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Prognostic Implications of Echocardiographically Determined Left Ventricular Mass in the Framingham Heart Study

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Levy, Daniel, Garrison, Robert J., Savage, Daniel D., Kannel, William B., Castelli, William P.·1990·New England Journal of Medicine

DOI 10.1056/nejm199005313222203

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Abstract

A pattern of left ventricular hypertrophy evident on the electrocardiogram is a harbinger of morbidity and mortality from cardiovascular disease. Echocardiography permits the noninvasive determination of left ventricular mass and the examination of its role as a precursor of morbidity and mortality. We examined the relation of left ventricular mass to the incidence of cardiovascular disease, mortality from cardiovascular disease, and mortality from all causes in 3220 subjects enrolled in the Framingham Heart Study who were 40 years of age or older and free of clinically apparent cardiovascular disease, in whom left ventricular mass was determined echocardiographically. During a four-year follow-up period, there were 208 incident cardiovascular events, 37 deaths from cardiovascular disease, and 124 deaths from all causes. Left ventricular mass, determined echocardiographically, was associated with all outcome events. This relation persisted after we adjusted for age, diastolic blood pressure, pulse pressure, treatment for hypertension, cigarette smoking, diabetes, obesity, the ratio of total cholesterol to high-density lipoprotein cholesterol, and electrocardiographic evidence of left ventricular hypertrophy. In men, the risk factor-adjusted relative risk of cardiovascular disease was 1.49 for each increment of 50 g per meter in left ventricular mass corrected for the subject's height (95 percent confidence interval, 1.20 to 1.85); in women, it was 1.57 (95 percent confidence interval, 1.20 to 2.04). Left ventricular mass (corrected for height) was also associated with the incidence of death from cardiovascular disease (relative risk, 1.73 [95 percent confidence interval, 1.19 to 2.52] in men and 2.12 [95 percent confidence interval, 1.28 to 3.49] in women). Left ventricular mass (corrected for height) was associated with death from all causes (relative risk, 1.49 [95 percent confidence interval, 1.14 to 1.94] in men and 2.01 [95 percent confidence interval, 1.44 to 2.81] in women). We conclude that the estimation of left ventricular mass by echocardiography offers prognostic information beyond that provided by the evaluation of traditional cardiovascular risk factors. An increase in left ventricular mass predicts a higher incidence of clinical events, including death, attributable to cardiovascular disease.

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Regression Models and Life-Tables
Cox, D. R. (1972) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1972.tb00899.x · Cited by 39,793
Echocardiographic assessment of left ventricular hypertrophy: Comparison to necropsy findings
Devereux, R. B., Alonso, D. R., Lutas, E. M., Gottlieb, G. J., Campo, E., Sachs, I., & Reichek, N. (1986) · The American Journal of Cardiology · doi:10.1016/0002-9149(86)90771-x · Cited by 6,226
Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method.
Devereux, R. B., & Reichek, N. (1977) · Circulation · doi:10.1161/01.cir.55.4.613 · Cited by 4,499
Epidemiological approaches to heart disease: the Framingham study
Dawber, T. R., Meadors, G. F., & Moore, F. E. (1951) · American Journal of Public Health and the Nations Health · doi:10.2105/ajph.41.3.279 · Cited by 2,148
Value of Echocardiographic Measurement of Left Ventricular Mass in Predicting Cardiovascular Morbid Events in Hypertensive Men
Casale, P. N., Devereux, R. B., Milner, M. R., Zullo, G., Harshfield, G. A., Pickering, T. G., & LARAGH, J. H. (1986) · Annals of Internal Medicine · doi:10.7326/0003-4819-105-2-173 · Cited by 1,079
Echocardiographically Detected Left Ventricular Hypertrophy: Prevalence and Risk Factors
Levy, D. A., Anderson, K. M., SAVAGE, D. D., Kannel, W. B., Christiansen, J. C., & Castelli, W. P. (1988) · Annals of Internal Medicine · doi:10.7326/0003-4819-108-1-7 · Cited by 819
Echocardiographic criteria for left ventricular hypertrophy: The Framingham heart study
Levy, D. A., Savage, D. D., Garrison, R. J., Anderson, K. M., Kannel, W. B., & Castelli, W. P. (1987) · The American Journal of Cardiology · doi:10.1016/0002-9149(87)91133-7 · Cited by 798
Left Ventricular Mass and Incidence of Coronary Heart Disease in an Elderly Cohort
Levy, D. A., Garrison, R. J., Savage, D. D., Kannel, W. B., & Castelli, W. P. (1989) · Annals of Internal Medicine · doi:10.7326/0003-4819-110-2-101 · Cited by 700
Electrocardiographic Left Ventricular Hypertrophy and Risk of Coronary Heart Disease
Kannel, W. B., Gordon, T., Castelli, W. P., & MARGOLIS, J. R. (1970) · Annals of Internal Medicine · doi:10.7326/0003-4819-72-6-813 · Cited by 638
Ventricular Arrhythmias in Patients with Hypertensive Left Ventricular Hypertrophy
McLenachan, J. M., Henderson, E., Morris, K. I., & Dargie, H. J. (1987) · New England Journal of Medicine · doi:10.1056/nejm198709243171302 · Cited by 576

