with ejection fraction ≤ 20% secondary to ischemic or nonischemic dilated cardiomyopathy
Stevenson, L. W., Tillisch, J. H., Hamilton, M. A., Luu, M., Chelimsky-Fallick, C., Moriguchi, J. D., KOBASHIGAWA, J. A., & Walden, J. A. (1990) · The American Journal of Cardiology · doi:10.1016/0002-9149(90)91166-4 · Cited by 333
Risk stratification after hospitalization for decompensated heart failure
Felker, G. M., Leimberger, J. D., Califf, R. M., Cuffe, M. S., Massie, B. M., Adams, K. F., Gheorghiade, M., & O’Connor, C. M. (2004) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2004.02.011 · Cited by 331
Acute Hemodynamic Improvement by Thermal Vasodilation in Congestive Heart Failure
Tei, C., Horikiri, Y., Park, J.-C., Jeong, J., Chang, K.-S., Toyama, Y., & Tanaka, N. (1995) · Circulation · doi:10.1161/01.cir.91.10.2582 · Cited by 329
Resolved and unresolved issues in the prevention and treatment of coronary artery disease: A workshop consensus statement
Dzau, V. J., & Braunwald, E. (1991) · American Heart Journal · doi:10.1016/0002-8703(91)90694-d · Cited by 330
Abnormal I-123 metaiodobenzylguanidine myocardial washout and distribution may reflect myocardial adrenergic derangement in patients with congestive cardiomyopathy.
Henderson, E. B., Kahn, J. K., Corbett, J. R., Jansen, D., Pippin, J. J., Kulkarni, P. V., Ugolini, V., Akers, M. S., Hansen, C. L., & Buja, L. M. (1988) · Circulation · doi:10.1161/01.cir.78.5.1192 · Cited by 324
Increase of Gi alpha in human hearts with dilated but not ischemic cardiomyopathy.
Böhm, M., Gierschik, P., Jakobs, K. H., Pieske, B. M., Schnabel, P., Ungerer, M., & Erdmann, E. (1990) · Circulation · doi:10.1161/01.cir.82.4.1249 · Cited by 324
Increased muscle sympathetic nerve activity predicts mortality in heart failure patients
Barretto, A. C. P., dos Santos, A. C., Munhoz, R. T., Rondon, M. U. P. B., Franco, F. G. D. M., Trombetta, I. C., Roveda, F., de Matos, L. D. N. J., Braga, A. M. W., Middlekauff, H. R., et al. (2008) · International Journal of Cardiology · doi:10.1016/j.ijcard.2008.03.056 · Cited by 323
Effects of short- and long-term carvedilol administration on rest and exercise hemodynamic variables, exercise capacity and clinical conditions in patients with idiopathic dilated cardiomyopathy
Metra, M., Nardi, M., Giubbini, R., & Cas, L. D. (1994) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(94)90174-0 · Cited by 321
A GRK5 polymorphism that inhibits β-adrenergic receptor signaling is protective in heart failure
Liggett, S. B., Cresci, S., Kelly, R. J., Syed, F. M., Matkovich, S. J., Hahn, H. S., Diwan, A., Martini, J. S., Sparks, L., Parekh, R. R., et al. (2008) · Nature Medicine · doi:10.1038/nm1750 · Cited by 322
Beta-adrenergic neuroeffector abnormalities in the failing human heart are produced by local rather than systemic mechanisms.
