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Cited by 601

The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.

Acute Cardiac Events Temporally Related to Cocaine Abuse

Isner, Jeffrey M., Estes, N.A. Mark, Thompson, Paul D., Costanzo-Nordin, Maria Rosa, Subramanian, Ramiah, Miller, Gary, Katsas, George, Sweeney, Kristin, Sturner, William Q.·1986·New England Journal of Medicine

Abstract

The increasingly widespread use of cocaine in the United States has been accompanied and perhaps exacerbated by the misconception that the drug is not associated with serious medical complications. In particular, the potential for cocaine to precipitate life-threatening cardiac events needs to be reemphasized. We report the clinical and pathological findings in seven people in whom nonintravenous "recreational" use of cocaine was temporally related to acute myocardial infarction, ventricular tachycardia and fibrillation, myocarditis, sudden death, or a combination of these events. We also review data on 19 previously reported cases of cocaine-related cardiovascular disorders. Analysis of all 26 patients indicated the following findings: the cardiac consequences of cocaine abuse are not unique to parenteral use of the drug, since nearly all the patients took the drug intranasally; underlying heart disease is not a prerequisite for cocaine-related cardiac disorders; seizure activity, a well-documented noncardiac complication of cocaine abuse, is neither a prerequisite for, nor an accompanying feature of, cardiac toxicity of cocaine; and the cardiac consequences of cocaine are not limited to massive doses of the drug. Although the pathogenesis of cardiac toxicity of cocaine remains incompletely defined, available circumstantial evidence suggests that cocaine has medical consequences that are equal in importance to its well-documented psychosocial consequences.

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Crossref · 10.1056/nejm198612043152302

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Metadata

Authors
Isner, J. M., Estes, N. A. M., Thompson, P. D., Costanzo-Nordin, M. R., Subramanian, R., Miller, G., Katsas, G., Sweeney, K., & Sturner, W. Q.
Venue
New England Journal of Medicine
Published
1986-12-04
Volume
315
Issue
23
Pages
1438-1443
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
OpenAlex
W2316853010
Cited by
601
References
22
FWCI
30.22
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Acute Cardiac Events Temporally Related to Cocaine Abuse. https://app.cochat.ai/papers/10.1056/nejm198612043152302
The paper
Isner, J. M., Estes, N. A. M., Thompson, P. D., Costanzo-Nordin, M. R., Subramanian, R., Miller, G., Katsas, G., Sweeney, K., & Sturner, W. Q. (1986). Acute Cardiac Events Temporally Related to Cocaine Abuse. New England Journal of Medicine. https://doi.org/10.1056/nejm198612043152302

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.