Show all 28 references

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Sharp, A. S. P., Tapp, R. J., Thom, S., Francis, D. P., Hughes, A. D., Stanton, A. V., Zambanini, A., O'Brien, E. T., Chaturvedi, N., Lyons, S., et al. (2009) · European Heart Journal · doi:10.1093/eurheartj/ehp498 · Cited by 207
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Devereux, R. B., Palmieri, V., Sharpe, N., Quattro, V. D., Bella, J. N., SIMONE, G. D., Walker, J. F., Hahn, R. T., & Dahlöf, B. (2001) · Circulation · doi:10.1161/hc3601.095927 · Cited by 207
A Novel Method of Expressing Left Ventricular Mass Relative to Body Size in Children
Foster, B. J., Mackie, A. S., Mitsnefes, M. M., Ali, H., Mamber, S., & Colan, S. D. (2008) · Circulation · doi:10.1161/circulationaha.107.741157 · Cited by 206
Cardiac Alpha1-Adrenergic Receptors: Novel Aspects of Expression, Signaling Mechanisms, Physiologic Function, and Clinical Importance
O’Connell, T. D., Jensen, B. C., Baker, A. J., & Simpson, P. C. (2013) · Pharmacological Reviews · doi:10.1124/pr.112.007203 · Cited by 205
Decreased Perivascular Fibrosis but Not Cardiac Hypertrophy in ROCK1 +/− Haploinsufficient Mice
Rikitake, Y., Oyama, N., Wang, C.-Y. C., Noma, K., Satoh, M., Kim, H.-H., & Liao, J. K. (2005) · Circulation · doi:10.1161/circulationaha.105.584623 · Cited by 205
Upward shift of the lower range of coronary flow autoregulation in hypertensive patients with hypertrophy of the left ventricle.
Polese, A., Cesare, N. D., Montorsi, P., Fabbiocchi, F., Guazzi, M., Loaldi, A., & Guazzi, M. (1991) · Circulation · doi:10.1161/01.cir.83.3.845 · Cited by 205
Altered creatine kinase adenosine triphosphate kinetics in failing hypertrophied human myocardium
Smith, C. S., Bottomley, P. A., Schulman, S. P., Gerstenblith, G., & Weiss, R. G. (2006) · Circulation · doi:10.1161/circulationaha.106.613646 · Cited by 204
Central sympathetic overactivity: Maladies and mechanisms
Fisher, J. P., Young, C. N., & Fadel, P. J. (2009) · Autonomic Neuroscience · doi:10.1016/j.autneu.2009.02.003 · Cited by 210
Effect of Single-Drug Therapy on Reduction of Left Atrial Size in Mild to Moderate Hypertension
Gottdiener, J. S., Reda, D. J., Williams, D. W., Materson, B. J., Cushman, W. G., & Anderson, R. J. (1998) · Circulation · doi:10.1161/01.cir.98.2.140 · Cited by 203
Heart Failure Stages Among Older Adults in the Community
Shah, A. M., Claggett, B. L., Loehr, L. R., Chang, P. P., Matsushita, K., Kitzman, D. W., Konety, S., Kucharska‐Newton, A., Sueta, C. A., Mosley, T. H., et al. (2016) · Circulation · doi:10.1161/circulationaha.116.023361 · Cited by 202
Electrocardiographic Left Ventricular Hypertrophy in Renal Transplant Recipients
Rigatto, C., Foley, R. N., Jeffery, J., Negrijn, C., Tribula, C., & Parfrey, P. S. (2003) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000043141.67989.39 · Cited by 202
Impact of HMG CoA reductase inhibition on small GTPases in the heart
Laufs, U. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(01)00540-5 · Cited by 199
Targeted inhibition of calcineurin attenuates cardiac hypertrophy in vivo
Windt, L. J. D., Lim, H. W., Bueno, O. F., Liang, Q., Delling, U., Braz, J. C., Glascock, B. J., Kimball, T. F., del Monte, F., Hajjar, R. J., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.031371998 · Cited by 202
A novel association between residual renal function and left ventricular hypertrophy in peritoneal dialysis patients
Wang, A. Y.-M., Wang, M., Woo, J., Law, M.-C., Chow, K., Li, P. K., Lui, S., & Sanderson, J. E. (2002) · Kidney International · doi:10.1046/j.1523-1755.2002.00471.x · Cited by 201
Left Ventricular Geometry in Children with Mild to Moderate Chronic Renal Insufficiency
Matteucci, M. C., Wühl, E., Picca, S., Mastrostefano, A., Rinelli, G., Romano, C., Rizzoni, G., Mehls, O., SIMONE, G. D., & Schaefer, F. S. (2005) · Journal of the American Society of Nephrology · doi:10.1681/asn.2005030276 · Cited by 202
Relations of Left Ventricular Mass to Demographic and Hemodynamic Variables in American Indians