Bristow, M. R., Minobe, W. A., Rasmussen, R., Larrabee, P. S., Skerl, L., Klein, J., Anderson, F. L., Murray, J., Mestroni, L., & Karwande, S. V. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115659 · Cited by 320
β-Blocker Therapy in Heart Failure
Foody, J. M., Farrell, M. H., & Krumholz, H. M. (2002) · JAMA · doi:10.1001/jama.287.7.883 · Cited by 317
The Effectiveness and Relative Effectiveness of Intravenous Inotropic Drugs Acting Through the Adrenergic Pathway in Patients with Heart Failure—A Meta-Regression Analysis
Thackray, S. D. R., Easthaugh, J., Freemantle, N., & Cleland, J. G. F. (2002) · European Journal of Heart Failure · doi:10.1016/s1388-9842(02)00041-7 · Cited by 319
Neurohormonal activation in patients with right ventricular failure from pulmonary hypertension: Relation to hemodynamic variables and endothelin levels
Nootens, M., Kaufmann, E., Rector, T. S., Toher, C. A., Judd, D., Francis, G. S., & Rich, S. (1995) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(95)00399-1 · Cited by 317
Self-citation
Pulmonary Hypertension Predicts Mortality and Morbidity in Patients with Dilated Cardiomyopathy
Abramson, S. V., Burke, J. F., Kelly, J. J. P., Kitchen, J. G., Dougherty, M. J., Yih, D. F., McGeehin, F. C., Shuck, J. W., & Phiambolis, T. P. (1992) · Annals of Internal Medicine · doi:10.7326/0003-4819-116-11-888 · Cited by 312
Creatine Kinase System in Failing and Nonfailing Human Myocardium
Nascimben, L., Ingwall, J. S., Pauletto, P., Friedrich, J. O., Gwathmey, J. K., Saks, V. A., Pessina, A. C., & Allen, P. D. (1996) · Circulation · doi:10.1161/01.cir.94.8.1894 · Cited by 318
Increased Cardiac Adrenergic Drive Precedes Generalized Sympathetic Activation in Human Heart Failure
Rundqvist, B., Elam, M., Sverrisdóttir, Y. B., Eisenhofer, G., & Friberg, P. (1997) · Circulation · doi:10.1161/01.cir.95.1.169 · Cited by 308
Effects of Initiating Carvedilol in Patients With Severe Chronic Heart Failure
Krum, H., Roecker, E. B., Mohaçsi, P., Rouleau, J. L., Tendera, M., Coats, A. J. S., Katus, H. A., Fowler, M. B., Packer, M., & for the Carvedilol Prospective Randomized Cumulative Survival (COPERNICUS) Study Group (2003) · JAMA · doi:10.1001/jama.289.6.712 · Cited by 312
Continuous Autonomic Assessment in Patients With Symptomatic Heart Failure
Adamson, P. B., Smith, A. L., Abraham, W. T., Kleckner, K. J., Stadler, R. W., Shih, A., & Rhodes, M. (2004) · Circulation · doi:10.1161/01.cir.0000139841.42454.78 · Cited by 304
Effect of metoprolol on myocardial function and energetics in patients with nonischemic dilated cardiomyopathy: A randomized, double-blind, placebo-controlled study
Eichhorn, E. J., Heesch, C. M., Barnett, J. H., Alvarez, L. G., Fass, S. M., Grayburn, P. A., Hatfield, B. A., Marcoux, L., & Malloy, C. R. (1994) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(94)90114-7 · Cited by 305
Survival of patients with severe congestive heart failure treated with oral milrinone
Baim, D. S., Colucci, W. S., Monrad, E. S., Smith, H. S., Wright, R. F., Lanoue, A., Gauthier, D. F., Ransil, B. J., Grossman, W., & Braunwald, E. (1986) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(86)80478-8 · Cited by 310
Electrophysiological changes in heart failure and their relationship to arrhythmogenesis
Janse, M. J. (2003) · Cardiovascular Research · doi:10.1016/j.cardiores.2003.11.018 · Cited by 302
Increased plasma levels of adrenomedullin in patients with heart failure
Nishikimi, T., Saito, Y., Kitamura, K., Ishimitsu, T., Eto, T., Kangawa, K., Matsuo, H., Omae, T., & Matsuoka, H. (1995) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(95)00338-x · Cited by 302
Prognostic Impact of Plasma N-Terminal Pro–Brain Natriuretic Peptide in Severe Chronic Congestive Heart Failure
Hartmann, F. S., Packer, M., Coats, A. J. S., Fowler, M. B., Krum, H., Mohaçsi, P., Rouleau, J. L., Tendera, M., Castaigne, A., Anker, S. D., et al. (2004) · Circulation · doi:10.1161/01.cir.0000143059.68996.a7 · Cited by 301
Blood flow restriction training and the exercise pressor reflex: a call for concern
Spranger, M. D., Krishnan, A. C., Levy, P. D., O’Leary, D. S., & Smith, S. A. (2015) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00208.2015 · Cited by 293
The syndrome of cardiac cachexia
Anker, S. D., & Sharma, R. (2002) · International Journal of Cardiology · doi:10.1016/s0167-5273(02)00233-4 · Cited by 292
Relation Between Gender, Etiology and Survival in Patients With Symptomatic Heart Failure
Adams, K. F., Dunlap, S. H., Sueta, C. A., Clarke, S. W., Patterson, J. H., Blauwet, M. B., Jensen, L. R., Tomasko, L., & Koch, G. G. (1996) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(96)00380-4 · Cited by 289
Upregulation of aquaporin-2 water channel expression in chronic heart failure rat.
