The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Immunoglobulin-Gene Rearrangements as Unique Clonal Markers in Human Lymphoid Neoplasms
Abstract
Immunoglobulin genes in their germ-line form are separated DNA subsegments that must be joined by means of recombinations during B-cell development. Individual immunoglobulin-gene rearrangements are specific for a given B cell and its progeny. We show that the detection of such gene rearrangements by Southern hybridization provides a sensitive marker for both clonality and B-cell lineage within lymphoid tissues lacking expression of definitive surface phenotypes. We have used these genetic markers in three ways: to establish a diagnosis of lymphoma in a neoplastic disorder of uncertain cell type, to show that some lymphomas that were previously classified as being of T-cell type in fact contain monoclonal B cells, and to detect clonal B-cell populations within lymphomatous tissues of uncertain immunotype and within an atypical lymphofollicular hyperplasia having no other clonal surface markers. These sensitive and unique indicators of clonality located directly at the DNA level are capable of providing insights into the cellular origin, early detection, and natural history of neoplasia.
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Citations
Cites
Somatic generation of antibody diversity
Tonegawa, S. (1983) · Nature · doi:10.1038/302575a0 · Cited by 4,005
Somatic generation of antibody diversity.
Matthyssens, G., Hozumi, N., & Tonegawa, S. (1976) · PubMed · Cited by 3,244
Hsu, S.-M., Raine, L., & Fanger, H. (1981) · American Journal of Clinical Pathology · doi:10.1093/ajcp/75.5.734 · Cited by 1,644
Reinherz, E. L., Kung, P. C., Goldstein, G., Levey, R. H., & Schlossman, S. F. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.3.1588 · Cited by 1,630
Characterization of a human B lymphocyte-specific antigen.
Stashenko, P., Nadler, L. M., Hardy, R., & Schlossman, S. F. (1980) · The Journal of Immunology · doi:10.4049/jimmunol.125.4.1678 · Cited by 1,076
Treatment of B-Cell Lymphoma with Monoclonal Anti-Idiotype Antibody
Miller, R. A., Maloney, D. G., Warnke, R., & Levy, R. (1982) · New England Journal of Medicine · doi:10.1056/nejm198203043060906 · Cited by 985
Early, P., Huang, H., Davis, M., Calame, K., & Hood, L. (1980) · Cell · doi:10.1016/0092-8674(80)90089-6 · Cited by 865
A complete immunoglobulin gene is created by somatic recombination
Brack, C., Hirama, M., Lenhard-Schuller, R., & Tonegawa, S. (1978) · Cell · doi:10.1016/0092-8674(78)90078-8 · Cited by 610
Reinherz, E. L., Kung, P. C., Pesando, J. M., Ritz, J., Goldstein, G., & Schlossman, S. F. (1979) · The Journal of experimental medicine · doi:10.1084/jem.150.6.1472 · Cited by 574
Developmental hierarchy of immunoglobulin gene rearrangements in human leukemic pre-B-cells.
Korsmeyer, S. J., Hieter, P. A., Ravetch, J. V., Poplack, D. G., Waldmann, T. A., & Leder, P. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.11.7096 · Cited by 548
Self-citation
Cited by
The structure of the termini of the Epstein-Barr virus as a marker of clonal cellular proliferation
Raab-Traub, N., & Flynn, K. (1986) · Cell · doi:10.1016/0092-8674(86)90803-2 · Cited by 912
Clonal Origin of Bladder Cancer
Sidransky, D., Frost, P., Von Eschenbach, A., Oyasu, R., Preisinger, A. C., & Vogelstein, B. (1992) · New England Journal of Medicine · doi:10.1056/nejm199203123261104 · Cited by 532
Weiss, L. M., Hu, E., Wood, G. S., Moulds, C., Cleary, M. L., Warnke, R., & Sklar, J. (1985) · New England Journal of Medicine · doi:10.1056/nejm198508293130903 · Cited by 339
Monoclonality and Abnormal Parathyroid Hormone Genes in Parathyroid Adenomas
Arnold, A., Staunton, C. E., Kim, H. G., Gaz, R. D., & Kronenberg, H. M. (1988) · New England Journal of Medicine · doi:10.1056/nejm198803173181102 · Cited by 294
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Metadata
- Authors
- Arnold, A., Cossman, J., Bakhshi, A., Jaffe, E. S., Waldmann, T. A., & Korsmeyer, S. J.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1983-12-29
- Volume
- 309
- Issue
- 26
- Pages
- 1593-1599
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2335942423
- Cited by
- 600
- References
- 18
- FWCI
- 35.28
- Type
- journal article
- Language
- en
- Open access
- closed
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- Arnold, A., Cossman, J., Bakhshi, A., Jaffe, E. S., Waldmann, T. A., & Korsmeyer, S. J. (1983). Immunoglobulin-Gene Rearrangements as Unique Clonal Markers in Human Lymphoid Neoplasms. New England Journal of Medicine. https://doi.org/10.1056/nejm198312293092601
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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