Devereux, R. B., Roman, M. J., SIMONE, G. D., O’Grady, M. J., Paranicas, M., Yeh, J. L., Fabsitz, R. R., & Howard, B. V. (1997) · Circulation · doi:10.1161/01.cir.96.5.1416 · Cited by 200
Ambulatory blood pressure, left ventricular mass, and conduit artery function late after successful repair of coarctation of the aorta
de Divitiis, M., Pilla, C. B., Kattenhorn, M., Donald, A. E., Zadinello, M., Wallace, S. M. L., Redington, A. N., & Deanfield, J. E. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00480-7 · Cited by 200
PKCα regulates the hypertrophic growth of cardiomyocytes through extracellular signal–regulated kinase1/2 (ERK1/2)
Braz, J. C., Bueno, O. F., Windt, L. J. D., & Molkentin, J. D. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200108062 · Cited by 199
The Aging Heart and Post-Infarction Left Ventricular Remodeling
Shih, H., Lee, B. K. H., Lee, R. J., & Boyle, A. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.08.623 · Cited by 206
RGS4 causes increased mortality and reduced cardiac hypertrophy in response to pressure overload
Rogers, J. H., Tamirisa, P. K., Kovács, A. D., Weinheimer, C. J., COURTOIS, M. R., Blumer, K., Kelly, D. P., & Muslin, A. J. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6713 · Cited by 197
The smoothness index
Parati, G., Omboni, S., Rizzoni, D., Agabiti‐Rosei, E., & Manciaa, G. (1998) · Journal of Hypertension · doi:10.1097/00004872-199816110-00016 · Cited by 196
Influence of the Angiotensin II Antagonist Valsartan on Left Ventricular Hypertrophy in Patients With Essential Hypertension
Thürmann, P., Kenedi, P., Schmidt, A., Harder, S., & Rietbrock, N. H. (1998) · Circulation · doi:10.1161/01.cir.98.19.2037 · Cited by 195
Cardiac remodeling at the population level—risk factors, screening, and outcomes
Gjesdal, O., Bluemke, D. A., & Lima, J. A. C. (2011) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2011.154 · Cited by 194
Activator or inhibitor? GSK-3 as a new drug target
Takahashi‐Yanaga, F. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.04.022 · Cited by 200
Peroxisome Proliferator-Activated Receptor γ Activators Inhibit Cardiac Hypertrophy in Cardiac Myocytes
Yamamoto, K., Ohki, R., Lee, R. T., Ikeda, U., & Shimada, K. (2001) · Circulation · doi:10.1161/hc4001.097186 · Cited by 192
Impact of Valve Prosthesis-Patient Mismatch on Left Ventricular Mass Regression Following Aortic Valve Replacement
Tasca, G., Brunelli, F., Cirillo, M., DallaTomba, M., Mhagna, Z., Troise, G., & Quaini, E. L. (2005) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2004.04.042 · Cited by 193
Arterial Elastance and Wave Reflection Augmentation of Systolic Blood Pressure: Deleterious Effects and Implications for Therapy
Nichols, W. W., & Edwards, D. G. (2001) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/107424840100600102 · Cited by 200
Lifetime risk: childhood obesity and cardiovascular risk
Ayer, J. G., Charakida, M., Deanfield, J. E., & Celermajer, D. S. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv089 · Cited by 191
Impact of Long-Term Burden of Excessive Adiposity and Elevated Blood Pressure From Childhood on Adulthood Left Ventricular Remodeling Patterns
Lai, C.-C., Sun, D., Cen, R., Wang, J., Li, S., Fernandez‐Alonso, C., Chen, W., Srinivasan, S. R., & Berenson, G. S. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.05.072 · Cited by 191
Late systemic hypertension and aortic arch geometry after successful repair of coarctation of the aorta
Ou, P., Bonnet, D., Auriacombe, L., Pedroni, E., Balleux, F., Sidi, D., & Mousseaux, É. (2004) · European Heart Journal · doi:10.1016/j.ehj.2004.07.021 · Cited by 191
Cardiovascular complications in renal failure.
Rostand, S. G., Brunzell, J. D., Cannon, R. O., & Victor, R. G. (1991) · Journal of the American Society of Nephrology · doi:10.1681/asn.v261053 · Cited by 191
Arterial stiffness and central blood pressure, as determined by pulse wave analysis, in rheumatoid arthritis
Klocke, R., Cockcroft, J. R., Taylor, G. J., Hall, I. R., & Blake, D. R. (2003) · Annals of the Rheumatic Diseases · doi:10.1136/ard.62.5.414 · Cited by 190