Xu, D., Martin, P., O'Hara, M., John, J. S., Pattison, T., Meng, X., Morris, K. G., Kim, J. K., & Schrier, R. W. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119312 · Cited by 286
Neurochemical evidence of cardiac sympathetic activation and increased central nervous system norepinephrine turnover in severe congestive heart failure
Kaye, D. M., Lambert, G. W., Lefkovits, J., Morris, M. J., Jennings, G., & Esler, M. (1994) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(94)90738-2 · Cited by 285
Prognostic value of neurohumoral activation in patients with an acute myocardial infarction: Effect of captopril
Rouleau, J. L., Packer, M., Moyé, L., de Champlain, J., Bichet, D., Klein, M., Rouleau, J. R., Sussex, B., Arnold, J. M., Sestier, F., et al. (1994) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(94)90001-9 · Cited by 282
Task force 3: Recipient guidelines/prioritization
Mudge, G. H., Goldstein, S., Addonizio, L. J., Caplan, A. L., MANCINI, D. M., Levine, T. B., Ritsch, M. E., & Stevenson, L. W. (1993) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(93)90812-f · Cited by 279
Self-citation
New Insights in Cardiac β-Adrenergic Signaling During Heart Failure and Aging
de Lucia, C., Eguchi, A., & Koch, W. J. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00904 · Cited by 291
Additive Beneficial Effects of Beta-Blockers to Angiotensin-Converting Enzyme Inhibitors in the Survival and Ventricular Enlargement (SAVE) Study fn1fn1This study was supported by a University-Industry grant from the Medical Research Council, Ottawa, Ontario, Canada and Bristol Myers Squibb, Montreal, Quebec, Canada.
Vantrimpont, P., Rouleau, J. L., Wun, C.-C., Ciampi, A., Klein, M., Sussex, B., Arnold, J. M. O., Moyé, L., & Pfeffer, M. (1997) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(96)00489-5 · Cited by 274
Stretch-induced arrhythmias in the isolated canine ventricle. Evidence for the importance of mechanoelectrical feedback.
