The DOI matches its Crossref record; 255 of the 255 references it cites were found in a registry or an index.
Host Responses in Tissue Repair and Fibrosis
Open accessAbstract
Myofibroblasts accumulate in the spaces between organ structures and produce extracellular matrix (ECM) proteins, including collagen I. They are the primary “effector” cells in tissue remodeling and fibrosis. Previously, leukocyte progenitors termed fibrocytes and myofibroblasts generated from epithelial cells through epithelial-to-mesenchymal transition (EMT) were considered the primary sources of ECM-producing myofibroblasts in injured tissues. However, genetic fate mapping experiments suggest that mesenchyme-derived cells, known as resident fibroblasts, and pericytes are the primary precursors of scar-forming myofibroblasts, whereas epithelial cells, endothelial cells, and myeloid leukocytes contribute to fibrogenesis predominantly by producing key fibrogenic cytokines and by promoting cell-to-cell communication. Numerous cytokines derived from T cells, macrophages, and other myeloid cell populations are important drivers of myofibroblast differentiation. Monocyte-derived cell populations are key regulators of the fibrotic process: They act as a brake on the processes driving fibrogenesis, and they dismantle and degrade established fibrosis. We discuss the origins, modes of activation, and fate of myofibroblasts in various important fibrotic diseases and describe how manipulation of macrophage activation could help ameliorate fibrosis.
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1 retracted
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The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology
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Cellular and molecular mechanisms of fibrosis
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Self-citationCellular and Molecular Mechanisms of Pain
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Cited by
Macrophages in Tissue Repair, Regeneration, and Fibrosis
Wynn, T. A., & Vannella, K. M. (2016) · Immunity · doi:10.1016/j.immuni.2016.02.015 · Cited by 4,481
Self-citationRemodelling the extracellular matrix in development and disease
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TGF-β: the master regulator of fibrosis
Meng, X.-M., Nikolic-Paterson, D. J., & Lan, H. Y. (2016) · Nature Reviews Nephrology · doi:10.1038/nrneph.2016.48 · Cited by 3,528
Murray, P. J. (2017) · Annual Review of Physiology · doi:10.1146/annurev-physiol-022516-034339 · Cited by 2,981
Longitudinal analyses reveal immunological misfiring in severe COVID-19
Lucas, C., Wong, P., Klein, J., Castro, T. B. R., Silva, J., Sundaram, M., Ellingson, M. K., Mao, T., Oh, J. E., Israelow, B., et al. (2020) · Nature · doi:10.1038/s41586-020-2588-y · Cited by 2,074
Metadata
- Authors
- Duffield, J. S., Lupher, M., Thannickal, V. J., & Wynn, T. A.
- Venue
- Annual Review of Pathology: Mechanisms of Disease
- Publisher
- Annual Reviews
- Published
- 2013-01-24
- Volume
- 8
- Issue
- 1
- Pages
- 241-276
- ISSN
- 1553-4006 (ISSN-L)
- 1553-4014
- OpenAlex
- W2099486691
- Cited by
- 624
- References
- 255
- FWCI
- 7.27
- Type
- journal article
- Language
- en
- Open access
- green
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- Duffield, J. S., Lupher, M., Thannickal, V. J., & Wynn, T. A. (2013). Host Responses in Tissue Repair and Fibrosis. Annual Review of Pathology: Mechanisms of Disease. https://doi.org/10.1146/annurev-pathol-020712-163930
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