Authors: Levy, D., Garrison, R. J., Savage, D. D., Kannel, W. B., & Castelli, W. P.
Affiliations: National Heart, Lung, and Blood Institute (US)
National Center for Health Statistics (US)
Boston University (US)
ORCID: Levy, Daniel
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 1990-05-31
Volume: 322
Issue: 22
Pages: 1561-1566
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejm199005313222203
OpenAlex: W2334499091
Cited by: 5,699
References: 28
Citations by year: 2026: 77 · 2025: 76 · 2024: 85 · 2023: 100 · 2022: 117 · 2021: 124 · 2020: 156 · 2019: 142 · 2018: 134 · 2017: 170 · 2016: 189 · 2015: 211 · 2014: 215 · 2013: 199 · 2012: 215
FWCI: 76.54
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Effects of Exercise
Keywords: left ventricular mass, left ventricular hypertrophy, cardiovascular disease incidence, cardiovascular mortality, all-cause mortality, echocardiography, cardiovascular risk factors, hypertension, sex differences, Framingham Heart Study
MeSH terms: Blood Pressure, Echocardiography, Female, Follow-Up Studies, Cardiomegaly, Humans, Lipids, Male, Middle Aged, Prognosis, Risk Factors, Smoking, Multivariate Analysis, Diabetes Complications

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Prognostic Implications of Echocardiographically Determined Left Ventricular Mass in the Framingham Heart Study

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