Hansen, D. E., Craig, C. S., & Hondeghem, L. M. (1990) · Circulation · doi:10.1161/01.cir.81.3.1094 · Cited by 274
Augmented Peripheral Chemosensitivity as a Potential Input to Baroreflex Impairment and Autonomic Imbalance in Chronic Heart Failure
Ponikowski, P. P., Chua, T. P., Piepoli, M. F., Ondušová, D., Webb-Peploe, K., Harrington, D., Anker, S. D., Volterrani, M., Colombo, R., MAZZUERO, G., et al. (1997) · Circulation · doi:10.1161/01.cir.96.8.2586 · Cited by 269
Clinical and hemodynamic correlates of sympathetic nerve activity in normal humans and patients with heart failure: Evidence from direct micronenrographic recordings
Ferguson, D. W., Berg, W. J., Sanders, J. S., & Kempf, J. S. (1990) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(90)90544-y · Cited by 269
Myocardial-Directed Overexpression of the Human β1-Adrenergic Receptor in Transgenic Mice
Bisognano, J. D., Weinberger, H. D., Bohlmeyer, T. J., Pende, A., Raynolds, M. V., Sastravaha, A., Roden, R. L., Asano, K., Blaxall, B. C., Wu, S. C., et al. (2000) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2000.1123 · Cited by 270
-Adrenergic Signaling in the Heart: Dual Coupling of the 2-Adrenergic Receptor to Gs and Gi Proteins
Xiao, R. (2001) · Science Signaling · doi:10.1126/stke.2001.104.re15 · Cited by 285
Determinants and importance of stress hyperglycaemia in non-diabetic patients with myocardial infarction.
Oswald, G. A., Smith, C. C. T., Betteridge, D. J., & Yudkin, J. S. (1986) · BMJ · doi:10.1136/bmj.293.6552.917 · Cited by 266
Independent prognostic information provided by sphygmomanometrically determined pulse pressure and mean arterial pressure in patients with left ventricular dysfunction
DOMANSKI, M. J., Mitchell, G. F., Norman, J. E., Exner, D. V., Pitt, B., & Pfeffer, M. A. (1999) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(98)00679-2 · Cited by 262
Beta-adrenoceptors in cardiac disease
Brodde, O. (1993) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(93)90030-h · Cited by 263
Prognosis of congestive heart failure and predictors of mortality
Cohn, J. N., & Rector, T. S. (1988) · The American Journal of Cardiology · doi:10.1016/s0002-9149(88)80081-x · Cited by 264
Self-citation
The sympathetic/parasympathetic imbalance in heart failure with reduced ejection fraction
Floras, J. S., & Ponikowski, P. P. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv087 · Cited by 270
The sympathetic nervous system and blood pressure in humans: implications for hypertension
Fisher, J. P., & Paton, J. F. R. (2011) · Journal of Human Hypertension · doi:10.1038/jhh.2011.66 · Cited by 264
Natriuretic peptides: Physiology, therapeutic potential, and risk stratification in ischemic heart disease
Stein, B. C., & Levin, R. I. (1998) · American Heart Journal · doi:10.1016/s0002-8703(98)70054-7 · Cited by 259
Arrhythmias and mortality in congestive heart failure
KJEKSHUS, J. K. (1990) · The American Journal of Cardiology · doi:10.1016/0002-9149(90)90125-k · Cited by 257
Clinical implications of increased plasma angiotensin II despite ACE inhibitor therapy in patients with congestive heart failure
Roig, E. S. (2000) · European Heart Journal · doi:10.1053/euhj.1999.1740 · Cited by 250
The autonomic nervous system and cardiac arrhythmias: current concepts and emerging therapies
Herring, N., Kalla, M., & Paterson, D. J. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0221-2 · Cited by 262
Clinical, hemodynamic and sympathetic neural correlates of heart rate variability in congestive heart failure
Kienzle, M. G., Ferguson, D. W., Birkett, C. L., Myers, G. A., Berg, W. J., & Mariano, D. J. (1992) · The American Journal of Cardiology · doi:10.1016/0002-9149(92)90502-p · Cited by 249
Cardiac Adrenoceptors: Physiological and Pathophysiological Relevance
Brodde, O., Bruck, H., & Leineweber, K. (2006) · Journal of Pharmacological Sciences · doi:10.1254/jphs.crj06001x · Cited by 253
Cardiac troponin level elevations not related to acute coronary syndromes
Giannitsis, E., & Katus, H. A. (2013) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2013.129 · Cited by 243
The 2009 Carl Ludwig Lecture: pathophysiology of the human sympathetic nervous system in cardiovascular diseases: the transition from mechanisms to medical management
Esler, M. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00832.2009 · Cited by 245
Sympathetic Nervous System Activation in Essential Hypertension, Cardiac Failure and Psychosomatic Heart Disease
Esler, M., & Kaye, D. M. (2000) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-200000004-00001 · Cited by 237
Prognostic value of MIBG imaging in idiopathic dilated cardiomyopathy.
