The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Clonal Rearrangements of T-Cell Receptor Genes in Mycosis Fungoides and Dermatopathic Lymphadenopathy
Abstract
Histologic diagnosis of mycosis fungoides may be difficult, especially in lymph nodes that show changes frequently associated with chronic skin disease. As an alternative approach to diagnosis, we have analyzed the configuration of DNA for the beta T-cell receptor genes in biopsy tissues from 14 patients with mycosis fungoides. Clonal rearrangements of these genes were found in each specimen tht contained histologically unambiguous mycosis fungoides. Clonal rearrangements were also found in seven of nine lymph nodes removed from patients with mycosis fungoides and considered histologically to contain only benign lymphadenopathy. Matching rearrangements of beta T-cell receptor genes were detected in benign lymph nodes and histologically involved tissues when paired specimens were available from the same cases. Our findings provide molecular evidence for the clonal T-cell origin of mycosis fungoides and indicate the high incidence of extracutaneous disease in patients with palpable lymphadenopathy. In addition, this study demonstrates that the detection of rearranged T-cell receptor genes can be a sensitive and practical method for the diagnosis and characterization of T-cell neoplasms.
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Cites
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Isolation of cDNA clones encoding T cell-specific membrane-associated proteins
Hedrick, S. M., Cohen, D. I., Nielsen, E. A., & Davis, M. M. (1984) · Nature · doi:10.1038/308149a0 · Cited by 1,244
Sequence relationships between putative T-cell receptor polypeptides and immunoglobulins
Hedrick, S. M., Nielsen, E. A., Kavaler, J., Cohen, D. I., & Davis, M. M. (1984) · Nature · doi:10.1038/308153a0 · Cited by 710
Immunoglobulin-Gene Rearrangements as Unique Clonal Markers in Human Lymphoid Neoplasms
Arnold, A., Cossman, J., Bakhshi, A., Jaffe, E. S., Waldmann, T. A., & Korsmeyer, S. J. (1983) · New England Journal of Medicine · doi:10.1056/nejm198312293092601 · Cited by 600
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Self-citation
Cited by
Wood, G. S., Tung, R. M., Heaffner, A. C., Crooks, C. F., Liao, S., Orozco, R., Veelken, H., Kadin, M. E., Koh, H., Heald, P., et al. (1994) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12389114 · Cited by 349
Self-citationKaltoft, K., Bisballe, S., Dyrberg, T., Boel, E., Rasmussen, P. B., & Thestrup-Pedersen, K. (1992) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/bf02631086 · Cited by 128
Metadata
- Authors
- Weiss, L. M., Hu, E., Wood, G. S., Moulds, C., Cleary, M. L., Warnke, R., & Sklar, J.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1985-08-29
- Volume
- 313
- Issue
- 9
- Pages
- 539-544
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2338997062
- Cited by
- 339
- References
- 13
- FWCI
- 54.15
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Clonal Rearrangements of T-Cell Receptor Genes in Mycosis Fungoides and Dermatopathic Lymphadenopathy. https://app.cochat.ai/papers/10.1056/nejm198508293130903
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- Weiss, L. M., Hu, E., Wood, G. S., Moulds, C., Cleary, M. L., Warnke, R., & Sklar, J. (1985). Clonal Rearrangements of T-Cell Receptor Genes in Mycosis Fungoides and Dermatopathic Lymphadenopathy. New England Journal of Medicine. https://doi.org/10.1056/nejm198508293130903
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
