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Cited by 3,125Heart Failure Treatment and ManagementElectrolyte and hormonal disordersCardiac Fibrosis and Remodeling

The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.

Plasma Norepinephrine as a Guide to Prognosis in Patients with Chronic Congestive Heart Failure

Cohn, Jay N., Levine, T. Barry, Olivari, Maria Teresa, Garberg, Victoria, Lura, Dennis, Francis, Gary S., Simon, Ada B., Rector, Thomas·1984·New England Journal of Medicine
DOI 10.1056/nejm198409273111303
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Abstract

Hemodynamics, plasma norepinephrine, and plasma renin activity were measured at supine rest in 106 patients (83 men and 23 women) with moderate to severe congestive heart failure. During follow-up lasting 1 to 62 months, 60 patients died (57 per cent); 47 per cent of the deaths were sudden, and 45 per cent were related to progressive heart failure. Statistically unrelated to the risk of mortality were cause of disease (60 patients had coronary disease, and 46 had cardiomyopathy), age (mean, 54.8 years), cardiac index (mean, 2.11 liters per minute per square meter of body-surface area), pulmonary wedge pressure (mean, 24.5 mm Hg), and mean arterial pressure (mean, 83.2 mm Hg). A multivariate analysis of the five significant univariate prognosticators--heart rate (mean, 84.4 beats per minute), plasma renin activity (mean, 15.4 ng per milliliter per hour), plasma norepinephrine (mean, 700 pg per milliliter), serum sodium (mean, 135.7 mmol per liter), and stroke-work index (mean, 21.0 g-meters per square meter)--found only plasma norepinephrine to be independently (P = 0.002) related to the subsequent risk of mortality. Norepinephrine was also higher in patients who died from progressive heart failure than in those who died suddenly. These data suggest that a single resting venous blood sample showing the plasma norepinephrine concentration provides a better guide to prognosis than other commonly measured indexes of cardiac performance.

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Crossref · 10.1056/nejm198409273111303

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Research works printed but not linked: 2

  1. Hopkins A. Survival analysis with covariates — Cox models. In: BMDP statistical software. Berkeley, Calif.: University of California Press, 1983: 576–94.
  2. 10.2307/2281868 · DOI · Paper page

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Metadata

Authors
Cohn, J. N., Levine, T. B., Olivari, M. T., Garberg, V., Lura, D., Francis, G. S., Simon, A. B., & Rector, T.
Affiliations
University of Minnesota (US)
ORCID
Cohn, Jay N.
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
1984-09-27
Volume
311
Issue
13
Pages
819-823
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejm198409273111303
OpenAlex
W2338638760
Cited by
3,125
References
23
Citations by year
2026: 22 · 2025: 30 · 2024: 22 · 2023: 44 · 2022: 50 · 2021: 49 · 2020: 54 · 2019: 58 · 2018: 42 · 2017: 57 · 2016: 75 · 2015: 73 · 2014: 101 · 2013: 87 · 2012: 88
FWCI
34.36
Type
journal article
Language
en
Open access
closed
Locations
  • New England Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
  • Health Sciences › Medicine › Nephrology › Electrolyte and hormonal disorders
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
Keywords
plasma norepinephrine, congestive heart failure, prognosis, mortality risk, plasma renin activity, hemodynamics, sudden death, progressive heart failure, prognostic factors, heart rate, stroke work index, serum sodium
MeSH terms
Age Factors, Blood Pressure, Female, Follow-Up Studies, Heart Failure, Heart Rate, Hemodynamics, Humans, Male, Middle Aged, Norepinephrine, Prognosis, Pulmonary Wedge Pressure, Renin

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