Merlet, P., Benvenuti, C., Moyse, D., Pouillart, F., Dubois‐Randé, J., Duval, A., Loisance, D. Y., Castaigne, A., & Syrota, A. (1999) · PubMed · Cited by 240
Decisions about Resuscitation: Inequities among Patients with Different Diseases but Similar Prognoses
Wachter, R. M., Luce, J. M., Hearst, N., & Lo, B. (1989) · Annals of Internal Medicine · doi:10.7326/0003-4819-111-6-525 · Cited by 240
Prognostic value of plasma endothelin-1 in patients with chronic heart failure
Pousset, F., Isnard, R., Lechat, P. P., Kalotka, H., Carayon, A., Maistre, G., Escolano, S., Thomas, D., & Michel Komajda, N. (1997) · European Heart Journal · doi:10.1093/oxfordjournals.eurheartj.a015228 · Cited by 238
Adrenal GRK2 upregulation mediates sympathetic overdrive in heart failure
Lymperopoulos, A., Rengo, G., Funakoshi, H., Eckhart, A. D., & Koch, W. J. (2007) · Nature Medicine · doi:10.1038/nm1553 · Cited by 236
Neurohormonal activation rapidly decreases after intravenous therapy withdiuretics and vasodilators for class IV heart failure
Johnson, W., Omland, T., Hall, C., Lucas, C., Myking, O. L., Collins, C. M., Pfeffer, M. A., Rouleau, J. L., & Stevenson, L. W. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)01814-4 · Cited by 235
Central Sleep Apnea and Cheyne-Stokes Respiration
Yumino, D., & Bradley, T. D. (2008) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200708-129mg · Cited by 236
Cardiac Iodine-123 Metaiodobenzylguanidine Imaging Predicts Sudden Cardiac Death Independently of Left Ventricular Ejection Fraction in Patients With Chronic Heart Failure and Left Ventricular Systolic Dysfunction
Tamaki, S., Yamada, T., Okuyama, Y., Morita, T., Sanada, S., Tsukamoto, Y., Masuda, M., Okuda, K., Iwasaki, Y., Yasui, T., et al. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.10.025 · Cited by 232
Evidence for reduction of norepinephrine uptake sites in the failing human heart
Böhm, M., Rosée, K. L., Schwinger, R. H., & Erdmann, E. (1995) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(94)00353-r · Cited by 235
Blood Ketone Bodies in Congestive Heart Failure
Lommi, J., Kupari, M. M., Koskinen, P., Näveri, H., Leinonen, H., Pulkki, K. J., & Härkönen, M. (1996) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(96)00214-8 · Cited by 234
Sustained augmentation of parasympathetic tone with angiotensin-converting enzyme inhibition in patients with congestive heart failure
Binkley, P. F., Haas, G. J., Starling, R. C., Nunziata, E., Hatton, P. A., Leier, C. V., & Cody, R. J. (1993) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(93)90098-l · Cited by 233
Inotropic therapy for heart failure: An evidence-based approach
Felker, G. M., & O’Connor, C. M. (2001) · American Heart Journal · doi:10.1067/mhj.2001.117606 · Cited by 232
Treatments targeting inotropy
Maack, C., Eschenhagen, T., Hamdani, N., Heinzel, F. R., Lyon, A. R., Manstein, D. J., Metzger, J. M., Papp, Z., Tocchetti, C. G., Yılmaz, M. B., et al. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy600 · Cited by 237
Adrenergic Nervous System in Heart Failure
Esler, M., Kaye, D. M., Lambert, G. W., Esler, D., & Jennings, G. (1997) · The American Journal of Cardiology · doi:10.1016/s0002-9149(97)00844-8 · Cited by 227
Plasma brain natriuretic peptide level as a biochemical marker of morbidity and mortality in patients with asymptomatic or minimally symptomatic left ventricular dysfunction. Comparison with plasma angiotensin II and endothelin-1
Tsutamoto, T. (1999) · European Heart Journal · doi:10.1053/euhj.1999.1746 · Cited by 230
Impaired acetylcholine-mediated vasodilation in patients with congestive heart failure. Role of endothelium-derived vasodilating and vasoconstricting factors.
Katz, S. D., Schwarz, M., Yuen, J., & LeJemtel, T. H. (1993) · Circulation · doi:10.1161/01.cir.88.1.55 · Cited by 227
Effect of cardiac sympathetic nervous activity on mode of death in congestive heart failure
Brunner-La Rocca, H. (2001) · European Heart Journal · doi:10.1053/euhj.2000.2407 · Cited by 224
Sympathetic Neural Activity in Hypertension and Related Diseases
Grassi, G. M. (2010) · American Journal of Hypertension · doi:10.1038/ajh.2010.154 · Cited by 225
Cardiac sympathetic nervous activity in congestive heart failure. Evidence for increased neuronal norepinephrine release and preserved neuronal uptake.
Meredith, I. T., Eisenhofer, G., Lambert, G. W., Dewar, E., Jennings, G., & Esler, M. (1993) · Circulation · doi:10.1161/01.cir.88.1.136 · Cited by 226
Relation of neurohumoral activation to clinical variables and degree of ventricular dysfunction: A report from the registry of studies of left ventricular dysfunction
Benedict, C. R., Johnstone, D. E., Weiner, D. H., Bourassa, M. G., Bittner, V., Kay, R., Kirlin, P. C., Greenberg, B., Kohn, R. M., Nicklas, J. M., et al. (1994) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(94)90385-9 · Cited by 222
Predicting death due to progressive heart failure in patients with mild-to-moderate chronic heart failure
Kearney, M. T., Fox, K. A. A., Lee, A. J., Prescott, R. J., Shah, A. M., Batin, P. D., Baig, W., Lindsay, S. F., Callahan, T. S., Shell, W. E., et al. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)02490-7 · Cited by 220
Emergence of Blood Urea Nitrogen as a Biomarker of Neurohormonal Activation in Heart Failure
Kazory, A. (2010) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2010.04.024 · Cited by 218
Risk stratification in chronic heart failure
Cowburn, P. (1998) · European Heart Journal · doi:10.1053/euhj.1997.0820 · Cited by 219
Peak exercise cardiac power output; a direct indicator of cardiac function strongly predictive of prognosis in chronic heart failure
Williams, S. (2001) · European Heart Journal · doi:10.1053/euhj.2000.2547 · Cited by 215
Cardiac remodeling and failure
Fedak, P. W. M., Verma, S., Weisel, R. D., & Li, R. (2005) · Cardiovascular Pathology · doi:10.1016/j.carpath.2004.12.002 · Cited by 219
Autonomic pathophysiology in heart failure patients. Sympathetic-cholinergic interrelations.
Porter, T. R., Eckberg, D. L., Fritsch, J. M., Rea, R. F., Beightol, L. A., Schmedtje, J. F., & Mohanty, P. K. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114580 · Cited by 213
The Ross Classification for Heart Failure in Children After 25 Years: A Review and an Age-Stratified Revision
Ross, R. D. (2012) · Pediatric Cardiology · doi:10.1007/s00246-012-0306-8 · Cited by 213
Comorbidity of atrial fibrillation and heart failure
Ling, L., Kistler, P. M., Kalman, J. M., SCHILLING, R. J., & Hunter, R. J. (2015) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2015.191 · Cited by 217
Depression and Risk of Heart Failure Among Older Persons With Isolated Systolic Hypertension
Abramson, J. L., Berger, A. K., Krumholz, H. M., & Vaccarino, V. (2001) · Archives of Internal Medicine · doi:10.1001/archinte.161.14.1725 · Cited by 211
Neurohumoral Prediction of Benefit From Carvedilol in Ischemic Left Ventricular Dysfunction
Richards, M., Doughty, R. N., Nicholls, M. G., MacMahon, S. W., Ikram, H., Sharpe, N., Espiner, E. A., Frampton, C. M., & Yandle, T. G. (1999) · Circulation · doi:10.1161/01.cir.99.6.786 · Cited by 211
Effects of heart failure on baroreflex control of sympathetic neural activity
Ferguson, D. W., Berg, W. J., ROACH, P. J., Oren, R. M., & Mark, A. L. (1992) · The American Journal of Cardiology · doi:10.1016/0002-9149(92)90998-e · Cited by 210
Effects of Carvedilol, a Vasodilator–β-Blocker, in Patients With Congestive Heart Failure Due to Ischemic Heart Disease
(1995) · Circulation · doi:10.1161/01.cir.92.2.212 · Cited by 217
Very Low Frequency Power of Heart Rate Variability is a Powerful Predictor of Clinical Prognosis in Patients With Congestive Heart Failure
Hadase, M., Azuma, A., Zen, K., Asada, S., Kawasaki, T., Kamitani, T., Kawasaki, S., Sugihara, H., & Matsubara, H. (2004) · Circulation Journal · doi:10.1253/circj.68.343 · Cited by 212
A Pooled Analysis of Multicenter Cohort Studies of 123I-mIBG Imaging of Sympathetic Innervation for Assessment of Long-Term Prognosis in Heart Failure
Nakata, T., Nakajima, K., Yamashina, S., Yamada, T., Momose, M., Kasama, S., Matsui, T., Matsuo, S., Travin, M. I., & Jacobson, A. F. (2013) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2013.02.007 · Cited by 206
Inhibition of Na + -H + Exchange Prevents Hypertrophy, Fibrosis, and Heart Failure in β 1 -Adrenergic Receptor Transgenic Mice
Engelhardt, S. H., Hein, L., Keller, U., Klämbt, K., & Lohse, M. J. (2002) · Circulation Research · doi:10.1161/01.res.0000014966.97486.c0 · Cited by 206
Long-term efficacy of physiologic dual-chamber pacing in the treatment of end-stage idiopathic dilated cardiomyopathy
Hochleitner, M., Hörtnagl, H., Hörtnagl, H., Fridrich, L., & Gschnitzer, F. (1992) · The American Journal of Cardiology · doi:10.1016/0002-9149(92)90769-u · Cited by 206

Authors: Cohn, J. N., Levine, T. B., Olivari, M. T., Garberg, V., Lura, D., Francis, G. S., Simon, A. B., & Rector, T.
Affiliations: University of Minnesota (US)
ORCID: Cohn, Jay N.
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 1984-09-27
Volume: 311
Issue: 13
Pages: 819-823
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejm198409273111303
OpenAlex: W2338638760
Cited by: 3,125
References: 23
Citations by year: 2026: 22 · 2025: 30 · 2024: 22 · 2023: 44 · 2022: 50 · 2021: 49 · 2020: 54 · 2019: 58 · 2018: 42 · 2017: 57 · 2016: 75 · 2015: 73 · 2014: 101 · 2013: 87 · 2012: 88
FWCI: 34.36
Type: journal article
Language: en
Open access: closed
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
Health Sciences › Medicine › Nephrology › Electrolyte and hormonal disorders
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
Keywords: plasma norepinephrine, congestive heart failure, prognosis, mortality risk, plasma renin activity, hemodynamics, sudden death, progressive heart failure, prognostic factors, heart rate, stroke work index, serum sodium
MeSH terms: Age Factors, Blood Pressure, Female, Follow-Up Studies, Heart Failure, Heart Rate, Hemodynamics, Humans, Male, Middle Aged, Norepinephrine, Prognosis, Pulmonary Wedge Pressure, Renin

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Plasma Norepinephrine as a Guide to Prognosis in Patients with Chronic Congestive Heart Failure

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks